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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for FBXW7 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0001944 vasculature development TAS GO:0007062 sister chromatid cohesion IMP GO:0007219 Notch signaling pathway IEA GO:0010868 negative regulation of triglyceride biosynthetic process ISS GO:0010883 regulation of lipid storage ISS GO:0016567 protein ubiquitination IDA GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA GO:0032876 negative regulation of DNA endoreduplication IMP GO:0032880 regulation of protein localization ISS GO:0044419 interspecies interaction between organisms IEA GO:0045741 positive regulation of epidermal growth factor-activated receptor activity IDA GO:0045746 negative regulation of Notch signaling pathway ISS GO:0050821 protein stabilization IDA GO:0055088 lipid homeostasis ISS GO:0070374 positive regulation of ERK1 and ERK2 cascade IMP GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA GO:2000346 negative regulation of hepatocyte proliferation ISS GO:2000639 negative regulation of SREBP-mediated signaling pathway ISS cellular_component GO:0005634 nucleus IEA GO:0005654 nucleoplasm IDA GO:0005654 nucleoplasm IEA GO:0005730 nucleolus IDA GO:0005730 nucleolus IEA GO:0005737 cytoplasm IEA GO:0005783 endoplasmic reticulum IEA GO:0005794 Golgi apparatus IEA GO:0019005 SCF ubiquitin ligase complex IDA GO:0048471 perinuclear region of cytoplasm IEA molecular_function GO:0003700 sequence-specific DNA binding transcription factor activity IEA GO:0005515 protein binding IPI

Protein-protein interaction details for FBXW7 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID NFKB2 Affinity Capture-MS physical 14743216 CCNE1 Biochemical Activity physical 14536078 PARK2 Affinity Capture-Western physical 12628165 PARK2 Affinity Capture-Western physical 12628165 PARK2 Reconstituted Complex physical 12628165 SKP1 Affinity Capture-Western physical 12628165 C6orf167 Two-hybrid physical 16169070 LINGO1 Two-hybrid physical 16169070 KIAA1875 Two-hybrid physical 16169070 SUMF2 Two-hybrid physical 16169070 ARL6IP1 Two-hybrid physical 16169070 SHPRH Two-hybrid physical 16169070 SKP1 Affinity Capture-Western physical 11585921 SKP1 Affinity Capture-Western physical 11585921 CUL1 Reconstituted Complex physical 11585921 SKP1 Reconstituted Complex physical 11585921 PSEN1 Affinity Capture-Western physical 12354302 NOTCH1 Affinity Capture-Western physical 11425854 MTOR Affinity Capture-Western physical 18787170 MYB Affinity Capture-Western physical 18765672 MYB Biochemical Activity physical 18765672 HIPK2 Affinity Capture-Western physical 18765672 PPARGC1A Affinity Capture-Western physical 18198341 PPARGC1A Affinity Capture-Western physical 18198341 PPARGC1A Reconstituted Complex physical 18198341 NOTCH1 Affinity Capture-Western physical 17646408 NOTCH1 Affinity Capture-Western physical 17646408 MYC Affinity Capture-Western physical 17646408 CCNE1 Affinity Capture-Western physical 17646408 SKP1 Co-crystal Structure physical 17434132 CCNE1 Co-crystal Structure physical 17434132 CCNE1 Affinity Capture-Western physical 17434132 CCNE1 Biochemical Activity physical 16818231 SREBF1 Affinity Capture-Western physical 16054087 SREBF1 Protein-peptide physical 16054087 CCNE1 Affinity Capture-Western physical 15980150 MYC Affinity Capture-Western physical 15498494 MYC Affinity Capture-Western physical 15150404 MYC Affinity Capture-Western physical 15103331 MYC Biochemical Activity physical 15103331 MYC Reconstituted Complex physical 15103331 KLF5 Affinity Capture-Western physical 20388706 KLF5 Reconstituted Complex physical 20388706 KLF5 Affinity Capture-Western physical 20388706 GNB2L1 Affinity Capture-Western physical 21860413 GNB2L1 Reconstituted Complex physical 21860413 CCNE2 Affinity Capture-Western physical 19084516 CCNE2 Biochemical Activity physical 19084516 MYC Affinity Capture-MS physical 17314511 MYCN Affinity Capture-Western physical 19111882 AURKA Affinity Capture-Western physical 19111882 MYCN Affinity Capture-Western physical 19111882 DCLRE1C Affinity Capture-Western physical 19423708 DCLRE1C Affinity Capture-Western physical 19423708 SREBF1 Affinity Capture-Western physical 19126544 MYC Affinity Capture-Western physical 20970423 HIF1A Affinity Capture-Western physical 21964756 EIF3E Affinity Capture-Western physical 20890303 SKP1 Affinity Capture-Western physical 21620836 FBXW7 Affinity Capture-Western physical 21620836 NFE2L1 Affinity Capture-Western physical 21953459 KLF5 Affinity Capture-Western physical 20484041 KLF5 Affinity Capture-Western physical 20484041 KLF5 Biochemical Activity physical 20484041 MYC Reconstituted Complex physical 20848231