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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for E2F1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000080 G1 phase of mitotic cell cycle TAS GO:0000082 G1/S transition of mitotic cell cycle TAS GO:0000085 G2 phase of mitotic cell cycle TAS GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP GO:0000278 mitotic cell cycle TAS GO:0006351 transcription, DNA-dependent IDA GO:0006351 transcription, DNA-dependent TAS GO:0006355 regulation of transcription, DNA-dependent IDA GO:0006915 apoptosis IEA GO:0007283 spermatogenesis IEA GO:0008283 cell proliferation TAS GO:0010628 positive regulation of gene expression IDA GO:0030900 forebrain development IEA GO:0045892 negative regulation of transcription, DNA-dependent IMP GO:0045893 positive regulation of transcription, DNA-dependent IMP GO:0045944 positive regulation of transcription from RNA polymerase II promoter IMP GO:0048146 positive regulation of fibroblast proliferation IMP GO:0048255 mRNA stabilization IDA GO:0051726 regulation of cell cycle IEA GO:0071398 cellular response to fatty acid IEA GO:0071456 cellular response to hypoxia IEA GO:0071930 negative regulation of transcription involved in G1/S phase of mitotic cell cycle IMP GO:2000045 regulation of G1/S transition of mitotic cell cycle IMP cellular_component GO:0005634 nucleus IDA GO:0005654 nucleoplasm TAS GO:0005737 cytoplasm IEA GO:0005739 mitochondrion IDA GO:0035189 Rb-E2F complex IDA molecular_function GO:0003677 DNA binding IDA GO:0003677 DNA binding IMP GO:0003700 sequence-specific DNA binding transcription factor activity IDA GO:0003700 sequence-specific DNA binding transcription factor activity TAS GO:0003714 transcription corepressor activity TAS GO:0004693 cyclin-dependent protein kinase activity TAS GO:0005515 protein binding IPI GO:0008134 transcription factor binding IPI GO:0043565 sequence-specific DNA binding IEA

Protein-protein interaction details for E2F1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID NDN Two-hybrid physical 9422723 NCOA6 Two-hybrid physical 14638867 NCOA6 Affinity Capture-Western physical 14638867 NCOA6 Reconstituted Complex physical 14638867 TOPBP1 Affinity Capture-Western physical 12697828 TOPBP1 Two-hybrid physical 12697828 PHB Reconstituted Complex physical 14637159 PHB Affinity Capture-Western physical 14637159 NDN Affinity Capture-Western physical 14593116 NDNL2 Affinity Capture-Western physical 14593116 NDN Two-hybrid physical 14593116 NDNL2 Reconstituted Complex physical 14593116 NDN Reconstituted Complex physical 14593116 TOPBP1 Reconstituted Complex physical 14576433 PHB Co-localization physical 14500729 PHB Affinity Capture-Western physical 14500729 PKIB Two-hybrid physical 12748276 CREBBP Two-hybrid physical 12748276 TEAD3 Two-hybrid physical 12748276 MYBL2 Two-hybrid physical 12748276 SPIB Two-hybrid physical 12748276 MGA Two-hybrid physical 12748276 TOPBP1 Reconstituted Complex physical 12697828 RB1 Affinity Capture-Western physical 11470869 RB1 Affinity Capture-Western physical 12397079 TRRAP Affinity Capture-Western physical 9708738 DNMT1 Co-fractionation physical 10888886 PHB Affinity Capture-Western physical 12065415 PHB Affinity Capture-Western physical 12065415 HDAC1 Affinity Capture-Western physical 10734134 RBBP4 Affinity Capture-Western physical 10734134 RING1 Affinity Capture-Western physical 11583618 TP53BP1 Reconstituted Complex physical 8896460 TP53BP1 Reconstituted Complex physical 8896460 TP53BP1 Affinity Capture-Western physical 8896460 RB1 Reconstituted Complex physical 8896460 MDM4 Two-hybrid physical 12532331 MDM4 Reconstituted Complex physical 12532331 SP1 Affinity Capture-Western physical 8657142 SP1 Reconstituted Complex physical 8657142 RNF144A Two-hybrid physical 12411495 FHL2 Two-hybrid physical 12411495 CDK2 Reconstituted Complex physical 7969176 CCNA2 Affinity Capture-Western physical 7969176 CCNA2 Reconstituted Complex physical 7969176 SP1 Affinity Capture-Western physical 10547281 SP2 Affinity Capture-Western physical 10547281 SP4 Affinity Capture-Western physical 10547281 SP3 Affinity Capture-Western physical 10547281 SP3 Reconstituted Complex physical 10547281 SP2 Reconstituted Complex physical 10547281 SP4 Reconstituted Complex physical 10547281 SP1 Reconstituted Complex physical 10547281 RB1 Two-hybrid physical 10869426 NPDC1 Reconstituted Complex physical 11042687 NPDC1 Two-hybrid physical 11042687 RBL1 Affinity Capture-Western physical 8230483 RB1 Reconstituted