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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for APC (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000281 cytokinesis after mitosis IEA GO:0000281 cytokinesis after mitosis IMP GO:0001822 kidney development IEA GO:0001942 hair follicle development IEA GO:0006461 protein complex assembly IDA GO:0006915 apoptosis TAS GO:0006921 cellular component disassembly involved in apoptosis TAS GO:0006974 response to DNA damage stimulus IDA GO:0007026 negative regulation of microtubule depolymerization IDA GO:0007026 negative regulation of microtubule depolymerization IEA GO:0007026 negative regulation of microtubule depolymerization IMP GO:0007050 cell cycle arrest IDA GO:0007091 mitotic metaphase/anaphase transition IEA GO:0007094 mitotic cell cycle spindle assembly checkpoint IMP GO:0007155 cell adhesion NAS GO:0007163 establishment or maintenance of cell polarity IEA GO:0007409 axonogenesis IEA GO:0008285 negative regulation of cell proliferation IDA GO:0009798 axis specification IEA GO:0009952 anterior/posterior pattern specification IEA GO:0009953 dorsal/ventral pattern formation IEA GO:0009954 proximal/distal pattern formation IEA GO:0016055 Wnt receptor signaling pathway IEA GO:0016477 cell migration IMP GO:0030178 negative regulation of Wnt receptor signaling pathway IEA GO:0030335 positive regulation of cell migration IEA GO:0030335 positive regulation of cell migration IMP GO:0030858 positive regulation of epithelial cell differentiation IEA GO:0031016 pancreas development IEA GO:0031116 positive regulation of microtubule polymerization IEA GO:0031122 cytoplasmic microtubule organization IEA GO:0031175 neuron projection development IEA GO:0031274 positive regulation of pseudopodium assembly IMP GO:0032886 regulation of microtubule-based process IMP GO:0033077 T cell differentiation in thymus IEA GO:0035019 somatic stem cell maintenance IEA GO:0042483 negative regulation of odontogenesis IEA GO:0042493 response to drug IEA GO:0043065 positive regulation of apoptosis IEA GO:0043065 positive regulation of apoptosis IMP GO:0043066 negative regulation of apoptosis IEA GO:0043409 negative regulation of MAPKKK cascade IEA GO:0043588 skin development IEA GO:0045667 regulation of osteoblast differentiation IEA GO:0045670 regulation of osteoclast differentiation IEA GO:0045732 positive regulation of protein catabolic process IC GO:0045732 positive regulation of protein catabolic process IEA GO:0045732 positive regulation of protein catabolic process IGI GO:0045736 negative regulation of cyclin-dependent protein kinase activity IDA GO:0045785 positive regulation of cell adhesion IEA GO:0046716 muscle cell homeostasis IEA GO:0048538 thymus development IEA GO:0051171 regulation of nitrogen compound metabolic process IEA GO:0051276 chromosome organization IEA GO:0051726 regulation of cell cycle IEA GO:0051781 positive regulation of cell division IEA GO:0051988 regulation of attachment of spindle microtubules to kinetochore IEA GO:0051988 regulation of attachment of spindle microtubules to kinetochore IMP GO:0051988 regulation of attachment of spindle microtubules to kinetochore NAS GO:0060041 retina development in camera-type eye IEA GO:0060070 canonical Wnt receptor signaling pathway IC GO:0060070 canonical Wnt receptor signaling pathway IEA GO:0060070 canonical Wnt receptor signaling pathway NAS GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development IEA GO:0070830 tight junction assembly NAS GO:0090090 negative regulation of canonical Wnt receptor signaling pathway IGI cellular_component GO:0000776 kinetochore IDA GO:0005634 nucleus IDA GO:0005634 nucleus IEA GO:0005737 cytoplasm IDA GO:0005737 cytoplasm IEA GO:0005813 