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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for GLI1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0001649 osteoblast differentiation IDA GO:0007224 smoothened signaling pathway IDA GO:0007275 multicellular organismal development IEA GO:0008284 positive regulation of cell proliferation IMP GO:0008589 regulation of smoothened signaling pathway TAS GO:0009913 epidermal cell differentiation IDA GO:0045740 positive regulation of DNA replication IDA GO:0045880 positive regulation of smoothened signaling pathway IDA GO:0045893 positive regulation of transcription, DNA-dependent IDA GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA GO:0090090 negative regulation of canonical Wnt receptor signaling pathway IMP cellular_component GO:0005622 intracellular IEA GO:0005634 nucleus IDA GO:0005737 cytoplasm IDA GO:0005829 cytosol IDA molecular_function GO:0003676 nucleic acid binding IEA GO:0003677 DNA binding IDA GO:0005515 protein binding IPI GO:0008270 zinc ion binding IEA GO:0044212 transcription regulatory region DNA binding IDA GO:0046872 metal ion binding IEA

Protein-protein interaction details for GLI1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID SUFU Affinity Capture-Western physical 10564661 SUFU Reconstituted Complex physical 10564661 SUFU Affinity Capture-Western physical 10559945 SUFU Reconstituted Complex physical 10559945 ZIC1 Affinity Capture-Western physical 11238441 ZIC2 Affinity Capture-Western physical 11238441 ZIC1 Reconstituted Complex physical 11238441 STK36 Affinity Capture-Western physical 10806483 STK36 Co-localization physical 10806483 SUFU Reconstituted Complex physical 12426310 SUFU Affinity Capture-Western physical 12426310 SUFU Affinity Capture-Western physical 12426310 SUFU Far Western physical 12426310 SAP18 Affinity Capture-Western physical 11960000 SAP18 Phenotypic Suppression genetic 11960000 HDAC1 Affinity Capture-Western physical 20081843 HDAC1 Affinity Capture-Western physical 20081843 HDAC2 Affinity Capture-Western physical 20081843 XBP1 Two-hybrid physical 20211142 RAI1 Two-hybrid physical 20211142 SUFU Affinity Capture-Western physical 21543335 ITCH Affinity Capture-Western physical 20818436 ITCH Reconstituted Complex physical 20818436 ITCH Reconstituted Complex physical 20818436 ITCH Biochemical Activity physical 20818436 ITCH Affinity Capture-Western physical 20818436 UBC Affinity Capture-Western physical 20818436 NUMB Reconstituted Complex physical 20818436 NUMB Affinity Capture-Western physical 20818436