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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for DNMT3B (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0006306 DNA methylation IEA GO:0006306 DNA methylation NAS GO:0006306 DNA methylation TAS GO:0006346 methylation-dependent chromatin silencing IEA GO:0006349 regulation of gene expression by genetic imprinting IEA GO:0010212 response to ionizing radiation IEA GO:0010424 DNA methylation on cytosine within a CG sequence IEA GO:0010628 positive regulation of gene expression IMP GO:0031503 protein complex localization IEA GO:0042493 response to drug IEA GO:0043045 DNA methylation involved in embryo development IEA GO:0045666 positive regulation of neuron differentiation IEA GO:0045814 negative regulation of gene expression, epigenetic IEA GO:0045892 negative regulation of transcription, DNA-dependent IEA GO:0046498 S-adenosylhomocysteine metabolic process IEA GO:0046499 S-adenosylmethioninamine metabolic process IEA GO:0051571 positive regulation of histone H3-K4 methylation IMP GO:0051573 negative regulation of histone H3-K9 methylation IMP GO:0071230 cellular response to amino acid stimulus IEA GO:0090116 C-5 methylation of cytosine IDA GO:0090116 C-5 methylation of cytosine NAS GO:0090116 C-5 methylation of cytosine TAS cellular_component GO:0000775 chromosome, centromeric region IEA GO:0005634 nucleus IDA GO:0005720 nuclear heterochromatin IEA GO:0005730 nucleolus IDA GO:0005737 cytoplasm IEA GO:0043231 intracellular membrane-bounded organelle IDA molecular_function GO:0003677 DNA binding IEA GO:0003714 transcription corepressor activity IMP GO:0003886 DNA (cytosine-5-)-methyltransferase activity IDA GO:0003886 DNA (cytosine-5-)-methyltransferase activity NAS GO:0003886 DNA (cytosine-5-)-methyltransferase activity TAS GO:0005515 protein binding IPI GO:0009008 DNA-methyltransferase activity NAS GO:0016740 transferase activity IEA GO:0045322 unmethylated CpG binding IEA GO:0046872 metal ion binding IEA GO:0051718 DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates IEA

Protein-protein interaction details for DNMT3B (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID SMC4 Co-purification physical 15148359 SMC2 Co-purification physical 15148359 KIF4A Co-purification physical 15148359 SIN3A Co-purification physical 15148359 HDAC1 Co-purification physical 15148359 SMARCA5 Co-purification physical 15148359 NCAPG Affinity Capture-Western physical 15148359 NCAPG Affinity Capture-Western physical 15148359 KIF4A Reconstituted Complex physical 15148359 NCAPG Reconstituted Complex physical 15148359 SMC2 Reconstituted Complex physical 15148359 DNMT3A Affinity Capture-Western physical 14752048 CBX5 Affinity Capture-Western physical 12867029 CBX5 Affinity Capture-Western physical 12867029 DNMT1 Affinity Capture-Western physical 12867029 DNMT3A Affinity Capture-Western physical 12867029 UBE2I Two-hybrid physical 11735126 SUMO1 Two-hybrid physical 11735126 UBE2I Reconstituted Complex physical 11735126 SUMO1 Reconstituted Complex physical 11735126 DNMT3L Affinity Capture-Western physical 11934864 DNMT1 Affinity Capture-Western physical 12145218 DNMT3A Affinity Capture-Western physical 12145218 DNMT1 Reconstituted Complex physical 12145218 DNMT3A Reconstituted Complex physical 12145218 SPI1 Affinity Capture-Western physical 16331260 SPI1 Reconstituted Complex physical 16331260 HDAC1 Reconstituted Complex physical 16331260 TDG Affinity Capture-Western physical 18452947 TDG Reconstituted Complex physical 18452947 MBD4 Reconstituted Complex physical 18452947 UHRF1 Affinity Capture-Western physical 19798101 UHRF1 Affinity Capture-Western physical 19798101 SETDB1 Affinity Capture-Western physical 16682412 EZH2 Reconstituted Complex physical 16357870 EZH2 Affinity Capture-Western physical 16357870 EZH2 Affinity Capture-Western physical 16357870 EED Affinity Capture-Western physical 16357870 EED Co-localization physical 16357870 BAZ2A Reconstituted Complex physical 16085498 HDAC1 Affinity Capture-Western physical 15120635 HDAC2 Affinity Capture-Western physical 15120635 CBX5 Affinity Capture-Western physical 15120635 SMARCA5 Affinity Capture-Western physical 15120635 SMARCA5 Affinity Capture-Western physical 15120635 HDAC1 Reconstituted Complex physical 15120635 HDAC2 Reconstituted Complex physical 15120635 SUV39H1 Reconstituted Complex physical 15120635 SMARCA5 Reconstituted Complex physical 15120635 SMARCA5 Reconstituted Complex physical 15120635 CBX5 Reconstituted Complex physical 15120635 CBX3 Reconstituted Complex physical 15120635 SUV39H1 Reconstituted Complex physical 15120635 DNMT1 Affinity Capture-Western physical 15120635 HELLS Affinity Capture-Western physical 17967891 HELLS Reconstituted Complex physical 17967891 DNMT3L Reconstituted Complex physical 17687327 DNMT3A Affinity Capture-MS physical 20923784 HIST1H1A Affinity Capture-MS physical 20923784 DNMT3A Affinity Capture-Western physical 20923784 HIST1H1A Affinity Capture-Western physical 20923784 CBX5 Affinity Capture-Western physical 20923784 CBX1 Affinity Capture-Western physical 20923784 CBX3 Affinity Capture-Western physical 20923784 NEDD8 Affinity Capture-Western physical 20847044 NEDD8 Affinity Capture-Western physical 20847044 NEDD8 Reconstituted Complex physical 20847044 CUL1 Affinity Capture-Western physical 20847044 CUL2 Affinity Capture-Western physical 20847044 CUL3 Affinity Capture-Western physical 20847044 CUL5 Affinity Capture-Western physical 20847044 CUL4A Affinity Capture-Western physical 20847044 PIAS1 Affinity Capture-Western physical 20966256 PIAS1 Co-localization physical 20966256 CMTM6 Two-hybrid physical 21900206 PCYT2 Two-hybrid physical 21900206 RPS10 Two-hybrid physical 21900206 TIMM16 Two-hybrid physical 21900206 PLEKHJ1 Two-hybrid physical 21900206 DUSP23 Two-hybrid physical 21900206 MAP1LC3B Two-hybrid physical 21900206 UBE2W Two-hybrid physical 21900206 WARS Two-hybrid physical 21900206 TSC22D1 Two-hybrid physical 21900206