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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for MAPK1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000165 MAPKKK cascade TAS GO:0000186 activation of MAPKK activity TAS GO:0000187 activation of MAPK activity TAS GO:0000189 MAPK import into nucleus IEA GO:0002224 toll-like receptor signaling pathway TAS GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS GO:0006917 induction of apoptosis TAS GO:0006935 chemotaxis TAS GO:0006950 response to stress TAS GO:0006974 response to DNA damage stimulus IEA GO:0007049 cell cycle IEA GO:0007165 signal transduction TAS GO:0007173 epidermal growth factor receptor signaling pathway TAS GO:0007264 small GTPase mediated signal transduction TAS GO:0007265 Ras protein signal transduction TAS GO:0007268 synaptic transmission TAS GO:0007411 axon guidance TAS GO:0007596 blood coagulation TAS GO:0008063 Toll signaling pathway TAS GO:0008284 positive regulation of cell proliferation IEA GO:0008286 insulin receptor signaling pathway TAS GO:0009636 response to toxin IEA GO:0009887 organ morphogenesis IEA GO:0019233 sensory perception of pain IEA GO:0019858 cytosine metabolic process IEA GO:0030168 platelet activation TAS GO:0030335 positive regulation of cell migration IEA GO:0031663 lipopolysaccharide-mediated signaling pathway IEA GO:0032496 response to lipopolysaccharide IEA GO:0033598 mammary gland epithelial cell proliferation IEA GO:0034130 toll-like receptor 1 signaling pathway TAS GO:0034134 toll-like receptor 2 signaling pathway TAS GO:0034138 toll-like receptor 3 signaling pathway TAS GO:0034142 toll-like receptor 4 signaling pathway TAS GO:0035556 intracellular signal transduction IEA GO:0043330 response to exogenous dsRNA IEA GO:0043627 response to estrogen stimulus IEA GO:0044419 interspecies interaction between organisms IEA GO:0045087 innate immune response TAS GO:0045596 negative regulation of cell differentiation IEA GO:0045727 positive regulation of translation IEA GO:0045893 positive regulation of transcription, DNA-dependent IEA GO:0048011 nerve growth factor receptor signaling pathway TAS GO:0050852 T cell receptor signaling pathway IEA GO:0050853 B cell receptor signaling pathway IEA GO:0051090 regulation of sequence-specific DNA binding transcription factor activity TAS GO:0051403 stress-activated MAPK cascade TAS GO:0060716 labyrinthine layer blood vessel development IEA GO:0070371 ERK1 and ERK2 cascade TAS cellular_component GO:0005625 soluble fraction IEA GO:0005626 insoluble fraction IEA GO:0005634 nucleus IEA GO:0005654 nucleoplasm IEA GO:0005654 nucleoplasm TAS GO:0005737 cytoplasm IEA GO:0005739 mitochondrion IEA GO:0005815 microtubule organizing center IEA GO:0005829 cytosol IEA GO:0005829 cytosol TAS GO:0005856 cytoskeleton IEA GO:0032839 dendrite cytoplasm IEA GO:0033267 axon part IEA GO:0043204 perikaryon IEA GO:0043234 protein complex IEA molecular_function GO:0000166 nucleotide binding IEA GO:0001784 phosphotyrosine binding IEA GO:0003677 DNA binding IEA GO:0004674 protein serine/threonine kinase activity IEA GO:0004707 MAP kinase activity IEA GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0008134 transcription factor binding IEA GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity IEA GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity ISS GO:0019902 phosphatase binding IPI GO:0031435 mitogen-activated protein kinase kinase kinase binding IEA

