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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for GHR (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000187 activation of MAPK activity IEA GO:0000187 activation of MAPK activity ISS GO:0000255 allantoin metabolic process ISS GO:0006101 citrate metabolic process ISS GO:0006103 2-oxoglutarate metabolic process ISS GO:0006105 succinate metabolic process ISS GO:0006107 oxaloacetate metabolic process ISS GO:0006549 isoleucine metabolic process ISS GO:0006573 valine metabolic process ISS GO:0006600 creatine metabolic process ISS GO:0006631 fatty acid metabolic process ISS GO:0006897 endocytosis IEA GO:0007259 JAK-STAT cascade ISS GO:0009755 hormone-mediated signaling pathway IEA GO:0019530 taurine metabolic process ISS GO:0031623 receptor internalization IDA GO:0032094 response to food IEA GO:0032355 response to estradiol stimulus IDA GO:0032869 cellular response to insulin stimulus IEA GO:0032870 cellular response to hormone stimulus IMP GO:0040014 regulation of multicellular organism growth ISS GO:0040018 positive regulation of multicellular organism growth IMP GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein ISS GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein ISS GO:0042977 activation of JAK2 kinase activity IEA GO:0042977 activation of JAK2 kinase activity ISS GO:0043278 response to morphine IEA GO:0043434 response to peptide hormone stimulus IEA GO:0043526 neuroprotection IEA GO:0044236 multicellular organismal metabolic process IMP GO:0045597 positive regulation of cell differentiation IEA GO:0046427 positive regulation of JAK-STAT cascade IEA GO:0046449 creatinine metabolic process ISS GO:0046898 response to cycloheximide IDA GO:0048009 insulin-like growth factor receptor signaling pathway IMP GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ISS GO:0051384 response to glucocorticoid stimulus IEA GO:0060351 cartilage development involved in endochondral bone morphogenesis IEA GO:0060396 growth hormone receptor signaling pathway IMP GO:0070555 response to interleukin-1 IEA cellular_component GO:0005576 extracellular region IEA GO:0005615 extracellular space IDA GO:0005615 extracellular space IMP GO:0005634 nucleus IEA GO:0005737 cytoplasm IEA GO:0005739 mitochondrion IEA GO:0005886 plasma membrane IEA GO:0005887 integral to plasma membrane IDA GO:0009986 cell surface IDA GO:0016020 membrane IEA GO:0016021 integral to membrane IDA GO:0019898 extrinsic to membrane IEA GO:0043025 neuronal cell body IEA GO:0043235 receptor complex IDA GO:0070195 growth hormone receptor complex IDA molecular_function GO:0004872 receptor activity IEA GO:0004896 cytokine receptor activity IEA GO:0004903 growth hormone receptor activity IEA GO:0005515 protein binding IPI GO:0017046 peptide hormone binding IEA GO:0017046 peptide hormone binding IPI GO:0019838 growth factor binding IPI GO:0019901 protein kinase binding IEA GO:0019901 protein kinase binding ISS GO:0019903 protein phosphatase binding IEA GO:0042169 SH2 domain binding IEA GO:0042803 protein homodimerization activity IDA GO:0070064 proline-rich region binding ISS

Protein-protein interaction details for GHR (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID SGTA Reconstituted Complex physical 12735788 SGTA Affinity Capture-Western physical 12735788 SGTA Affinity Capture-MS physical 12735788 JAK2 Affinity Capture-Western physical 7540178 CISH Affinity Capture-Western physical 10585430 SOCS1 Affinity Capture-Western physical 10585430 SOCS1 Reconstituted Complex physical 10585430 SOCS3 Reconstituted Complex physical 10585430 SOCS2 Reconstituted Complex physical 10585430 CISH Reconstituted Complex physical 10585430 GH1 Reconstituted Complex physical 7862673 PTPN11 Reconstituted Complex physical 10976913 SHC1 Reconstituted Complex physical 7535773 GRB2 Reconstituted Complex physical 9632636 PIK3R1 Reconstituted Complex physical 9632636 PTPN11 Reconstituted Complex physical 9632636 PLCG1 Reconstituted Complex physical 9632636 GRB10 Affinity Capture-Western physical 9632636 STAT3 Reconstituted Complex physical 8923468 STAT5B Reconstituted Complex physical 8923468 JAK2 Affinity Capture-Western physical 8063815 JAK1 Affinity Capture-Western physical 10502458 JAK2 Affinity Capture-Western physical 10502458 TYK2 Affinity Capture-Western physical 10502458 GH1 Reconstituted Complex physical 17500058 BTRC Reconstituted Complex physical 17500058 PTPN2 Reconstituted Complex physical 12907755 PTPRB Reconstituted Complex physical 12907755 PTPN1 Reconstituted Complex physical 12907755 PTPRH Reconstituted Complex physical 12907755 DUSP7 Reconstituted Complex physical 12907755 PTPN9 Reconstituted Complex physical 12907755 PTPN3 Reconstituted Complex physical 12907755 PTPN3 Far Western physical 12907755 PTPN1 Far Western physical 12907755 PTPN2 Far Western physical 12907755 PTPRH Far Western physical 12907755 PTPN9 Far Western physical 12907755 PTPN13 Far Western physical 12907755 SOCS2 Biochemical Activity physical 21980433