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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for BIRC5 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000086 G2/M transition of mitotic cell cycle IDA GO:0000087 M phase of mitotic cell cycle TAS GO:0000236 mitotic prometaphase TAS GO:0000278 mitotic cell cycle TAS GO:0000910 cytokinesis IMP GO:0006915 apoptosis IEA GO:0006916 anti-apoptosis IDA GO:0007059 chromosome segregation IEA GO:0007067 mitosis TAS GO:0031503 protein complex localization IMP GO:0031536 positive regulation of exit from mitosis IMP GO:0031577 spindle checkpoint IMP GO:0043154 negative regulation of caspase activity IDA GO:0043154 negative regulation of caspase activity IMP GO:0045931 positive regulation of mitotic cell cycle IMP GO:0051301 cell division IEA GO:0051301 cell division IMP GO:0051303 establishment of chromosome localization IMP cellular_component GO:0000228 nuclear chromosome IDA GO:0000775 chromosome, centromeric region IDA GO:0005622 intracellular IEA GO:0005634 nucleus IDA GO:0005730 nucleolus IDA GO:0005737 cytoplasm IDA GO:0005814 centriole IDA GO:0005819 spindle IEA GO:0005829 cytosol IDA GO:0005829 cytosol TAS GO:0005856 cytoskeleton IEA GO:0005876 spindle microtubule IDA GO:0005881 cytoplasmic microtubule IDA GO:0030496 midbody IDA GO:0031021 interphase microtubule organizing center IDA GO:0032133 chromosome passenger complex IPI molecular_function GO:0004869 cysteine-type endopeptidase inhibitor activity IEA GO:0005515 protein binding IPI GO:0008017 microtubule binding IDA GO:0008270 zinc ion binding IDA GO:0008270 zinc ion binding NAS GO:0008536 Ran GTPase binding IPI GO:0015631 tubulin binding IDA GO:0019899 enzyme binding IPI GO:0030414 peptidase inhibitor activity IEA GO:0042802 identical protein binding IPI GO:0042803 protein homodimerization activity IDA GO:0042803 protein homodimerization activity IPI GO:0043027 caspase inhibitor activity IMP GO:0046872 metal ion binding IEA GO:0046982 protein heterodimerization activity IDA GO:0048037 cofactor binding IDA GO:0050897 cobalt ion binding NAS GO:0051087 chaperone binding IPI

Protein-protein interaction details for BIRC5 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID AURKB Two-hybrid physical 11516652 USF2 Affinity Capture-MS physical 17353931 CDCA8 Affinity Capture-Western physical 15260989 CDCA8 Affinity Capture-Western physical 15249581 CDCA8 Reconstituted Complex physical 15249581 DIABLO Affinity Capture-Western physical 12660240 DIABLO Reconstituted Complex physical 12660240 AURKB Reconstituted Complex physical 12419797 AURKB Phenotypic Enhancement genetic 12419797 INCENP Reconstituted Complex physical 11516652 AURKB Reconstituted Complex physical 11516652 INCENP Co-localization physical 11516652 BIRC5 Co-crystal Structure physical 10876248 BIRC5 Co-crystal Structure physical 10949039 CASP7 Reconstituted Complex physical 9850056 CASP3 Reconstituted Complex physical 9850056 CDK2 Affinity Capture-Western physical 11069302 CASP9 Affinity Capture-Western physical 11069302 BIRC5 Reconstituted Complex physical 11170436 CASP7 Biochemical Activity physical 11170436 CASP3 Biochemical Activity physical 11170436 CASP3 Reconstituted Complex physical 11170436 CASP7 Reconstituted Complex physical 11170436 CDK4 Affinity Capture-Western physical 10713676 XIAP Affinity Capture-Western physical 17613533 INCENP Affinity Capture-Western physical 19951914 AURKB Co-localization physical 19951914 DIABLO Affinity Capture-Western physical 15541727 EVI5 Affinity Capture-Western physical 16764853 EVI5 Reconstituted Complex physical 16764853 XIAP Affinity Capture-Western physical 15218035 XIAP Reconstituted Complex physical 15218035 BIRC2 Reconstituted Complex physical 15218035 BIRC3 Reconstituted Complex physical 15218035 KCNJ6 Reconstituted Complex physical 15218035 USP9X Affinity Capture-Western physical 16322459 UFD1L Affinity Capture-Western physical 16322459 UFD1L Affinity Capture-Western physical 16322459 PRKDC Affinity Capture-Western physical 20394854 MDC1 Affinity Capture-Western physical 20394854 XRCC6 Affinity Capture-Western physical 20394854 H2AFX Affinity Capture-Western physical 20394854 MDC1 Affinity Capture-Western physical 20394854 PRKDC Affinity Capture-Western physical 20394854 AURKB Affinity Capture-Western physical 19995937 UBC Affinity Capture-Western physical 20856855 INCENP Affinity Capture-Western physical 16239925 XPO1 Reconstituted Complex physical 17099693 XPO1 Affinity Capture-Western physical 17099693 AURKB Affinity Capture-Western physical 17099693 INCENP Affinity Capture-Western physical 17099693 CDCA8 Affinity Capture-Western physical 17099693 CDCA8 Affinity Capture-Western physical 17099693 BIRC5 Reconstituted Complex physical 17099693 AURKB Reconstituted Complex physical 17099693 INCENP Reconstituted Complex physical 17099693 CDCA8 Reconstituted Complex physical 17099693 AURKB Reconstituted Complex physical 21554500