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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for PRMT5 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA GO:0000387 spliceosomal snRNP assembly IMP GO:0000387 spliceosomal snRNP assembly TAS GO:0006355 regulation of transcription, DNA-dependent IEA GO:0007088 regulation of mitosis TAS GO:0008283 cell proliferation TAS GO:0016070 RNA metabolic process TAS GO:0016568 chromatin modification IEA GO:0018216 peptidyl-arginine methylation IMP GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine IMP GO:0034660 ncRNA metabolic process TAS GO:0035246 peptidyl-arginine N-methylation IDA GO:0043985 histone H4-R3 methylation NAS cellular_component GO:0005634 nucleus IDA GO:0005634 nucleus IEA GO:0005634 nucleus NAS GO:0005737 cytoplasm IDA GO:0005737 cytoplasm IEA GO:0005829 cytosol TAS GO:0043234 protein complex IEA molecular_function GO:0003682 chromatin binding IEA GO:0005515 protein binding IPI GO:0008168 methyltransferase activity IDA GO:0008168 methyltransferase activity IEA GO:0008469 histone-arginine N-methyltransferase activity IEA GO:0016740 transferase activity IEA GO:0035243 protein-arginine omega-N symmetric methyltransferase activity IMP GO:0043021 ribonucleoprotein binding IPI

Protein-protein interaction details for PRMT5 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID JAK2 Two-hybrid physical 10531356 CLNS1A Two-hybrid physical 9556550 FBL Affinity Capture-MS physical 14583623 SUPT5H Affinity Capture-MS physical 12718890 SUPT5H Biochemical Activity physical 12718890 SUPT5H Affinity Capture-Western physical 12718890 SNRPD3 Affinity Capture-MS physical 11713266 SNRPD3 Reconstituted Complex physical 11713266 SNRPD1 Reconstituted Complex physical 11713266 CLNS1A Affinity Capture-Western physical 11713266 CLNS1A Affinity Capture-MS physical 9556550 CLNS1A Reconstituted Complex physical 9556550 PRMT5 Affinity Capture-Western physical 11152681 MBP Biochemical Activity physical 11152681 JAK1 Reconstituted Complex physical 10531356 JAK2 Reconstituted Complex physical 10531356 JAK3 Reconstituted Complex physical 10531356 TYK2 Reconstituted Complex physical 10531356 PRMT5 Affinity Capture-Western physical 10531356 CLNS1A Affinity Capture-MS physical 11756452 WDR77 Affinity Capture-MS physical 11756452 CLNS1A Affinity Capture-MS physical 11756452 CLNS1A Affinity Capture-Western physical 11756452 WDR77 Affinity Capture-Western physical 11756452 WDR77 Reconstituted Complex physical 11756452 CLNS1A Reconstituted Complex physical 11756452 CLNS1A Reconstituted Complex physical 11756452 WDR77 Reconstituted Complex physical 11756452 PHYHIP Two-hybrid physical 16169070 OLA1 Two-hybrid physical 16169070 PRDM1 Affinity Capture-Western physical 16699504 PRDM1 Affinity Capture-Western physical 18992153 KHDRBS2 Affinity Capture-MS physical 17643375 MYOD1 Affinity Capture-MS physical 20195544 NFE4 Affinity Capture-Western physical 19234465 DNMT3A Reconstituted Complex physical 19234465 MEF2D Reconstituted Complex physical 19188441 MYOD1 Reconstituted Complex physical 19188441 MYOG Reconstituted Complex physical 19188441 ZNF224 Affinity Capture-Western physical 19741270 ZNF224 Affinity Capture-Western physical 19741270 ZNF224 Reconstituted Complex physical 19741270 SKI Affinity Capture-Western physical 19032343 CLNS1A Reconstituted Complex physical 19520849 MBD2 Affinity Capture-Western physical 16980624 MYSM1 Affinity Capture-MS physical 17707232 MBD2 Affinity Capture-Western physical 16428440 SMARCA4 Affinity Capture-MS physical 14559996 SMARCA2 Affinity Capture-MS physical 14559996 SMARCA2 Affinity Capture-Western physical 14559996 SMARCA4 Affinity Capture-Western physical 14559996 SMARCA4 Affinity Capture-Western physical 14559996 SMARCA2 Affinity Capture-Western physical 14559996 SIN3A Affinity Capture-Western physical 14559996 SMARCA4 Reconstituted Complex physical 14559996 SMARCA2 Reconstituted Complex physical 14559996 SIN3A Reconstituted Complex physical 14559996 SMARCE1 Reconstituted Complex physical 14559996 SMARCB1 Reconstituted Complex physical 14559996 SMARCA4 Reconstituted Complex physical 14559996 SMARCA2 Reconstituted Complex physical 14559996 SIN3A Reconstituted Complex physical 14559996 SMARCB1 Reconstituted Complex physical 14559996 SMARCC1 Reconstituted Complex physical 14559996 HIST1H3A Biochemical Activity physical 14559996 HIST1H4A Biochemical Activity physical 14559996 LSM11 Affinity Capture-Western physical 16087681 CTDP1 Affinity Capture-Western physical 15670829 CTDP1 Affinity Capture-Western physical 15670829 HIST1H4A Biochemical Activity physical 15670829 HIST2H2AC Biochemical Activity physical 15670829 HIST1H3A Biochemical Activity physical 15670829 JUB Affinity Capture-Western physical 18347060 JUB Affinity Capture-Western physical 18347060 HIST1H3A Biochemical Activity physical 15485929 HIST1H4A Biochemical Activity physical 15485929 CTNNBL1 Affinity Capture-MS physical 21385873 NCL Affinity Capture-Western physical 17974993 PAXIP1 Affinity Capture-MS physical 17925232 HSP90AA1 Affinity Capture-Western physical 17409432 JAK2 Affinity Capture-Western physical 21316606 JAK2 Affinity Capture-Western physical 21316606 JAK2 Biochemical Activity physical 21316606 WDR77 Affinity Capture-Western physical 21316606 WDR77 Affinity Capture-Western physical 20951943 CCND1 Affinity Capture-Western physical 20951943 CDK4 Affinity Capture-Western physical 20951943 SMARCA4 Affinity Capture-Western physical 20951943 WDR77 Affinity Capture-Western physical 20951943 TERF1 Affinity Capture-MS physical 20811636 TERF2 Affinity Capture-MS physical 20811636 DIO3 Reconstituted Complex physical 17709427 SNRPB Reconstituted Complex physical 17709427 EIF2C3 Affinity Capture-MS physical 19167051 EIF2C4 Affinity Capture-MS physical 19167051 ARID1B Affinity Capture-MS physical 21118156 HDAC5 Affinity Capture-MS physical 21081666 UBC Affinity Capture-MS physical 18781797 UBC Affinity Capture-MS physical 21987572