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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for BARD1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0001894 tissue homeostasis TAS GO:0006281 DNA repair IEA GO:0006974 response to DNA damage stimulus NAS GO:0007050 cell cycle arrest NAS GO:0007283 spermatogenesis IEA GO:0016567 protein ubiquitination NAS GO:0031441 negative regulation of mRNA 3'-end processing NAS GO:0042325 regulation of phosphorylation IMP GO:0043065 positive regulation of apoptosis IMP GO:0043066 negative regulation of apoptosis IMP GO:0045732 positive regulation of protein catabolic process NAS GO:0046826 negative regulation of protein export from nucleus IDA GO:0085020 protein K6-linked ubiquitination IDA cellular_component GO:0000151 ubiquitin ligase complex NAS GO:0005622 intracellular IEA GO:0005634 nucleus IDA GO:0005634 nucleus IMP GO:0005737 cytoplasm IDA GO:0031436 BRCA1-BARD1 complex IDA GO:0070531 BRCA1-A complex IDA molecular_function GO:0003723 RNA binding IDA GO:0004842 ubiquitin-protein ligase activity IDA GO:0004842 ubiquitin-protein ligase activity NAS GO:0005515 protein binding IPI GO:0008270 zinc ion binding IEA GO:0016874 ligase activity IEA GO:0019900 kinase binding NAS GO:0042803 protein homodimerization activity IPI GO:0046872 metal ion binding IEA GO:0046982 protein heterodimerization activity IPI

Protein-protein interaction details for BARD1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID BCL3 Two-hybrid physical 10362352 BRCA1 Two-hybrid physical 8944023 CSTF1 Two-hybrid physical 10477523 CSTF1 Two-hybrid physical 11257228 BRCA1 Two-hybrid physical 11498787 BRCA1 Reconstituted Complex physical 11498787 BRCA1 Reconstituted Complex physical 12485996 H2AFX Reconstituted Complex physical 12485996 UBA1 Reconstituted Complex physical 12485996 UBE2D1 Reconstituted Complex physical 12485996 BRCA1 Reconstituted Complex physical 12890688 BRCA1 Reconstituted Complex physical 11278247 RELA Affinity Capture-Western physical 12700228 MSH2 Reconstituted Complex physical 11498787 BRCA1 Co-localization physical 11925436 BRCA1 Co-localization physical 14647430 BRCA1 Affinity Capture-Western physical 12732733 BRCA1 Reconstituted Complex physical 14638690 XIST Co-localization physical 12419249 BRCA1 Co-purification physical 14636569 BRCA1 Reconstituted Complex physical 14636569 BRCA2 Reconstituted Complex physical 14636569 BRCA2 Co-purification physical 14636569 BRE Affinity Capture-MS physical 14636569 BRE Affinity Capture-Western physical 14636569 BRCC3 Affinity Capture-MS physical 14636569 BRCC3 Affinity Capture-Western physical 14636569 RAD51 Affinity Capture-MS physical 14636569 RAD51 Affinity Capture-Western physical 14636569 EWSR1 Affinity Capture-Western physical 12183411 EWSR1 Reconstituted Complex physical 12183411 EWSR1 FRET physical 12183411 EWSR1 Two-hybrid physical 12183411 BRCA1 Co-purification physical 11504724 BRCA1 Affinity Capture-Western physical 11257228 BRCA1 Co-purification physical 11257228 BRCA1 Reconstituted Complex physical 11257228 CSTF1 Reconstituted Complex physical 11257228 CSTF2 Affinity Capture-Western physical 11257228 CSTF2 Co-purification physical 11257228 TP53 Affinity Capture-Western physical 14636569 CSTF1 Reconstituted Complex physical 10477523 CSTF2 Affinity Capture-Western physical 10477523 CSTF2 Co-purification physical 10477523 BRCA1 Affinity Capture-Western physical 8944023 BRCA1 Two-hybrid physical 11773071 BRCA1 Reconstituted Complex physical 11526114 BRCA1 Reconstituted Complex physical 12431996 BRCA1 FRET physical 10026184 BRCA1 Reconstituted Complex physical 12438698 UBA1 Reconstituted Complex physical 12438698 UBE2D1 Reconstituted Complex physical 12438698 H2AFX Reconstituted Complex physical 11927591 HIST2H2AB Reconstituted Complex physical 11927591 UBA1 Reconstituted Complex physical 11927591 UBE2D1 Reconstituted Complex physical 11927591 BRCA1 Reconstituted Complex physical 11927591 UBA1 Reconstituted Complex physical 12431996 UBE2D2 Reconstituted Complex physical 12431996 BRCA1 Affinity Capture-Western physical 11278247 BARD1 Reconstituted Complex physical 11257228 BRCA1 Affinity Capture-Western physical 15159397 BRCA1 Reconstituted Complex physical 11573085 BRCA1 Affinity Capture-Western physical 9738006 BRCA1 Co-localization physical 9342365 BRCA1 Co-localization physical 10635334 BRCA1 Affinity Capture-Western