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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for PLK1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000086 G2/M transition of mitotic cell cycle TAS GO:0000087 M phase of mitotic cell cycle TAS GO:0000088 mitotic prophase TAS GO:0000236 mitotic prometaphase IEA GO:0000236 mitotic prometaphase TAS GO:0000278 mitotic cell cycle TAS GO:0000910 cytokinesis TAS GO:0006468 protein phosphorylation IDA GO:0006468 protein phosphorylation NAS GO:0007067 mitosis IDA GO:0007091 mitotic metaphase/anaphase transition TAS GO:0007346 regulation of mitotic cell cycle IMP GO:0008283 cell proliferation TAS GO:0010800 positive regulation of peptidyl-threonine phosphorylation IMP GO:0016567 protein ubiquitination IDA GO:0018105 peptidyl-serine phosphorylation IDA GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS GO:0031572 G2/M transition DNA damage checkpoint IDA GO:0031648 protein destabilization IDA GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP GO:0040038 polar body extrusion after meiotic divisions IEA GO:0043393 regulation of protein binding IMP GO:0045736 negative regulation of cyclin-dependent protein kinase activity IMP GO:0045862 positive regulation of proteolysis IDA GO:0046677 response to antibiotic IEA GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS GO:0051443 positive regulation of ubiquitin-protein ligase activity IMP GO:0051726 regulation of cell cycle TAS GO:0071168 protein localization to chromatin IDA GO:0090007 regulation of mitotic anaphase IMP cellular_component GO:0000776 kinetochore IDA GO:0000777 condensed chromosome kinetochore IEA GO:0000922 spindle pole IDA GO:0000922 spindle pole IEA GO:0000942 condensed nuclear chromosome outer kinetochore IDA GO:0005634 nucleus IDA GO:0005634 nucleus IEA GO:0005654 nucleoplasm TAS GO:0005694 chromosome IEA GO:0005737 cytoplasm IEA GO:0005813 centrosome IDA GO:0005829 cytosol TAS GO:0005856 cytoskeleton IEA GO:0005876 spindle microtubule IDA GO:0030496 midbody IDA GO:0051233 spindle midzone IDA GO:0051233 spindle midzone IEA molecular_function GO:0000166 nucleotide binding IEA GO:0004672 protein kinase activity IDA GO:0004674 protein serine/threonine kinase activity IDA GO:0004674 protein serine/threonine kinase activity IEA GO:0004674 protein serine/threonine kinase activity IMP GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0010997 anaphase-promoting complex binding IPI GO:0019901 protein kinase binding IPI GO:0042801 polo kinase kinase activity IDA

Protein-protein interaction details for PLK1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID BRCA2 Affinity Capture-Western physical 14647413 BRCA2 Reconstituted Complex physical 12815053 NUDC Reconstituted Complex physical 12852857 NUDC Affinity Capture-Western physical 12852857 DCTN1 Affinity Capture-Western physical 12852857 NUDC Biochemical Activity physical 12852857 GET4 Two-hybrid physical 16169070 MAGED1 Two-hybrid physical 16169070 RECQL5 Two-hybrid physical 16169070 DNAJB9 Two-hybrid physical 16169070 CDC25C Biochemical Activity physical 11202906 PIN1 Affinity Capture-Western physical 9499405 PIN1 Far Western physical 9499405 PIN1 Affinity Capture-Western physical 9499405 TSC1 Affinity Capture-Western physical 16339216 TSC1 Affinity Capture-Western physical 16339216 TSC2 Affinity Capture-Western physical 16339216 CHEK2 Affinity Capture-Western physical 12493754 CHEK2 Affinity Capture-Western physical 12493754 CHEK2 Biochemical Activity physical 12493754 PSMA7 Affinity Capture-MS physical 11205743 PSMA5 Affinity Capture-MS physical 11205743 PSMA2 Affinity Capture-MS physical 11205743 PSMA6 Affinity Capture-MS physical 11205743 PSMB1 Affinity Capture-MS physical 11205743 PSMB3 Affinity Capture-MS physical 11205743 PSMA1 Affinity Capture-Western physical 11205743 PSMA3 Affinity Capture-Western physical 11205743 PSMA4 Affinity Capture-Western physical 11205743 PSMA7 Affinity Capture-Western physical 11205743 PSMA5 Affinity Capture-Western physical 11205743 PSMA6 Affinity