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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for INS (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000165 MAPKKK cascade IDA GO:0002674 negative regulation of acute inflammatory response IDA GO:0005975 carbohydrate metabolic process IEA GO:0006006 glucose metabolic process IEA GO:0006112 energy reserve metabolic process TAS GO:0006355 regulation of transcription, DNA-dependent NAS GO:0006521 regulation of cellular amino acid metabolic process IMP GO:0006953 acute-phase response IDA GO:0007186 G-protein coupled receptor protein signaling pathway IDA GO:0007267 cell-cell signaling IC GO:0008284 positive regulation of cell proliferation IDA GO:0008286 insulin receptor signaling pathway TAS GO:0008543 fibroblast growth factor receptor signaling pathway TAS GO:0014068 positive regulation of phosphatidylinositol 3-kinase cascade IDA GO:0015758 glucose transport IDA GO:0022898 regulation of transmembrane transporter activity IDA GO:0030307 positive regulation of cell growth NAS GO:0030335 positive regulation of cell migration ISS GO:0031018 endocrine pancreas development TAS GO:0031954 positive regulation of protein autophosphorylation ISS GO:0032148 activation of protein kinase B activity IDA GO:0032270 positive regulation of cellular protein metabolic process IMP GO:0032880 regulation of protein localization IDA GO:0033861 negative regulation of NAD(P)H oxidase activity IDA GO:0042060 wound healing IDA GO:0042177 negative regulation of protein catabolic process IDA GO:0042593 glucose homeostasis IMP GO:0043066 negative regulation of apoptosis NAS GO:0043410 positive regulation of MAPKKK cascade IDA GO:0045429 positive regulation of nitric oxide biosynthetic process NAS GO:0045597 positive regulation of cell differentiation NAS GO:0045721 negative regulation of gluconeogenesis NAS GO:0045725 positive regulation of glycogen biosynthetic process IDA GO:0045740 positive regulation of DNA replication IDA GO:0045818 negative regulation of glycogen catabolic process IMP GO:0045821 positive regulation of glycolysis IDA GO:0045821 positive regulation of glycolysis IMP GO:0045840 positive regulation of mitosis IDA GO:0045861 negative regulation of proteolysis IMP GO:0045908 negative regulation of vasodilation NAS GO:0045909 positive regulation of vasodilation NAS GO:0045922 negative regulation of fatty acid metabolic process IMP GO:0046326 positive regulation of glucose import IDA GO:0046628 positive regulation of insulin receptor signaling pathway IDA GO:0046631 alpha-beta T cell activation IDA GO:0046889 positive regulation of lipid biosynthetic process NAS GO:0050708 regulation of protein secretion IDA GO:0050709 negative regulation of protein secretion IDA GO:0050715 positive regulation of cytokine secretion IDA GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA GO:0050796 regulation of insulin secretion TAS GO:0050995 negative regulation of lipid catabolic process NAS GO:0051000 positive regulation of nitric-oxide synthase activity NAS GO:0051092 positive regulation of NF-kappaB transcription factor activity IDA GO:0051897 positive regulation of protein kinase B signaling cascade IDA GO:0055089 fatty acid homeostasis IMP GO:0060266 negative regulation of respiratory burst involved in inflammatory response IDA GO:0060267 positive regulation of respiratory burst IDA GO:2000252 negative regulation of feeding behavior IDA cellular_component GO:0005576 extracellular region IC GO:0005576 extracellular region IEA GO:0005576 extracellular region TAS GO:0005615 extracellular space IDA GO:0005788 endoplasmic reticulum lumen TAS GO:0005796 Golgi lumen TAS GO:0030141 stored secretory granule TAS GO:0031904 endosome lumen TAS molecular_function GO:0005158 insulin receptor binding IDA GO:0005158 insulin receptor binding IPI GO:0005159 insulin-like growth factor receptor binding IPI GO:0005179 hormone activity IC GO:0005179 hormone activity IEA GO:0005179 hormone activity IMP GO:0005179 hormone activity NAS GO:0005515 protein binding IPI

Protein-protein interaction details for INS (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID TXNDC17 Biochemical Activity physical 14607844 MLL Biochemical Activity physical 14607844 NOV Reconstituted Complex physical 10084601 IGFBP7 Reconstituted Complex physical 9388210 MAPK6 Two-hybrid physical 21900206