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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for IRAK2 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000187 activation of MAPK activity TAS GO:0001959 regulation of cytokine-mediated signaling pathway IMP GO:0002218 activation of innate immune response TAS GO:0002224 toll-like receptor signaling pathway TAS GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS GO:0006468 protein phosphorylation TAS GO:0006954 inflammatory response TAS GO:0007165 signal transduction IEA GO:0007249 I-kappaB kinase/NF-kappaB cascade TAS GO:0007254 JNK cascade TAS GO:0008063 Toll signaling pathway TAS GO:0031663 lipopolysaccharide-mediated signaling pathway IEA GO:0032088 negative regulation of NF-kappaB transcription factor activity IMP GO:0034130 toll-like receptor 1 signaling pathway TAS GO:0034134 toll-like receptor 2 signaling pathway TAS GO:0034138 toll-like receptor 3 signaling pathway TAS GO:0034142 toll-like receptor 4 signaling pathway TAS GO:0045087 innate immune response TAS GO:0051092 positive regulation of NF-kappaB transcription factor activity IMP GO:0051092 positive regulation of NF-kappaB transcription factor activity TAS GO:0051403 stress-activated MAPK cascade TAS GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway TAS GO:0070498 interleukin-1-mediated signaling pathway IMP GO:0070555 response to interleukin-1 IMP cellular_component GO:0005829 cytosol TAS GO:0005886 plasma membrane TAS GO:0009986 cell surface IDA GO:0010008 endosome membrane TAS molecular_function GO:0000166 nucleotide binding IEA GO:0004672 protein kinase activity IEA GO:0004704 NF-kappaB-inducing kinase activity TAS GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0016772 transferase activity, transferring phosphorus-containing groups IEA GO:0042803 protein homodimerization activity IPI GO:0046982 protein heterodimerization activity IPI

Protein-protein interaction details for IRAK2 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID MYD88 Affinity Capture-Western physical 10383454 TRAF6 Affinity Capture-Western physical 10383454 TIRAP Phenotypic Suppression genetic 11544529 MYD88 Phenotypic Suppression genetic 11544529 TIRAP Affinity Capture-Western physical 11544529 TIRAP Affinity Capture-Western physical 11544529 IL1R1 Affinity Capture-Western physical 9374458 TRAF6 Affinity Capture-Western physical 9374458 MYD88 Affinity Capture-Western physical 9374458 TRAF6 Affinity Capture-Western physical 17878161 TLR3 Affinity Capture-Western physical 17878161 PELI1 Affinity Capture-Western physical 17675297 PELI2 Affinity Capture-Western physical 17675297 PELI3 Affinity Capture-Western physical 17675297 MME Affinity Capture-MS physical 17342744 TNFAIP3 Affinity Capture-Western physical 21220427 IRAK1 Affinity Capture-MS physical 21903422 IQSEC1 Affinity Capture-MS physical 21903422 YTHDF1 Affinity Capture-MS physical 21903422 ZC3H12C Affinity Capture-MS physical 21903422 ARAF Affinity Capture-MS physical 21903422 BAG3 Affinity Capture-MS physical 21903422 CABC1 Affinity Capture-MS physical 21903422 CDC37 Affinity Capture-MS physical 21903422 FASTKD5 Affinity Capture-MS physical 21903422 IQCB1 Affinity Capture-MS physical 21903422 IRAK1 Affinity Capture-MS physical 21903422 SESTD1 Affinity Capture-MS physical 21903422 SNRNP200 Affinity Capture-MS physical 21903422 STT3A Affinity Capture-MS physical 21903422 TARDBP Affinity Capture-MS physical 21903422 TRAF6 Affinity Capture-MS physical 21903422 ZC3H12A Affinity Capture-MS physical 21903422 IRAK3 Affinity Capture-MS physical 21903422 IRAK4 Affinity Capture-MS physical 21903422 TIRAP Affinity Capture-MS physical 21903422 SARM1 Affinity Capture-MS physical 21903422 TOLLIP Affinity Capture-MS physical 21903422 TRAF6 Affinity Capture-MS physical 21903422 ARAF Reconstituted Complex physical 21903422 STT3A Reconstituted Complex physical 21903422 TARDBP Reconstituted Complex physical 21903422 ZC3H12A Reconstituted Complex physical 21903422 SARM1 Reconstituted Complex physical 21903422 TOLLIP Reconstituted Complex physical 21903422 UBC Affinity Capture-MS physical 21987572