Capture-Western physical 11205743 PSMB3 Affinity Capture-Western physical 11205743 PSMB5 Affinity Capture-Western physical 11205743 PSMB6 Affinity Capture-Western physical 11205743 PSMB7 Affinity Capture-Western physical 11205743 PSMA5 Affinity Capture-Western physical 11205743 PSMA3 Affinity Capture-Western physical 11205743 PSMA4 Affinity Capture-Western physical 11205743 PSMA4 Biochemical Activity physical 11205743 PSMA3 Biochemical Activity physical 11205743 PIN1 Affinity Capture-Western physical 10037602 C13orf34 Affinity Capture-Western physical 18378770 C13orf34 Affinity Capture-Western physical 18378770 SGOL1 Affinity Capture-Western physical 18331714 CYLD Affinity Capture-MS physical 17495026 CYLD Affinity Capture-Western physical 17495026 USP20 Affinity Capture-MS physical 19615732 C19orf62 Affinity Capture-MS physical 19615732 BTBD12 Affinity Capture-MS physical 19596235 GIYD2 Affinity Capture-MS physical 19596235 SPAG9 Affinity Capture-MS physical 19596235 BICD2 Affinity Capture-MS physical 19596235 ERCC6L Affinity Capture-MS physical 19596235 C13orf34 Affinity Capture-MS physical 19596235 C2orf44 Affinity Capture-MS physical 19596235 PPP6R2 Affinity Capture-MS physical 19596235 TMF1 Affinity Capture-MS physical 19596235 BICD1 Affinity Capture-MS physical 19596235 DCTPP1 Affinity Capture-MS physical 19596235 FABP3 Affinity Capture-MS physical 19596235 ANKRD44 Affinity Capture-MS physical 19596235 OSBPL6 Affinity Capture-MS physical 19596235 LPL Affinity Capture-MS physical 19596235 PTHLH Affinity Capture-MS physical 19596235 BTN1A1 Affinity Capture-MS physical 19596235 CEP97 Affinity Capture-MS physical 19596235 SRPX Affinity Capture-MS physical 19596235 ANKRD28 Affinity Capture-MS physical 19596235 ANKRD52 Affinity Capture-MS physical 19596235 C20orf94 Affinity Capture-MS physical 19596235 GTF3C3 Affinity Capture-MS physical 19596235 RGPD4 Affinity Capture-MS physical 19596235 BTBD12 Affinity Capture-MS physical 19596235 BTBD12 Affinity Capture-Western physical 19596235 ERCC4 Affinity Capture-Western physical 19596235 ERCC4 Affinity Capture-Western physical 19596235 CLSPN Affinity Capture-Western physical 16885022 CLSPN Affinity Capture-Western physical 16885021 STK3 Affinity Capture-MS physical 20562859 PIN1 Reconstituted Complex physical 16118204 PIN1 Biochemical Activity physical 16118204 AURKA Affinity Capture-Western physical 18773538 FBXO5 Affinity Capture-Western physical 15469984 CTBP1 Affinity Capture-Western physical 16481748 TANK Two-hybrid physical 20484576 TANK Affinity Capture-Western physical 20484576 TANK Affinity Capture-Western physical 20484576 IKBKG Affinity Capture-Western physical 20484576 IKBKG Affinity Capture-Western physical 20484576 CHFR Biochemical Activity physical 11807090 UBC Reconstituted Complex physical 11807090 TOPORS Biochemical Activity physical 19473992 CTNNB1 Affinity Capture-MS physical 21610149 CTNNB1 Affinity Capture-Western physical 21610149 RELA Reconstituted Complex physical 21610149 MYC Affinity Capture-MS physical 17314511 TNFSF11 Two-hybrid physical 21900206 MAPK6 Two-hybrid physical 21900206 ACTL6B Two-hybrid physical 21900206 CIC Two-hybrid physical 21900206 RXRA Two-hybrid physical 21900206 RNF126 Two-hybrid physical 21900206 LRP5L Two-hybrid physical 21900206 CCDC115 Two-hybrid physical 21900206 FBXL5 Two-hybrid physical 21900206 VRK3 Two-hybrid physical 21900206 EIF6 Two-hybrid physical 21900206 PPID Two-hybrid physical 21900206 LMO4 Two-hybrid physical 21900206 C9orf114 Two-hybrid physical 21900206 MPP2 Two-hybrid physical 21900206 ZNF71 Two-hybrid physical 21900206 GLB1 Two-hybrid physical 21900206 TP53BP2 Two-hybrid physical 21900206 C5orf25 Two-hybrid physical 21900206 BAT3 Two-hybrid physical 21900206 C6orf136 Two-hybrid physical 21900206 CPSF3L Two-hybrid physical 21900206 ITSN1 Two-hybrid physical 21900206 TUBA1A Affinity Capture-Western physical 10191277 TUBB3 Affinity Capture-Western physical 10191277 TUBG1 Affinity Capture-Western physical 10191277 TUBB3 Reconstituted Complex physical 10191277