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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for ATR (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000075 cell cycle checkpoint TAS GO:0000077 DNA damage checkpoint IDA GO:0006260 DNA replication TAS GO:0006281 DNA repair TAS GO:0006468 protein phosphorylation TAS GO:0006974 response to DNA damage stimulus TAS GO:0007049 cell cycle TAS GO:0007275 multicellular organismal development TAS GO:0008156 negative regulation of DNA replication IMP GO:0018105 peptidyl-serine phosphorylation IDA GO:0034644 cellular response to UV IMP GO:0043393 regulation of protein binding IEA GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator IMP GO:0046777 protein autophosphorylation IDA GO:0071480 cellular response to gamma radiation IDA GO:0090399 replicative senescence IMP cellular_component GO:0001741 XY body IEA GO:0005634 nucleus IEA GO:0005654 nucleoplasm TAS GO:0016605 PML body IEA molecular_function GO:0000166 nucleotide binding IEA GO:0003677 DNA binding IEA GO:0004672 protein kinase activity IDA GO:0004674 protein serine/threonine kinase activity IDA GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0032405 MutLalpha complex binding IDA GO:0032407 MutSalpha complex binding IDA

Protein-protein interaction details for ATR (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID BRCA1 Reconstituted Complex physical 11114888 TP53 Reconstituted Complex physical 15159397 ABL1 Protein-peptide physical 10608806 AP1B1 Protein-peptide physical 10608806 AP2A2 Protein-peptide physical 10608806 ARHGEF1 Protein-peptide physical 10608806 ATM Protein-peptide physical 10608806 ATR Protein-peptide physical 10608806 BRCA1 Protein-peptide physical 10608806 BRCA2 Protein-peptide physical 10608806 CHEK1 Protein-peptide physical 10608806 E4F1 Protein-peptide physical 10608806 LIG4 Protein-peptide physical 10608806 MRE11A Protein-peptide physical 10608806 NBN Protein-peptide physical 10608806 PA2G4 Protein-peptide physical 10608806 PIK3CA Protein-peptide physical 10608806 POLD1 Protein-peptide physical 10608806 PPP2R2A Protein-peptide physical 10608806 PTS Protein-peptide physical 10608806 RAD17 Protein-peptide physical 10608806 RPA1 Protein-peptide physical 10608806 TP53 Protein-peptide physical 10608806 WRN Protein-peptide physical 10608806 BRCA1 Reconstituted Complex physical 11016625 BRCA1 Reconstituted Complex physical 11278964 BRCA1 Affinity Capture-Western physical 11278964 MCM7 Affinity Capture-Western physical 15210935 MCM2 Biochemical Activity physical 15210935 MSH2 Affinity Capture-MS physical 14657349 MSH2 Affinity Capture-Western physical 14657349 MSH2 Affinity Capture-Western physical 14657349 MSH2 Reconstituted Complex physical 14657349 CLSPN Affinity Capture-Western physical 12766152 CHD4 Affinity Capture-MS physical 10545197 HDAC2 Affinity Capture-Western physical 10545197 CHD4 Affinity Capture-Western physical 10545197 HDAC1 Affinity Capture-Western physical 10545197 MTA1 Affinity Capture-Western physical 10545197 MTA2 Affinity Capture-Western physical 10545197 CHD4 Affinity Capture-Western physical 10545197 HDAC2 Affinity Capture-Western physical 10545197 HDAC2 Co-purification physical 10545197 ATRIP Affinity Capture-Western physical 14657349 ATRIP Affinity Capture-Western physical 14657349 ATRIP Affinity Capture-Western physical 15210935 ATRIP Affinity Capture-MS physical 11721054 ATRIP Affinity Capture-Western physical 11721054 ATRIP Affinity Capture-Western physical 11721054 ATRIP Biochemical