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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for MRE11A (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000019 regulation of mitotic recombination TAS GO:0000075 cell cycle checkpoint IEA GO:0000724 double-strand break repair via homologous recombination TAS GO:0006259 DNA metabolic process IEA GO:0006281 DNA repair TAS GO:0006302 double-strand break repair IEA GO:0006302 double-strand break repair TAS GO:0006303 double-strand break repair via nonhomologous end joining TAS GO:0006310 DNA recombination TAS GO:0006974 response to DNA damage stimulus IEA GO:0007004 telomere maintenance via telomerase TAS GO:0007062 sister chromatid cohesion IMP GO:0007126 meiosis IEA GO:0007129 synapsis IEA GO:0007131 reciprocal meiotic recombination TAS GO:0007507 heart development IEA GO:0008283 cell proliferation IEA GO:0031954 positive regulation of protein autophosphorylation IDA GO:0032508 DNA duplex unwinding IMP GO:0032876 negative regulation of DNA endoreduplication IMP GO:0033674 positive regulation of kinase activity IDA GO:0051276 chromosome organization IEA cellular_component GO:0000781 chromosome, telomeric region IDA GO:0000790 nuclear chromatin IEA GO:0000794 condensed nuclear chromosome IEA GO:0005634 nucleus IDA GO:0005634 nucleus IEA GO:0005654 nucleoplasm IEA GO:0005654 nucleoplasm TAS GO:0005730 nucleolus IDA GO:0030870 Mre11 complex IDA GO:0030870 Mre11 complex NAS GO:0048471 perinuclear region of cytoplasm IEA molecular_function GO:0000014 single-stranded DNA specific endodeoxyribonuclease activity TAS GO:0003677 DNA binding IDA GO:0003690 double-stranded DNA binding TAS GO:0004003 ATP-dependent DNA helicase activity IMP GO:0004518 nuclease activity TAS GO:0004519 endonuclease activity IEA GO:0004520 endodeoxyribonuclease activity TAS GO:0004527 exonuclease activity IEA GO:0005515 protein binding IPI GO:0008022 protein C-terminus binding IPI GO:0008408 3'-5' exonuclease activity TAS GO:0016787 hydrolase activity IEA GO:0030145 manganese ion binding IEA

Protein-protein interaction details for MRE11A (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID XRCC6 Two-hybrid physical 10508516 BLM Co-purification physical 10783165 BRCA1 Co-purification physical 10783165 NBN Co-purification physical 10783165 RAD50 Co-purification physical 10783165 BRCA1 Reconstituted Complex physical 11353843 BRCA1 Co-purification physical 11504724 BRCA1 Affinity Capture-Western physical 11504724 RAD50 Co-purification physical 11504724 RAD50 Affinity Capture-Western physical 11504724 RAD50 Affinity Capture-Western physical 11504724 NBN Affinity Capture-Western physical 12679336 ATM Protein-peptide physical 10608806 ATR Protein-peptide physical 10608806 PRKDC Protein-peptide physical 10608806 ATM Co-purification physical 10783165 MLH1 Co-purification physical 10783165 BRCA1 Co-localization physical 10426999 MSH2 Co-purification physical 10783165 MSH6 Co-purification physical 10783165 RFC1 Co-purification physical 10783165 TERF2IP Affinity Capture-MS physical 15100233 MDC1 Affinity Capture-MS physical 14519663 MDC1 Affinity Capture-Western physical 14519663 RAD50 Affinity Capture-Western physical 8756642 RAD50 Affinity Capture-Western physical 8756642 RAD50 Co-purification physical 9705271 NBN Co-purification physical 9705271 NBN Two-hybrid physical 18458108 NBN Two-hybrid physical 11238951 NBN Affinity Capture-Western physical 11238951 NBN Co-localization physical 11238951 TERF2 Affinity Capture-Western physical 10888888 TERF2 Affinity Capture-Western physical 10888888 XRCC6 Reconstituted Complex physical 10508516 XRCC6 Affinity Capture-Western physical 10508516 RAD50 Affinity Capture-Western physical 10508516 LIG1 Two-hybrid physical 8530104 RECQL5 Affinity Capture-MS physical 19270065 RECQL5 Affinity Capture-Western physical 19270065 RAD50 Affinity Capture-Western physical 19270065 NBN Affinity Capture-Western physical 19270065 RECQL5 Affinity Capture-Western physical 19270065 RECQL5 Reconstituted Complex physical 19270065 TERF2 Affinity Capture-Western physical 18212065 USP11 Affinity Capture-MS physical 19615732 DDX1 Affinity Capture-Western physical 18710941 SUMO2 Affinity Capture-MS physical 19394292 MDC1 Affinity Capture-MS physical 12607003 RAD50 Affinity Capture-MS physical 12607003 NBN Affinity Capture-MS physical 12607003 MDC1 Affinity Capture-Western physical 12607003 RAD50 Affinity Capture-Western physical 12607003 NBN Affinity Capture-Western physical 12607003 RAD50 Affinity Capture-Western physical 12607003 MDC1 Affinity Capture-Western physical 12607003 NBN Affinity Capture-Western physical 12607003 MDC1 Reconstituted Complex physical 12607003 ATF2 Co-localization physical 15916964 PRMT1 Affinity Capture-Western physical 18285453 NLRP2 Affinity Capture-Western physical 18285453 H2AFX Affinity Capture-Western physical 15201865 PAXIP1 Affinity Capture-MS physical 17500065 PAXIP1 Affinity Capture-Western physical 17500065 RAD50 Affinity Capture-Western physical 17500065 NBN Affinity Capture-Western physical 17500065 RAD50 Affinity Capture-Western physical 17500065 DCLRE1B Affinity Capture-Western physical 18469862 KAT5 Affinity Capture-Western physical 20070254 NBN Affinity Capture-Western physical 12447395 UBC Affinity Capture-MS physical 16196087 EP300 Affinity Capture-MS physical 16051665 NBN Co-fractionation physical 19244116 NBN Affinity Capture-Western physical 19244116 TERF2IP Affinity Capture-MS physical 15383534 BARD1 Affinity Capture-Western physical 16391231 BRCA1 Affinity Capture-Western physical 16391231 RAD50 Affinity Capture-Western physical 16391231 BACH1 Affinity Capture-Western physical 16391231 NBN Affinity Capture-Western physical 21884979 UBC Affinity Capture-MS physical 18781797