Complex physical 8230483 RBL1 Reconstituted Complex physical 8230483 RB1 Affinity Capture-Western physical 8230483 TFDP1 Two-hybrid physical 7892279 NFKB1 Reconstituted Complex physical 9368006 PHB Reconstituted Complex physical 10523633 PHB Affinity Capture-Western physical 10523633 ARID3A Reconstituted Complex physical 9780002 ARID3A Affinity Capture-Western physical 9780002 TFDP1 Affinity Capture-Western physical 9780002 CCNA1 Reconstituted Complex physical 10022926 CCNA1 Affinity Capture-Western physical 10022926 RB1 Reconstituted Complex physical 7739537 TFDP1 Reconstituted Complex physical 7739537 TFDP2 Reconstituted Complex physical 7739537 TFDP1 Reconstituted Complex physical 8405995 TFDP1 Affinity Capture-Western physical 8405995 SP1 Reconstituted Complex physical 8657141 SP1 Reconstituted Complex physical 8657141 SKP2 Affinity Capture-Western physical 10559858 CUL1 Affinity Capture-Western physical 10559858 SKP2 Reconstituted Complex physical 10559858 CUL1 Reconstituted Complex physical 10559858 GTF2H1 Biochemical Activity physical 10428966 CDK7 Affinity Capture-Western physical 10428966 GTF2H1 Affinity Capture-Western physical 10428966 BRD2 Co-purification physical 10965846 PURA Reconstituted Complex physical 10597240 PURA Reconstituted Complex physical 10597240 RB1 Two-hybrid physical 9422723 NDN Affinity Capture-Western physical 9422723 NDN Affinity Capture-Western physical 9422723 GSK3B Affinity Capture-Western physical 18367454 UBC Affinity Capture-Western physical 18367454 UBC Affinity Capture-Western physical 18367454 CDT1 Affinity Capture-Western physical 18162579 UBC Affinity Capture-Western physical 17630509 RB1 Affinity Capture-Western physical 12963846 CCNA1 Reconstituted Complex physical 16774918 SIRT1 Affinity Capture-Western physical 19188449 KAT2B Affinity Capture-Western physical 19188449 UBC Affinity Capture-Western physical 16170383 MDM2 Affinity Capture-Western physical 16170383 MDM2 Affinity Capture-Western physical 16170383 SKP2 Affinity Capture-Western physical 16170383 BRD2 Affinity Capture-Western physical 17111193 TBP Affinity Capture-Western physical 17111193 BRD2 Affinity Capture-Western physical 17111193 TFDP1 Reconstituted Complex physical 19015639 TFDP1 Reconstituted Complex physical 19015639 UBC Affinity Capture-Western physical 15917652 YWHAQ Two-hybrid physical 15494392 YWHAQ Reconstituted Complex physical 15494392 YWHAQ Affinity Capture-Western physical 15494392 UBC Affinity Capture-Western physical 15494392 RB1 Affinity Capture-Western physical 16766265 RB1 Affinity Capture-Western physical 16766265 MCPH1 Affinity Capture-Western physical 18660752 MCPH1 Affinity Capture-Western physical 18660752 E2F4 Co-localization physical 16357170 KLF6 Affinity Capture-Western physical 18521079 RB1 Affinity Capture-Western physical 11839806 SKP2 Affinity Capture-Western physical 12097298 UBC Affinity Capture-Western physical 12097298 CDKN1A Co-localization physical 15964998 RB1 Affinity Capture-Western physical 15670817 TRRAP Affinity Capture-Western physical 11418595 KAT2A Affinity Capture-Western physical 11418595 RB1 Affinity Capture-Western physical 18216119 RB1 Affinity Capture-Western physical 15485920 SP1 Reconstituted Complex physical 10409740 PHB Affinity Capture-Western physical 15141164 PHB Affinity Capture-Western physical 15141164 KAT5 Affinity Capture-Western physical 15121871 KAT5 Affinity Capture-Western physical 15121871 LEF1 Affinity Capture-Western physical 17980157 HDAC1 Affinity Capture-Western physical 17980157 TRIM28 Affinity Capture-Western physical 17704056 RBX1 Biochemical Activity physical 11245432 CUL1 Biochemical Activity physical 11245432 UBC Affinity Capture-Western physical 11245432 HCFC1 Affinity Capture-Western physical 17612494 HCFC1 Two-hybrid physical 17612494 ASH2L Affinity Capture-Western physical 17612494 TOPBP1 Affinity Capture-Western physical 20413589 NRIP1 Affinity Capture-Western physical 20410059 NRIP1 Reconstituted Complex physical 20410059 NRIP1 Reconstituted Complex physical 20410059 NRIP1 Affinity Capture-Western physical 20410059 KDM1A Biochemical Activity physical 20603083 SETD7 Biochemical Activity physical 20603083 PRDM2 Reconstituted Complex physical 9223517 UBC Affinity Capture-Western physical 16924238 ATM Biochemical Activity physical 11459832 ATR Biochemical Activity physical 11459832 ATAD2 Affinity Capture-Western physical 20855524 ATAD2 Reconstituted Complex physical 20855524 CSNK1A1 Affinity Capture-Western physical 19759023