Entrez gene ID | | 32 |
Official gene symbol | | ACACB |
Full name | | acetyl-CoA carboxylase beta |
Aliases | | ,ACC2,ACCB,HACC275, |
Gene summary | | Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. There is evidence for the presence of two ACC-beta isoforms. [provided by RefSeq] |
Location | | Chromosome: 12 Locus: 12q24.11 |
Gene position | | 109577202 - 109706031 Map Viewer |
Gene orientation | | plus |
Gene size | | 128830 bp |
Gene sequence |
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OMIM ID | | 601557 |
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