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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for HRAS (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000165 MAPKKK cascade TAS GO:0000186 activation of MAPKK activity TAS GO:0006897 endocytosis IEA GO:0006915 apoptosis IEA GO:0006935 chemotaxis TAS GO:0007050 cell cycle arrest IDA GO:0007050 cell cycle arrest IMP GO:0007165 signal transduction NAS GO:0007166 cell surface receptor linked signaling pathway TAS GO:0007173 epidermal growth factor receptor signaling pathway TAS GO:0007264 small GTPase mediated signal transduction TAS GO:0007265 Ras protein signal transduction TAS GO:0007268 synaptic transmission TAS GO:0007411 axon guidance TAS GO:0007596 blood coagulation TAS GO:0008284 positive regulation of cell proliferation IDA GO:0008285 negative regulation of cell proliferation IDA GO:0008286 insulin receptor signaling pathway TAS GO:0008542 visual learning IEA GO:0008629 induction of apoptosis by intracellular signals IEA GO:0009887 organ morphogenesis TAS GO:0030036 actin cytoskeleton organization IEA GO:0031575 mitotic cell cycle G1/S transition checkpoint IDA GO:0032228 regulation of synaptic transmission, GABAergic IEA GO:0035022 positive regulation of Rac protein signal transduction IEA GO:0035176 social behavior IEA GO:0043410 positive regulation of MAPKKK cascade IDA GO:0043524 negative regulation of neuron apoptosis IEA GO:0045740 positive regulation of DNA replication IDA GO:0048011 nerve growth factor receptor signaling pathway TAS GO:0048169 regulation of long-term neuronal synaptic plasticity IEA GO:0050679 positive regulation of epithelial cell proliferation IMP GO:0050900 leukocyte migration TAS GO:0051146 striated muscle cell differentiation IEA GO:0070374 positive regulation of ERK1 and ERK2 cascade IEA GO:0090398 cellular senescence IDA cellular_component GO:0000139 Golgi membrane IEA GO:0005624 membrane fraction IEA GO:0005625 soluble fraction IEA GO:0005634 nucleus IEA GO:0005737 cytoplasm IEA GO:0005792 microsome IEA GO:0005794 Golgi apparatus IEA GO:0005829 cytosol TAS GO:0005886 plasma membrane TAS GO:0048471 perinuclear region of cytoplasm IEA molecular_function GO:0000166 nucleotide binding IEA GO:0003924 GTPase activity IEA GO:0005515 protein binding IPI GO:0005525 GTP binding IDA GO:0008022 protein C-terminus binding IPI GO:0008321 Ral guanyl-nucleotide exchange factor activity TAS

Protein-protein interaction details for HRAS (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID RAP1GDS1 Two-hybrid physical 11948427 BRAF Two-hybrid physical 9154803 RASGRF1 Two-hybrid physical 9154803 RAF1 Two-hybrid physical 9154803 RGL4 Two-hybrid physical 9154803 RAF1 Two-hybrid physical 14654780 RIN1 Two-hybrid physical 15031288 RALGDS Two-hybrid physical 15031288 RASIP1 Two-hybrid physical 15031288 RGL2 Two-hybrid physical 15031288 RASIP1 Reconstituted Complex physical 15031288 RAF1 Reconstituted Complex physical 15031288 RASIP1 Affinity Capture-Western physical 15031288 RAF1 Reconstituted Complex physical 14724584 PIK3CA Reconstituted Complex physical 14724584 RGL4 Reconstituted Complex physical 12874025 TTC1 Affinity Capture-Western physical 12748287 GPSM2 Affinity Capture-Western physical 12748287 SOS1 Co-crystal Structure physical 12628188 RAF1 Two-hybrid physical 12620389 ARHGEF1 Biochemical Activity physical 12581858 RASSF1 Reconstituted Complex physical 10998413 RASSF1 Affinity Capture-Western physical 10998413 RAF1 Two-hybrid physical 10783161 SHOC2 Two-hybrid physical 10783161 PIK3CA Two-hybrid physical 10783161 RALGDS Two-hybrid physical 10783161 SHOC2 Affinity Capture-Western physical 10783161 SHOC2 Affinity Capture-Western physical 10783161 RAF1 Reconstituted Complex physical 10783161 SHOC2 Reconstituted Complex physical 10783161 PDE6D Two-hybrid physical 11980706 SOS1 Co-crystal Structure physical 9690470 TIAM1 Affinity Capture-Western physical 12134164 BRAF Reconstituted Complex physical 7706312 RASSF5 Reconstituted Complex physical 9488663 RAF1 Affinity Capture-Western physical 10882715 RAF1 Two-hybrid physical 9523700 MLLT4 Two-hybrid physical 10922060 RALGDS Two-hybrid physical 10922060 PIK3CD Two-hybrid physical 10922060 RAF1 Two-hybrid physical 10922060 INSR Biochemical Activity physical 3109943 PDE6D Two-hybrid physical 11786539 RALA Two-hybrid physical 11786539 RHEB Affinity Capture-Western physical 15854902 RAF1 Affinity Capture-Western physical 16803888 RAF1 Two-hybrid physical 7862125 RIN1 Two-hybrid physical 7862125 RIN1 Reconstituted Complex physical 7862125 RAF1 Reconstituted Complex physical 7969158 MAP2K1 Affinity Capture-Western physical 7969158 DGKZ Affinity Capture-Western physical 11257115 RALGDS Two-hybrid physical 7972015 RALGDS Reconstituted Complex physical 7972015 IKZF3 Two-hybrid physical 10369681 RAF1 Two-hybrid physical 10369681 IKZF3 Affinity Capture-Western physical 10369681 IKZF3 Reconstituted Complex physical 10369681 RAP1GDS1 Reconstituted Complex physical 11948427 RAP1GDS1 Affinity Capture-Western physical 11948427 RALGDS Two-hybrid physical 9038168 RGL2 Two-hybrid physical 8939933 RGL2 Reconstituted Complex physical 8939933 MLLT4 Reconstituted Complex physical 10334923 MLLT4 Affinity Capture-Western physical 10334923 RAF1 Two-hybrid physical 8628317 NF1 Two-hybrid physical 8628317 RAF1 Reconstituted Complex physical 8530446 RAF1 Affinity Capture-Western physical 8530446 PIK3CA Reconstituted Complex physical 8665852 RALGDS Two-hybrid physical 7809086 RALGDS Reconstituted Complex physical 7809086 PIK3R1 Affinity Capture-Western physical 10212255 RALGDS Reconstituted Complex physical 9150145 RAF1 Reconstituted Complex physical 9150145 PIK3R1 Reconstituted Complex physical 9150145 PLAU Phenotypic Suppression genetic 10402467 RAF1 Affinity Capture-Western physical 12379659 ERBB2IP Affinity Capture-Western physical 12379659 PIK3CG Co-crystal Structure physical 11136978 RASA1 Reconstituted Complex physical 7628625 RASA1 Co-crystal Structure physical 9219684 RASA1 Biochemical Activity physical 11389730 LGALS1 Affinity Capture-MS physical 11709720 LGALS1 Affinity Capture-Western physical 11709720 SNRPE Two-hybrid physical 9154803 RALGDS Two-hybrid physical 9154803 RAF1 Reconstituted Complex physical 9154803 ZHX2 Two-hybrid physical 17533377 RGL2 Two-hybrid physical 20936779 RALGDS Two-hybrid physical 20936779 RGL1 Two-hybrid physical 20936779 DEAF1 Two-hybrid physical 21900206 ZHX2 Reconstituted Complex physical 11205744