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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for PLCE1 (Homo sapiens)
(Information is obtained from AmiGO)
IDTermEvidence
biological_process
GO:0000187activation of MAPK activityIDA
GO:0001558regulation of cell growthTAS
GO:0006644phospholipid metabolic processIC
GO:0006651diacylglycerol biosynthetic processTAS
GO:0006940regulation of smooth muscle contractionTAS
GO:0007010cytoskeleton organizationNAS
GO:0007173epidermal growth factor receptor signaling pathwayNAS
GO:0007200activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messengerIDA
GO:0007204elevation of cytosolic calcium ion concentrationTAS
GO:0007205activation of protein kinase C activity by G-protein coupled receptor protein signaling pathwayNAS
GO:0007265Ras protein signal transductionTAS
GO:0007507heart developmentTAS
GO:0008277regulation of G-protein coupled receptor protein signaling pathwayIDA
GO:0008283cell proliferationNAS
GO:0016042lipid catabolic processIEA
GO:0019722calcium-mediated signalingNAS
GO:0019722calcium-mediated signalingTAS
GO:0032835glomerulus developmentIMP
GO:0045859regulation of protein kinase activityIDA
GO:0046578regulation of Ras protein signal transductionIDA
GO:0048016inositol phosphate-mediated signalingTAS
cellular_component
GO:0000139Golgi membraneIEA
GO:0005624membrane fractionIDA
GO:0005737cytoplasmIDA
GO:0005794Golgi apparatusIEA
GO:0005829cytosolIDA
GO:0005886plasma membraneIDA
molecular_function
GO:0004435phosphatidylinositol phospholipase C activityIDA
GO:0004629phospholipase C activityIDA
GO:0005057receptor signaling protein activityTAS
GO:0005085guanyl-nucleotide exchange factor activityTAS
GO:0005509calcium ion bindingIEA
GO:0005515protein bindingIPI
GO:0016787hydrolase activityIEA
GO:0017016Ras GTPase bindingTAS
GO:0019899enzyme bindingIPI

Protein-protein interaction details for PLCE1 (Homo sapiens)
(Information is obtained from BioGRID)
Interacting human proteinExperimentTypePubMed ID
NRASTwo-hybridphysical16169070
SIAH1Affinity Capture-Westernphysical17998205
SIAH2Affinity Capture-Westernphysical17998205
SIAH2Reconstituted Complexphysical17998205
SIAH2Affinity Capture-Westernphysical17998205
UBCAffinity Capture-Westernphysical17998205