physical 15159397 BRCA1 Affinity Capture-Western physical 10477523 BRCA1 Co-purification physical 10477523 CSTF1 Two-hybrid physical 10477523 MSH3 Reconstituted Complex physical 11498787 MSH6 Reconstituted Complex physical 11498787 TP53 Affinity Capture-MS physical 14636569 UBA1 Reconstituted Complex physical 11278247 UBE2D1 Reconstituted Complex physical 14636569 UBE2D1 Reconstituted Complex physical 12890688 UBE2D1 Reconstituted Complex physical 11278247 UBE3A Reconstituted Complex physical 12890688 BRCA1 Two-hybrid physical 12951069 BRCA1 Co-crystal Structure physical 12732733 BRCA1 Affinity Capture-Western physical 12700228 NFKBIA Two-hybrid physical 10362352 BCL3 Reconstituted Complex physical 10362352 MED17 Co-purification physical 12154023 BRCA1 Co-purification physical 10026184 RBBP8 Affinity Capture-Western physical 10764811 BRCA1 Affinity Capture-Western physical 11301010 BRCA1 Reconstituted Complex physical 9788437 BRCA1 Affinity Capture-Western physical 19176389 BRCA2 Affinity Capture-Western physical 19176389 AURKB Affinity Capture-Western physical 19176389 TACC1 Affinity Capture-Western physical 19176389 BRCA1 Affinity Capture-Western physical 19176389 TACC1 Affinity Capture-Western physical 19176389 BRCA2 Affinity Capture-Western physical 19176389 AURKB Affinity Capture-Western physical 19176389 NR1H3 Affinity Capture-Western physical 19164445 BRCA1 Affinity Capture-Western physical 19117993 BRCA1 Reconstituted Complex physical 19117993 BRCA1 Affinity Capture-Western physical 17525341 UIMC1 Affinity Capture-Western physical 17525341 BRCC3 Affinity Capture-Western physical 17525341 UIMC1 Affinity Capture-MS physical 19615732 BRCA1 Two-hybrid physical 20215511 UBE2U Two-hybrid physical 19690564 BRCA1 Affinity Capture-Western physical 16489000 TP53 Affinity Capture-Western physical 15782130 XRCC6 Affinity Capture-Western physical 15782130 XRCC6 Affinity Capture-Western physical 15782130 BRCA1 Affinity Capture-Western physical 18936166 XRCC5 Affinity Capture-Western physical 18936166 NPM1 Affinity Capture-Western physical 15184379 NPM1 Affinity Capture-Western physical 15184379 BACH1 Affinity Capture-Western physical 17664283 BRCA1 Affinity Capture-Western physical 17664283 BRCA2 Affinity Capture-Western physical 17664283 BRCC3 Affinity Capture-Western physical 17664283 BACH1 Affinity Capture-Western physical 17664283 BRCC3 Affinity Capture-Western physical 17664283 BRCA1 Affinity Capture-Western physical 17664283 UBC Reconstituted Complex physical 17218787 HTT Two-hybrid physical 15383276 GIT1 Reconstituted Complex physical 15383276 MYST2 Reconstituted Complex physical 15383276 HAP1 Reconstituted Complex physical 15383276 TCERG1 Reconstituted Complex physical 15383276 ESR1 Affinity Capture-Western physical 20060929 BRCA1 Affinity Capture-Western physical 20060929 ESR1 Affinity Capture-Western physical 20060929 BRCA1 Affinity Capture-Western physical 20060929 FAM175A Affinity Capture-MS physical 19261749 POLR2H Affinity Capture-Western physical 17283126 POLR2H Biochemical Activity physical 17283126 BRCA2 Co-purification physical 16391231 BRCA1 Co-purification physical 16391231 RAD50 Co-purification physical 16391231 MSH6 Co-purification physical 16391231 SMC1A Co-purification physical 16391231 BACH1 Co-purification physical 16391231 RBBP8 Co-purification physical 16391231 BARD1 Co-purification physical 16391231 MLH1 Co-purification physical 16391231 TOPBP1 Co-purification physical 16391231 NBN Co-purification physical 16391231 TOPBP1 Affinity Capture-Western physical 16391231 NBN Affinity Capture-Western physical 16391231 BRCA1 Affinity Capture-Western physical 16391231 RAD50 Affinity Capture-Western physical 16391231 BACH1 Affinity Capture-Western physical 16391231 RBBP8 Affinity Capture-Western physical 16391231 MRE11A Affinity Capture-Western physical 16391231 BACH1 Co-localization physical 16391231 BRCA1 Co-localization physical 16391231 RBBP8 Affinity Capture-Western physical 16391231 BACH1 Affinity Capture-Western physical 16391231 FAM175A Affinity Capture-MS physical 19261748 RBBP8 Affinity Capture-Western physical 20351172 UBXN1 Affinity Capture-Western physical 20351172 UBXN1 Reconstituted Complex physical 20351172 BRCA1 Biochemical Activity physical 20351172 BARD1 Biochemical Activity physical 21965653 UBC Reconstituted Complex physical 21965653 BRCA1 Affinity Capture-Western physical 21901007