Entrez gene ID | | 9459 |
Official gene symbol | | ARHGEF6 |
Full name | | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 |
Aliases | | ,COOL2,Cool-2,KIAA0006,MRX46,PIXA,alpha-PIX,alphaPIX, |
Gene summary | | Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation. [provided by RefSeq] |
Location | | Chromosome: X Locus: Xq26.3 |
Gene position | | 135863503 - 135747709 Map Viewer |
Gene orientation | | minus |
Gene size | | 115795 bp |
Gene sequence |
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OMIM ID | | 300267 |