Protein-protein interaction details for MAPK1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID NEK2 Two-hybrid physical 15358203 MYC Reconstituted Complex physical 15210690 AR Reconstituted Complex physical 10318905 NEK2 Affinity Capture-Western physical 15358203 NEK2 Reconstituted Complex physical 15358203 SORBS3 Biochemical Activity physical 15184391 SORBS3 Affinity Capture-Western physical 15184391 MAPKAPK2 Affinity Capture-Western physical 15094067 ATP1A1 Biochemical Activity physical 15069082 FHL2 Two-hybrid physical 14729955 FHL2 Reconstituted Complex physical 14729955 FHL2 Reconstituted Complex physical 14729955 FHL2 Affinity Capture-Western physical 14729955 MKNK2 Affinity Capture-Western physical 12897141 RPS6KA1 Affinity Capture-Western physical 12832467 RPS6KA2 Affinity Capture-Western physical 12832467 CASP9 Biochemical Activity physical 12792650 MAP2K1 Affinity Capture-Western physical 12697810 MAP2K1 Biochemical Activity physical 12697810 MAPK14 Affinity Capture-Western physical 12697810 ELK1 Biochemical Activity physical 12594221 RPS6KA1 Biochemical Activity physical 12594221 UBR5 Biochemical Activity physical 12594221 TPR Biochemical Activity physical 12594221 UBR5 Affinity Capture-Western physical 12594221 RPS6KA5 Phenotypic Enhancement genetic 9687510 RPS6KA3 Affinity Capture-Western physical 8939914 RPS6KA2 Affinity Capture-Western physical 8939914 ADAM17 Reconstituted Complex physical 12058067 ADAM17 Biochemical Activity physical 12058067 ADAM17 Affinity Capture-Western physical 12058067 PTPN7 Affinity Capture-Western physical 10702794 PTPN7 Biochemical Activity physical 10702794 MAP2K1 Two-hybrid physical 11823456 MAP2K2 Two-hybrid physical 11823456 DUSP22 Biochemical Activity physical 11346645 DUSP22 Affinity Capture-Western physical 11346645 RAF1 Affinity Capture-Western physical 11409918 INSR Affinity Capture-Western physical 11409918 PRKCE Affinity Capture-Western physical 11350735 ESR1 Reconstituted Complex physical 12093745 MAP2K1 Reconstituted Complex physical 10757792 PEBP1 Reconstituted Complex physical 10757792 MAP2K1 Reconstituted Complex physical 10757792 PEBP1 Reconstituted Complex physical 10757792 MYC Reconstituted Complex physical 7957875 PTPRR Reconstituted Complex physical 9857190 PTPN5 Reconstituted Complex physical 9857190 SNCG Affinity Capture-Western physical 12121974 SNCA Affinity Capture-Western physical 12121974 MAPKSP1 Reconstituted Complex physical 11266467 MAP2K1 Reconstituted Complex physical 11266467 MKNK2 Reconstituted Complex physical 9155017 MKNK1 Reconstituted Complex physical 9155017 MKNK2 Two-hybrid physical 9155017 MKNK1 Two-hybrid physical 9155017 VAV1 Affinity Capture-Western physical 8900182 TSC2 Reconstituted Complex physical 15851026 TSC2 Affinity Capture-Western physical 15851026 RPS6KA1 Reconstituted Complex physical 9915826 RPS6KA3 Affinity Capture-Western physical 9915826 GATA4 Biochemical Activity physical 11585926 IER3 Biochemical Activity physical 12356731 PECAM1 Affinity Capture-Western physical 10801826 TNIP1 Two-hybrid physical 12220502 TNIP1 Reconstituted Complex physical 12220502 TNIP1 Affinity Capture-Western physical 12220502 TNKS2 Biochemical Activity physical 10988299 HMMR Affinity Capture-Western physical 11403955 STAT5A Reconstituted Complex physical 10194762 STAT5A Affinity Capture-Western physical 10194762 DYRK1B Biochemical Activity physical 10910078 DUSP3 Biochemical Activity physical 10224087 DUSP3 Affinity Capture-Western physical 10224087 PEA15 Two-hybrid physical 11702783 PEA15 Reconstituted Complex physical 11702783 CEBPB Biochemical Activity physical 11500490 ATF2 Biochemical Activity physical 7737129 MAP3K1 Affinity Capture-Western physical 10969079 MAP3K1 Affinity Capture-Western physical 10969079 VAV1 Affinity Capture-Western physical 9013873 DUSP16 Affinity Capture-Western physical 11489891 MAPK14 Affinity Capture-Western physical 11157753 MAP2K1 Biochemical Activity physical 11352917 MAP2K1 Affinity Capture-Western physical 11352917 PTPN7 Affinity Capture-Western physical 10206983 STAT5A Affinity Capture-Western physical 10996427 SHC1 Affinity Capture-Western physical 10996427 C1QBP Biochemical Activity physical 11866440 ELK1 Reconstituted Complex physical 8586671 ELK1 Biochemical Activity physical 8586671 DUSP1 Two-hybrid physical 11278799 DUSP1 Affinity Capture-Western physical 11278799 TOB1 Two-hybrid physical 12151396 TOB1 Affinity