centrosome IDA GO:0005829 cytosol TAS GO:0005856 cytoskeleton IEA GO:0005881 cytoplasmic microtubule IEA GO:0005886 plasma membrane IDA GO:0005913 cell-cell adherens junction IDA GO:0005923 tight junction IDA GO:0016328 lateral plasma membrane IDA GO:0030027 lamellipodium IDA GO:0030054 cell junction IEA GO:0030877 beta-catenin destruction complex IDA GO:0031253 cell projection membrane IEA GO:0032587 ruffle membrane IDA GO:0034742 APC-Axin-1-beta-catenin complex IDA GO:0034747 Axin-APC-beta-catenin-GSK3B complex IDA GO:0035371 microtubule plus end IEA GO:0043025 neuronal cell body IEA GO:0044295 axonal growth cone IEA GO:0045202 synapse IEA molecular_function GO:0005488 binding IEA GO:0005515 protein binding IPI GO:0008013 beta-catenin binding IEA GO:0008013 beta-catenin binding IPI GO:0008017 microtubule binding IDA GO:0019887 protein kinase regulator activity IDA GO:0019901 protein kinase binding IPI GO:0045295 gamma-catenin binding IPI GO:0045296 cadherin binding IDA GO:0051010 microtubule plus-end binding IDA GO:0051010 microtubule plus-end binding IEA

Protein-protein interaction details for APC (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID CTNNA1 Affinity Capture-Western physical 8259519 CTNNB1 Affinity Capture-Western physical 8259519 CTNNB1 Far Western physical 8259519 MUC1 Affinity Capture-Western physical 15020226 PPP2R5A Co-localization physical 11585828 TUBA4A Co-localization physical 11166179 TUBA4A Reconstituted Complex physical 11166179 XPO1 Affinity Capture-Western physical 12070164 APC Affinity Capture-Western physical 8389242 TFAP2A Affinity Capture-Western physical 15331612 TFAP2A Affinity Capture-Western physical 15331612 CTNNB1 Affinity Capture-Western physical 11712088 MAPRE2 Two-hybrid physical 7606712 CSNK2A1 Affinity Capture-Western physical 11972058 CSNK2B Affinity Capture-Western physical 11972058 SFN Affinity Capture-MS physical 15778465 CTNNB1 Reconstituted Complex physical 12628243 AXIN1 Reconstituted Complex physical 9734785 AXIN1 Two-hybrid physical 9734785 AXIN1 Reconstituted Complex physical 9734785 AXIN1 Two-hybrid physical 9734785 TFAP2A Reconstituted Complex physical 15331612 APC Reconstituted Complex physical 8389242 APC Reconstituted Complex physical 12070164 CTNNB1 Affinity Capture-Western physical 11251183 XPO1 Reconstituted Complex physical 12070164 CTNNB1 Affinity Capture-Western physical 11533658 GSK3B Affinity Capture-Western physical 11251183 KIFAP3 Affinity Capture-Western physical 11912492 DLG3 Reconstituted Complex physical 9188857 JUP Reconstituted Complex physical 8074697 CTNNB1 Affinity Capture-Western physical 11972058 CTNNB1 Reconstituted Complex physical 12628243 MAPRE2 Reconstituted Complex physical 11470413 CSNK2A1 Affinity Capture-Western physical 11972058 CSNK2A1 Reconstituted Complex physical 11972058 CSNK2B Affinity Capture-Western physical 11972058 CTNNA1 Affinity Capture-Western physical 7651399 CTNNB1 Affinity Capture-Western physical 11251183 DLG3 Two-hybrid physical 9188857 MAPRE2 Reconstituted Complex physical 7606712 MAPRE2 Affinity Capture-Western physical 7606712 JUP Affinity Capture-Western physical 7651399 KIFAP3 Reconstituted Complex physical 11912492 KIFAP3 Two-hybrid physical 11912492 SIAH1 Reconstituted Complex physical 11389840 SIAH1 Affinity Capture-Western physical 11389840 MAPRE1 Reconstituted Complex physical 12388762 DLGAP1 Affinity Capture-Western physical 9286858 CTNNB1 Affinity Capture-Western physical 9286858 ARHGEF4 Reconstituted Complex physical 10947987 ARHGEF4 Affinity Capture-Western physical 10947987 CTNNB1 Reconstituted Complex physical 11707392 CTNNB1 Co-crystal Structure physical 11707392 MAD2L1 Affinity Capture-Western physical 9637688 BUB1 Affinity Capture-Western physical 