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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for CYLD (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0002218 activation of innate immune response TAS GO:0006412 translation IEA GO:0006511 ubiquitin-dependent protein catabolic process IEA GO:0006917 induction of apoptosis IDA GO:0007049 cell cycle IEA GO:0007346 regulation of mitotic cell cycle IMP GO:0016055 Wnt receptor signaling pathway IEA GO:0032088 negative regulation of NF-kappaB transcription factor activity IDA GO:0032480 negative regulation of type I interferon production TAS GO:0042347 negative regulation of NF-kappaB import into nucleus IDA GO:0045087 innate immune response TAS GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway TAS GO:0070507 regulation of microtubule cytoskeleton organization IMP GO:0070536 protein K63-linked deubiquitination IDA GO:0090090 negative regulation of canonical Wnt receptor signaling pathway IMP cellular_component GO:0005622 intracellular IEA GO:0005737 cytoplasm IEA GO:0005829 cytosol IDA GO:0005829 cytosol TAS GO:0005840 ribosome IEA GO:0005856 cytoskeleton IEA GO:0005881 cytoplasmic microtubule IDA GO:0005886 plasma membrane IEA GO:0030496 midbody IDA GO:0031234 extrinsic to internal side of plasma membrane IDA GO:0048471 perinuclear region of cytoplasm IEA molecular_function GO:0003735 structural constituent of ribosome IEA GO:0004221 ubiquitin thiolesterase activity IEA GO:0004843 ubiquitin-specific protease activity IDA GO:0005515 protein binding IPI GO:0008233 peptidase activity IEA GO:0008234 cysteine-type peptidase activity IEA GO:0008270 zinc ion binding IDA GO:0019901 protein kinase binding IPI GO:0046872 metal ion binding IEA GO:0070064 proline-rich region binding IPI

Protein-protein interaction details for CYLD (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID PPIP5K1 Affinity Capture-Western physical 18636086 TBK1 Affinity Capture-Western physical 18636086 IKBKE Affinity Capture-Western physical 18636086 DDX58 Affinity Capture-Western physical 18636086 MAP3K7 Affinity Capture-Western physical 18332137 RIPK1 Affinity Capture-Western physical 17981138 PLK1 Affinity Capture-MS physical 17495026 PLK1 Affinity Capture-Western physical 17495026 CAMK2D Affinity Capture-MS physical 19615732 LOC220594 Affinity Capture-MS physical 19615732 USP13 Affinity Capture-MS physical 19615732 SPATA2 Affinity Capture-MS physical 19615732 MYO6 Affinity Capture-MS physical 19615732 SPATA2 Affinity Capture-MS physical 19615732 MGEA5 Affinity Capture-MS physical 19615732 Cep192 Affinity Capture-MS physical 19615732 SPATA2L Affinity Capture-MS physical 19615732 PMS2 Affinity Capture-MS physical 17148452 PMS1 Affinity Capture-Western physical 17148452 TRPA1 Affinity Capture-Western physical 16500080 BCL3 Affinity Capture-Western physical 19893491 HDAC6 Affinity Capture-Western physical 19893491 HDAC6 Reconstituted Complex physical 19893491 TRAIP Two-hybrid physical 14676304 TRAIP Far Western physical 14676304 IKBKG Two-hybrid physical 12917691 TRAF2 Two-hybrid physical 12917691 IKBKG Two-hybrid physical 12917691 TRAF2 Two-hybrid physical 12917691 IKBKG Affinity Capture-Western physical 12917691 TRAF2 Affinity Capture-Western physical 12917691 IKBKG Biochemical Activity physical 12917691 TRAF2 Biochemical Activity physical 12917691 TRAF6 Biochemical Activity physical 12917691 IKBKG Affinity Capture-Western physical 12917690 IKBKG Reconstituted Complex physical 12917689 IKBKG Affinity Capture-Western physical 16627981 OPTN Two-hybrid physical 21408173 OPTN Affinity Capture-Western physical 21408173 OPTN Reconstituted Complex physical 21408173 RIPK1 Affinity Capture-Western physical 21408173 DVL1 Affinity Capture-Western physical 20227366 DVL3 Affinity Capture-Western physical 20227366 SQSTM1 Affinity Capture-Western physical 19201866 SQSTM1 Affinity Capture-Western physical 19201866 ITCH Affinity Capture-Western physical 22057290 ITCH Affinity Capture-Western physical 22057290 ITCH Reconstituted Complex physical 22057290 UBC Affinity Capture-Western physical 17851586 UBC Biochemical Activity physical 17851586