Activity physical 11721054 RHEB Reconstituted Complex physical 15854902 RHEB Affinity Capture-Western physical 15854902 RAD17 Affinity Capture-Western physical 11418864 RAD17 Biochemical Activity physical 11418864 H2AFX Co-localization physical 19805520 XPC Co-localization physical 19805520 BRCA1 Affinity Capture-Western physical 17478428 PMS1 Affinity Capture-Western physical 17148452 CDC6 Reconstituted Complex physical 20048340 CDC6 Affinity Capture-Western physical 20048340 TTI1 Affinity Capture-Western physical 20427287 TELO2 Affinity Capture-Western physical 20427287 MSH6 Affinity Capture-Western physical 20029092 MSH6 Affinity Capture-Western physical 20029092 FANCA Biochemical Activity physical 19109555 ATRIP Affinity Capture-Western physical 19097996 CLK2 Affinity Capture-Western physical 19097996 TOPBP1 Affinity Capture-Western physical 19097996 CLK2 Affinity Capture-Western physical 19097996 ATM Biochemical Activity physical 17124492 C19orf40 Co-fractionation physical 18995830 RPA2 Biochemical Activity physical 17035231 CHEK2 Biochemical Activity physical 17035231 MCPH1 Co-localization physical 16872911 TELO2 Affinity Capture-MS physical 20801936 TELO2 Affinity Capture-Western physical 20801936 UPF1 Biochemical Activity physical 16488880 SMC1A Affinity Capture-Western physical 15640246 ATRIP Affinity Capture-Western physical 18344416 Cep164 Affinity Capture-Western physical 18283122 ATRIP Affinity Capture-Western physical 18283122 Cep164 Affinity Capture-Western physical 18283122 ATRIP Affinity Capture-Western physical 18283122 Cep164 Reconstituted Complex physical 18283122 Cep164 Biochemical Activity physical 18283122 ATRIP Affinity Capture-Western physical 15451423 ATRIP Affinity Capture-Western physical 15451423 ATRIP Biochemical Activity physical 15451423 RAD1 Affinity Capture-Western physical 18162465 HUS1 Affinity Capture-Western physical 18162465 RAD9A Affinity Capture-Western physical 18162465 RPA1 Affinity Capture-Western physical 18162465 ATRIP Affinity Capture-Western physical 18162465 ATRIP Affinity Capture-MS physical 21285353 MSH2 Affinity Capture-MS physical 21285353 MSH2 Affinity Capture-Western physical 21285353 MSH2 Co-localization physical 21285353 POLN Biochemical Activity physical 21242293 BLM Affinity Capture-Western physical 14729972 BLM Affinity Capture-Western physical 14729972 BLM Biochemical Activity physical 14729972 EP300 Affinity Capture-Western physical 17272271 EP300 Affinity Capture-Western physical 17272271 EP300 Reconstituted Complex physical 17272271 MTA1 Affinity Capture-Western physical 20427275 MTA1 Affinity Capture-Western physical 20427275 SNIP1 Affinity Capture-Western physical 17260016 CLK2 Affinity Capture-MS physical 17384638 CLK2 Affinity Capture-Western physical 17384638 CLK2 Affinity Capture-Western physical 17384638 ATRIP Affinity Capture-Western physical 17384638 ATRIP Affinity Capture-Western physical 17384638 WRN Affinity Capture-Western physical 17118963 FANCD2 Biochemical Activity physical 16943440 E2F1 Biochemical Activity physical 11459832 TP53 Biochemical Activity physical 11459832 ATRIP Affinity Capture-Western physical 20847938 TP53 Biochemical Activity physical 20798688 ABL1 Affinity Capture-Western physical 20798688 ABL1 Biochemical Activity physical 20798688 NCOA2 Affinity Capture-MS physical 16051665 CHEK2 Biochemical Activity physical 10973490 CDK9 Affinity Capture-Western physical 20930849 HSP90AA1 Affinity Capture-Western physical 21566061 HSP90AA1 Affinity Capture-Western physical 21566061