Home

Search

Browse

RAGs

User guide

FAQs

Links

Questions

Contribute

Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for NOTCH1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS GO:0001701 in utero embryonic development IEA GO:0001708 cell fate specification IEA GO:0001889 liver development IEA GO:0002040 sprouting angiogenesis IEA GO:0002052 positive regulation of neuroblast proliferation IEA GO:0003180 aortic valve morphogenesis IMP GO:0003264 regulation of cardioblast proliferation IEA GO:0006355 regulation of transcription, DNA-dependent TAS GO:0006955 immune response NAS GO:0007219 Notch signaling pathway IMP GO:0007219 Notch signaling pathway TAS GO:0007220 Notch receptor processing TAS GO:0007221 positive regulation of transcription of Notch receptor target IEA GO:0007283 spermatogenesis IEA GO:0007368 determination of left/right symmetry IEA GO:0007386 compartment pattern specification IEA GO:0007409 axonogenesis IEA GO:0007440 foregut morphogenesis IEA GO:0007492 endoderm development IEA GO:0007507 heart development IMP GO:0008284 positive regulation of cell proliferation IDA GO:0009790 embryo development IEA GO:0010467 gene expression TAS GO:0010718 positive regulation of epithelial to mesenchymal transition IMP GO:0010812 negative regulation of cell-substrate adhesion IDA GO:0014807 regulation of somitogenesis IEA GO:0021515 cell differentiation in spinal cord IEA GO:0021915 neural tube development IEA GO:0030324 lung development IEA GO:0030513 positive regulation of BMP signaling pathway ISS GO:0030514 negative regulation of BMP signaling pathway ISS GO:0030900 forebrain development IEA GO:0031069 hair follicle morphogenesis IEA GO:0031100 organ regeneration IEA GO:0031960 response to corticosteroid stimulus IEA GO:0032496 response to lipopolysaccharide IEA GO:0035116 embryonic hindlimb morphogenesis IEA GO:0042246 tissue regeneration IEA GO:0042640 anagen IEA GO:0043065 positive regulation of apoptosis IEA GO:0043066 negative regulation of apoptosis IEA GO:0045603 positive regulation of endothelial cell differentiation IEA GO:0045618 positive regulation of keratinocyte differentiation IEA GO:0045662 negative regulation of myoblast differentiation IMP GO:0045668 negative regulation of osteoblast differentiation ISS GO:0045892 negative regulation of transcription, DNA-dependent ISS GO:0045893 positive regulation of transcription, DNA-dependent ISS GO:0045955 negative regulation of calcium ion-dependent exocytosis IEA GO:0046427 positive regulation of JAK-STAT cascade ISS GO:0046533 negative regulation of photoreceptor cell differentiation IEA GO:0048103 somatic stem cell division IEA GO:0048663 neuron fate commitment IEA GO:0048711 positive regulation of astrocyte differentiation ISS GO:0048715 negative regulation of oligodendrocyte differentiation ISS GO:0048754 branching morphogenesis of a tube IEA GO:0050679 positive regulation of epithelial cell proliferation IEA GO:0050767 regulation of neurogenesis IEA GO:0050793 regulation of developmental process IEA GO:0060253 negative regulation of glial cell proliferation ISS GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development IEA GO:0060548 negative regulation of cell death IEA GO:0060740 prostate gland epithelium morphogenesis IEA GO:0060768 regulation of epithelial cell proliferation involved in prostate gland development IEA GO:0097150 neuronal stem cell maintenance IEP GO:2000737 negative regulation of stem cell differentiation IMP GO:2000974 negative regulation of pro-B cell differentiation ISS cellular_component GO:0001669 acrosomal vesicle IEA GO:0002193 MAML1-RBP-Jkappa- ICN1 complex IDA GO:0005576 extracellular region TAS GO:0005634 nucleus TAS GO:0005654 nucleoplasm TAS GO:0005737 cytoplasm IEA GO:0005788 endoplasmic reticulum lumen TAS GO:0005794 Golgi apparatus IEA GO:0005796 Golgi lumen TAS GO:0005829 cytosol TAS GO:0005886 plasma membrane TAS GO:0016021 integral to membrane NAS molecular_function GO:0001047 core promoter binding ISS GO:0003700 sequence-specific DNA binding transcription factor activity IEA GO:0004872 receptor activity IEA GO:0005509 calcium ion binding IEA GO:0005515 protein binding IPI GO:0031490 chromatin DNA binding IEA GO:0043565 sequence-specific DNA binding IEA

