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Gene
Protein
Transcript
Promoter
Expression
GO/PPI
PubMed
Cross reference
Gene Ontology information for IRS1 (
Homo sapiens
)
(Information is obtained from AmiGO)
ID
Term
Evidence
biological_process
GO:0002053
positive regulation of mesenchymal cell proliferation
IEA
GO:0007165
signal transduction
TAS
GO:0007169
transmembrane receptor protein tyrosine kinase signaling pathway
ISS
GO:0008284
positive regulation of cell proliferation
NAS
GO:0008286
insulin receptor signaling pathway
IDA
GO:0008286
insulin receptor signaling pathway
IMP
GO:0008286
insulin receptor signaling pathway
IPI
GO:0008286
insulin receptor signaling pathway
TAS
GO:0008543
fibroblast growth factor receptor signaling pathway
TAS
GO:0010468
regulation of gene expression
IEA
GO:0010907
positive regulation of glucose metabolic process
IMP
GO:0014065
phosphatidylinositol 3-kinase cascade
IDA
GO:0016042
lipid catabolic process
IEA
GO:0030335
positive regulation of cell migration
IEA
GO:0030879
mammary gland development
IEA
GO:0032000
positive regulation of fatty acid beta-oxidation
IMP
GO:0032868
response to insulin stimulus
IDA
GO:0032869
cellular response to insulin stimulus
IMP
GO:0034504
protein localization to nucleus
IEA
GO:0042327
positive regulation of phosphorylation
IEA
GO:0042593
glucose homeostasis
TAS
GO:0043434
response to peptide hormone stimulus
ISS
GO:0043552
positive regulation of phosphatidylinositol 3-kinase activity
ISS
GO:0045725
positive regulation of glycogen biosynthetic process
IMP
GO:0045725
positive regulation of glycogen biosynthetic process
NAS
GO:0046326
positive regulation of glucose import
IMP
GO:0046627
negative regulation of insulin receptor signaling pathway
ISS
GO:0046628
positive regulation of insulin receptor signaling pathway
ISS
GO:0046676
negative regulation of insulin secretion
IDA
GO:0048009
insulin-like growth factor receptor signaling pathway
IPI
GO:0048011
nerve growth factor receptor signaling pathway
TAS
GO:0048015
phosphatidylinositol-mediated signaling
TAS
GO:0051291
protein heterooligomerization
IEA
GO:0070094
positive regulation of glucagon secretion
IEA
GO:0090275
negative regulation of somatostatin secretion
IEA
cellular_component
GO:0005634
nucleus
ISS
GO:0005737
cytoplasm
ISS
GO:0005792
microsome
ISS
GO:0005829
cytosol
TAS
GO:0005886
plasma membrane
TAS
GO:0005899
insulin receptor complex
ISS
GO:0005901
caveola
IDA
molecular_function
GO:0004871
signal transducer activity
IEA
GO:0005010
insulin-like growth factor-activated receptor activity
IEA
GO:0005068
transmembrane receptor protein tyrosine kinase adaptor activity
ISS
GO:0005080
protein kinase C binding
ISS
GO:0005158
insulin receptor binding
IPI
GO:0005159
insulin-like growth factor receptor binding
IPI
GO:0005515
protein binding
IPI
GO:0042169
SH2 domain binding
ISS
GO:0043548
phosphatidylinositol 3-kinase binding
IPI
GO:0043548
phosphatidylinositol 3-kinase binding
ISS
GO:0046934
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
TAS
Protein-protein interaction details for IRS1 (
Homo sapiens
)
(Information is obtained from BioGRID)
Interacting human protein
Experiment
Type
PubMed ID
IGF1R
Two-hybrid
physical
7559507
PTK2
Two-hybrid
physical
9822703
MAPK8
Two-hybrid
physical
11606564
INSR
Two-hybrid
physical
11606564
SFN
Affinity Capture-MS
physical
15778465
SOCS1
Affinity Capture-Western
physical
12228220
PIK3R3
Affinity Capture-Western
physical
10417350
INSR
Two-hybrid
physical
8626379
PIK3R1
Affinity Capture-Western
physical
1381348
GRB2
Affinity Capture-Western
physical
8491186
GRB2
Affinity Capture-Western
physical
8491186
GRB2
Reconstituted Complex
physical
8491186
JAK1
Biochemical Activity
physical
9492017
JAK2
Biochemical Activity
physical
9492017
KHDRBS1
Affinity Capture-Western
physical
11604231
PTPN1
Reconstituted Complex
physical
10660596
PIK3R3
Affinity Capture-Western
physical
9415396
GRB10
Reconstituted Complex
physical
8621530
PIK3R1
Affinity Capture-Western
physical
12173038
GRB2
Affinity Capture-Western
physical
12173038
CHUK
Affinity Capture-Western
physical
12351658
IKBKB
Affinity Capture-Western
physical
12351658
IGF1R
Two-hybrid
physical
8776723
IGF1R
Two-hybrid
physical
8776723
YWHAE
Reconstituted Complex
physical
9111084
YWHAE
Two-hybrid
physical
9111084
PTPN11
Reconstituted Complex
physical
8505282
BCL2
Affinity Capture-Western
physical
10679027
BCL2
Affinity Capture-Western
physical
10679027
BCL2L1
Affinity Capture-Western
physical
10679027
MTOR
Affinity Capture-Western
physical
11287630
PIK3CA
Affinity Capture-Western
physical
16354680
PIK3R1
Affinity Capture-Western
physical
12730242
JAK3
Affinity Capture-Western
physical
7499365
JAK1
Affinity Capture-Western
physical
7499365
AP3S1
Reconstituted Complex
physical
9792713
PTPN11
Affinity Capture-Western
physical
9756938
IGF1R
Affinity Capture-Western
physical
10082579
MAPK8
Affinity Capture-Western
physical
10722755
MAPK8
Reconstituted Complex
physical
10722755
PTPN1
Affinity Capture-Western
physical
11579209
SHC1
Reconstituted Complex
physical
7499194
YWHAH
Affinity Capture-Western
physical
11969417
JAK2
Affinity Capture-Western
physical
11208867
PRKCD
Affinity Capture-Western
physical
12031982
NISCH
Affinity Capture-Western
physical
11912194
YWHAB
Reconstituted Complex
physical
9422753
PIK3R1
Far Western
physical
12107746
GRB2
Reconstituted Complex
physical
8536716
NCK2
Reconstituted Complex
physical
9843575
AKT1
Affinity Capture-Western
physical
10497255
IRS2
Co-fractionation
physical
12554758
UBTF
Affinity Capture-Western
physical
12554758
PTK2
Affinity Capture-Western
physical
9822703
ALK
Affinity Capture-Western
physical
14968112
CBLB
Affinity Capture-Western
physical
16734387
HDAC2
Two-hybrid
physical
15522123
HDAC2
Reconstituted Complex
physical
15522123
HDAC2
Affinity Capture-Western
physical
15522123
UBC
Affinity Capture-Western
physical
15516986
PRKCD
Biochemical Activity
physical
15516986
UBC
Affinity Capture-Western
physical
12821935
ESR1
Affinity Capture-Western
physical
12821935
ESR1
Affinity Capture-Western
physical
12821935
UBTF
Affinity Capture-Western
physical
17332342
UBC
Affinity Capture-Western
physical
20663861