Capture-Western physical 12151396 TOB1 Reconstituted Complex physical 12151396 TOB1 Biochemical Activity physical 12151396 DUSP6 Reconstituted Complex physical 9535927 HDAC4 Affinity Capture-Western physical 11114188 HDAC4 Biochemical Activity physical 11114188 SREBF1 Biochemical Activity physical 10627507 SREBF2 Biochemical Activity physical 10627507 MAP2K1 Biochemical Activity physical 11279118 MYC Biochemical Activity physical 9207092 TP53 Affinity Capture-Western physical 10958792 TH Biochemical Activity physical 1347949 KRT8 Biochemical Activity physical 11788583 DUSP1 Affinity Capture-Western physical 18519678 CIITA Biochemical Activity physical 18245089 CIITA Affinity Capture-Western physical 18245089 CIITA Affinity Capture-Western physical 18245089 UBC Affinity Capture-Western physical 17327227 JUN Affinity Capture-Western physical 11431474 FOS Affinity Capture-Western physical 11431474 ALK Affinity Capture-MS physical 14968112 CDC25C Affinity Capture-Western physical 16582626 CDC25C Reconstituted Complex physical 16582626 MTPN Two-hybrid physical 20936779 PGR Affinity Capture-Western physical 17081988 PGR Affinity Capture-Western physical 17081988 ARRB2 Affinity Capture-Western physical 15699045 JUND Affinity Capture-Western physical 16264271 TFCP2 Biochemical Activity physical 15857981 ESR2 Biochemical Activity physical 11358671 ESR1 Biochemical Activity physical 11358671 ARHGEF2 Affinity Capture-Western physical 18211802 ELK1 Biochemical Activity physical 10644696 TOP2A Reconstituted Complex physical 10207078 TOP2A Biochemical Activity physical 10207078 CENPE Biochemical Activity physical 9744883 CENPE Affinity Capture-Western physical 9744883 CENPE Affinity Capture-Western physical 9744883 SPRY2 Affinity Capture-Western physical 11983899 EP300 Affinity Capture-Western physical 17623675 EP300 Biochemical Activity physical 17623675 VDR Biochemical Activity physical 20371703 HNF4A Biochemical Activity physical 20371703 RXRA Biochemical Activity physical 20371703 ELK1 Biochemical Activity physical 20371703 SFPQ Affinity Capture-Western physical 20371701 SFPQ Affinity Capture-Western physical 20371701 CCND1 Affinity Capture-Western physical 17205132 SMAD1 Biochemical Activity physical 17289590 RYK Affinity Capture-MS physical 21875946 DCC Affinity Capture-Western physical 20434207 DCC Affinity Capture-MS physical 20434207 ARRB2 Affinity Capture-Western physical 11226259 AGTR1 Affinity Capture-Western physical 11226259 PPP1CC Affinity Capture-Western physical 12624094 C1orf151 Affinity Capture-MS physical 22114354 CSDA Biochemical Activity physical 16198352 YBX1 Biochemical Activity physical 16198352 NUP153 Reconstituted Complex physical 17255949 PEA15 Affinity Capture-Western physical 17255949 CTSD Two-hybrid physical 18624398 GAPDH Two-hybrid physical 18624398 ID2 Two-hybrid physical 18624398 IFI35 Two-hybrid physical 18624398 GTF2I Affinity Capture-Western physical 11313464 ARRB1 Biochemical Activity physical 10347142 PTPRR Reconstituted Complex physical 10419510 JUN Biochemical Activity physical 10419510 JUN Reconstituted Complex physical 10419510 PTPRR Affinity Capture-Western physical 10419510 PTPRR Biochemical Activity physical 10419510 PTPRR Reconstituted Complex physical 10419510 PTPRR Biochemical Activity physical 10419510 DUSP1 Biochemical Activity physical 10617468 TNFRSF1A Biochemical Activity physical 11606045 TNFRSF25 Biochemical Activity physical 11606045 UBTF Biochemical Activity physical 11741541 SP1 Biochemical Activity physical 11904305 TP53 Affinity Capture-Western physical 21147777 RARA Biochemical Activity physical 12048211 RARA Affinity Capture-Western physical 12048211 CAV1 Affinity Capture-Western physical 12388423 PTPRE Affinity Capture-Western physical 12754301 UBC Affinity Capture-MS physical 18781797 NCOA3 Biochemical Activity physical 15383283 CDT1 Affinity Capture-Western physical 21930785 CDT1 Biochemical Activity physical 21930785