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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for FOXP3 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA GO:0001782 B cell homeostasis IBA GO:0001816 cytokine production IEA GO:0002053 positive regulation of mesenchymal cell proliferation IRD GO:0002262 myeloid cell homeostasis IBA GO:0002456 T cell mediated immunity IEA GO:0002513 tolerance induction to self antigen IBA GO:0002637 regulation of immunoglobulin production IEA GO:0002669 positive regulation of T cell anergy IBA GO:0002677 negative regulation of chronic inflammatory response IBA GO:0002725 negative regulation of T cell cytokine production IDA GO:0002851 positive regulation of peripheral T cell tolerance induction IBA GO:0006338 chromatin remodeling NAS GO:0006351 transcription, DNA-dependent IDA GO:0006351 transcription, DNA-dependent NAS GO:0006355 regulation of transcription, DNA-dependent NAS GO:0007389 pattern specification process IBA GO:0007519 skeletal muscle tissue development IRD GO:0008285 negative regulation of cell proliferation IDA GO:0009615 response to virus IEP GO:0009790 embryo development IBA GO:0009791 post-embryonic development IBA GO:0021549 cerebellum development IBA GO:0021757 caudate nucleus development IRD GO:0021758 putamen development IRD GO:0021987 cerebral cortex development IRD GO:0031064 negative regulation of histone deacetylation IGI GO:0032088 negative regulation of NF-kappaB transcription factor activity IDA GO:0032689 negative regulation of interferon-gamma production IDA GO:0032693 negative regulation of interleukin-10 production IDA GO:0032703 negative regulation of interleukin-2 production IDA GO:0032713 negative regulation of interleukin-4 production IDA GO:0032714 negative regulation of interleukin-5 production IBA GO:0032715 negative regulation of interleukin-6 production IBA GO:0032720 negative regulation of tumor necrosis factor production IBA GO:0032792 negative regulation of CREB transcription factor activity IDA GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IBA GO:0032914 positive regulation of transforming growth factor beta1 production IBA GO:0033092 positive regulation of immature T cell proliferation in thymus IBA GO:0035066 positive regulation of histone acetylation IMP GO:0035067 negative regulation of histone acetylation IBA GO:0040007 growth IRD GO:0042036 negative regulation of cytokine biosynthetic process IDA GO:0042110 T cell activation IDA GO:0042130 negative regulation of T cell proliferation IDA GO:0042297 vocal learning IRD GO:0043010 camera-type eye development IRD GO:0043029 T cell homeostasis NAS GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity IDA GO:0045077 negative regulation of interferon-gamma biosynthetic process IBA GO:0045085 negative regulation of interleukin-2 biosynthetic process IMP GO:0045892 negative regulation of transcription, DNA-dependent IDA GO:0045893 positive regulation of transcription, DNA-dependent IDA GO:0045893 positive regulation of transcription, DNA-dependent IMP GO:0045893 positive regulation of transcription, DNA-dependent ISS GO:0045944 positive regulation of transcription from RNA polymerase II promoter IMP GO:0046007 negative regulation of activated T cell proliferation NAS GO:0048286 lung alveolus development IRD GO:0048294 negative regulation of isotype switching to IgE isotypes IBA GO:0048302 regulation of isotype switching to IgG isotypes IBA GO:0048745 smooth muscle tissue development IRD GO:0050710 negative regulation of cytokine secretion IDA GO:0050777 negative regulation of immune response IDA GO:0050852 T cell receptor signaling pathway IBA GO:0060013 righting reflex IRD GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis IRD cellular_component GO:0005622 intracellular IEA GO:0005634 nucleus IDA GO:0005634 nucleus NAS GO:0005667 transcription factor complex IBA GO:0005737 cytoplasm IBA GO:0005737 cytoplasm NAS GO:0043234 protein complex NAS molecular_function GO:0003682 chromatin binding IBA GO:0003690 double-stranded DNA binding IBA GO:0003700 sequence-specific DNA binding transcription factor activity IDA GO:0003700 sequence-specific DNA binding transcription factor activity IEA GO:0003700 sequence-specific DNA binding transcription factor activity NAS GO:0003705 sequence-specific distal enhancer binding RNA polymerase II transcription factor activity IBA GO:0003714 transcription corepressor activity IBA GO:0005515 protein binding IPI GO:0008270 zinc ion binding IEA GO:0008301 DNA bending activity IBA GO:0035035 histone acetyltransferase binding IPI GO:0042803 protein homodimerization activity IPI GO:0042826 histone deacetylase binding IPI GO:0043565 sequence-specific DNA binding IDA GO:0043565 sequence-specific DNA binding IEA GO:0046872 metal ion binding IEA GO:0046982 protein heterodimerization activity IBA GO:0051059 NF-kappaB binding NAS GO:0051525 NFAT protein binding IPI

Protein-protein interaction details for FOXP3 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID NFATC2 Co-localization physical 19564342 KAT5 Affinity Capture-Western physical 17360565 HDAC7 Affinity Capture-Western physical 17360565 HDAC9 Affinity Capture-Western physical 17360565 HDAC2 Co-localization physical 19276356 HDAC4 Co-localization physical 19276356 IKZF4 Affinity Capture-Western physical 19696312 IKZF4 Affinity Capture-Western physical 19696312 IKZF4 Reconstituted Complex physical 19696312 IKZF4 Reconstituted Complex physical 19696312 IKZF4 Two-hybrid physical 19696312 REL Affinity Capture-Luminescence physical 21490927 NFATC1 Affinity Capture-Luminescence physical 21490927