Protein-protein interaction details for NOTCH1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID SMAD3 Reconstituted Complex physical 14638857 SMAD3 Affinity Capture-Western physical 14638857 LCK Affinity Capture-Western physical 14583609 LCK Affinity Capture-Western physical 14583609 PIK3CA Affinity Capture-Western physical 14583609 CNTN1 Affinity Capture-Western physical 14567914 YY1 Affinity Capture-Western physical 12913000 YY1 Affinity Capture-Western physical 12913000 YY1 Reconstituted Complex physical 12913000 RBPJ Reconstituted Complex physical 12644465 DTX1 Affinity Capture-Western physical 11564735 SNW1 Reconstituted Complex physical 11404076 SNW1 Two-hybrid physical 11404076 NOTCH3 Phenotypic Suppression genetic 11404076 XRCC6 Two-hybrid physical 16169070 RELA Affinity Capture-Western physical 8642313 NFKB1 Affinity Capture-Western physical 8642313 NFKB1 Reconstituted Complex physical 8642313 DLL1 Reconstituted Complex physical 11006133 JAG1 Reconstituted Complex physical 11006133 JAG2 Reconstituted Complex physical 11006133 LEF1 Reconstituted Complex physical 11604490 NUMB Reconstituted Complex physical 8755477 GSK3B Biochemical Activity physical 12123574 GSK3B Reconstituted Complex physical 12123574 NOTCH1 Affinity Capture-Western physical 10669757 NFKB1 Reconstituted Complex physical 11418662 MAML1 Reconstituted Complex physical 11101851 MAML1 Affinity Capture-Western physical 11101851 NOV Affinity Capture-Western physical 12050162 NOV Affinity Capture-Western physical 12050162 NOV Reconstituted Complex physical 12050162 PSEN1 Affinity Capture-Western physical 10077672 FBXW7 Affinity Capture-Western physical 11425854 MAML1 Two-hybrid physical 12370315 MAML2 Two-hybrid physical 12370315 MAML3 Two-hybrid physical 12370315 RBPJ Reconstituted Complex physical 9111040 RBPJ Affinity Capture-Western physical 9111040 SNW1 Affinity Capture-Western physical 10713164 UBC Affinity Capture-Western physical 18628966 UBC Affinity Capture-Western physical 18628966 FBXW7 Affinity Capture-Western physical 17646408 FBXW7 Affinity Capture-Western physical 17646408 UBC Affinity Capture-Western physical 17646408 UBC Affinity Capture-Western physical 17575125 EP300 Affinity Capture-Western physical 19838210 AKT1 Biochemical Activity physical 18440314 UBC Affinity Capture-Western physical 11777909 CBL Affinity Capture-Western physical 11777909 UBC Affinity Capture-Western physical 10940313 ITCH Affinity Capture-Western physical 10940313 ITCH Affinity Capture-Western physical 10940313 CTNNB1 Affinity Capture-Western physical 19000719 CTNNB1 Affinity Capture-Western physical 19000719 CTNNB1 Reconstituted Complex physical 19000719 UBC Affinity Capture-Western physical 19000719 DTX1 Affinity Capture-Western physical 20208568 UBC Affinity Capture-Western physical 20208568 JAG1 Co-localization physical 20720151 SNW1 Reconstituted Complex physical 15546612 CACNA1A Two-hybrid physical 21078624 UBC Reconstituted Complex physical 19850743 SNAI1 Affinity Capture-MS physical 22128911 SNAI1 Affinity Capture-Western physical 22128911 SNAI1 Affinity Capture-Western physical 22128911 SNAI1 Reconstituted Complex physical 22128911 MDM2 Affinity Capture-Western physical 22128911 MDM2 Affinity Capture-Western physical 22128911