11283619 BUB3 Affinity Capture-Western physical 11283619 BUB1 Biochemical Activity physical 11283619 BUB1B Biochemical Activity physical 11283619 AXIN2 Affinity Capture-Western physical 10966653 CSNK1A1 Biochemical Activity physical 19426738 BTRC Affinity Capture-MS physical 19615732 CTNNB1 Reconstituted Complex physical 16510874 AXIN1 Affinity Capture-Western physical 16199882 ACTN1 Two-hybrid physical 20936779 AP2B1 Two-hybrid physical 20936779 ANXA7 Two-hybrid physical 20936779 DST Two-hybrid physical 20936779 C4A Two-hybrid physical 20936779 CREBBP Two-hybrid physical 20936779 CTNNA1 Two-hybrid physical 20936779 EPAS1 Two-hybrid physical 20936779 FLNA Two-hybrid physical 20936779 GOLGA2 Two-hybrid physical 20936779 AGFG1 Two-hybrid physical 20936779 HSPA5 Two-hybrid physical 20936779 JUP Two-hybrid physical 20936779 KIF5B Two-hybrid physical 20936779 KRT5 Two-hybrid physical 20936779 KRT13 Two-hybrid physical 20936779 KRT14 Two-hybrid physical 20936779 KRT15 Two-hybrid physical 20936779 KRT17 Two-hybrid physical 20936779 KRT19 Two-hybrid physical 20936779 LAMA3 Two-hybrid physical 20936779 LAMA4 Two-hybrid physical 20936779 ND4 Two-hybrid physical 20936779 MYH10 Two-hybrid physical 20936779 MYH11 Two-hybrid physical 20936779 MYO6 Two-hybrid physical 20936779 HNRNPM Two-hybrid physical 20936779 NEB Two-hybrid physical 20936779 NUP98 Two-hybrid physical 20936779 PSMD1 Two-hybrid physical 20936779 RANBP2 Two-hybrid physical 20936779 RPS27 Two-hybrid physical 20936779 SPTBN1 Two-hybrid physical 20936779 SPTBN2 Two-hybrid physical 20936779 TRIM21 Two-hybrid physical 20936779 TAF1 Two-hybrid physical 20936779 TPR Two-hybrid physical 20936779 NUP214 Two-hybrid physical 20936779 MCM3AP Two-hybrid physical 20936779 SMC3 Two-hybrid physical 20936779 HGS Two-hybrid physical 20936779 CYTH2 Two-hybrid physical 20936779 NUPL1 Two-hybrid physical 20936779 SETDB1 Two-hybrid physical 20936779 POM121 Two-hybrid physical 20936779 NUP153 Two-hybrid physical 20936779 RANBP9 Two-hybrid physical 20936779 COG5 Two-hybrid physical 20936779 NUPL2 Two-hybrid physical 20936779 LPHN1 Two-hybrid physical 20936779 SEC31A Two-hybrid physical 20936779 SNRNP200 Two-hybrid physical 20936779 EXPH5 Two-hybrid physical 20936779 SYNE1 Two-hybrid physical 20936779 PPP1R13B Two-hybrid physical 20936779 CYTSA Two-hybrid physical 20936779 MACF1 Two-hybrid physical 20936779 COG4 Two-hybrid physical 20936779 SFRS18 Two-hybrid physical 20936779 KRT23 Two-hybrid physical 20936779 ANKRD17 Two-hybrid physical 20936779 GIGYF2 Two-hybrid physical 20936779 FHOD1 Two-hybrid physical 20936779 NUP54 Two-hybrid physical 20936779 MBD5 Two-hybrid physical 20936779 ERBB2IP Two-hybrid physical 20936779 KIAA1370 Two-hybrid physical 20936779 KIAA1328 Two-hybrid physical 20936779 ZFP106 Two-hybrid physical 20936779 RBM4B Two-hybrid physical 20936779 FBXO30 Two-hybrid physical 20936779 ING5 Two-hybrid physical 20936779 CGNL1 Two-hybrid physical 20936779 NAV3 Two-hybrid physical 20936779 NAV1 Two-hybrid physical 20936779 NAV2 Two-hybrid physical 20936779 NOSTRIN Two-hybrid physical 20936779 NCKAP5L Two-hybrid physical 20936779 NCKAP5 Two-hybrid physical 20936779 POM121C Two-hybrid physical 20936779 UBC Affinity Capture-Western physical 15355978 CTNNB1 Affinity Capture-Western physical 15355978 CTBP1 Affinity Capture-Western physical 16510875 BTRC Affinity Capture-Western physical 10228155 AXIN1 Affinity Capture-Western physical 10228155 UBC Affinity Capture-MS physical 16196087 BTRC Affinity Capture-Western physical 10074433 YWHAQ Affinity Capture-MS physical 15161933 PSMD4 Biochemical Activity physical 19240029 ZRANB1 Affinity Capture-Western physical 18281465 ZRANB1 Co-localization physical 18281465 UBC Affinity Capture-Western physical 18281465