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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for SHC1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000165 MAPKKK cascade IDA GO:0000187 activation of MAPK activity IDA GO:0000187 activation of MAPK activity IEA GO:0001525 angiogenesis IEA GO:0001666 response to hypoxia IEA GO:0007173 epidermal growth factor receptor signaling pathway TAS GO:0007176 regulation of epidermal growth factor-activated receptor activity TAS GO:0007265 Ras protein signal transduction TAS GO:0007507 heart development IEA GO:0007568 aging IEA GO:0007596 blood coagulation TAS GO:0008284 positive regulation of cell proliferation NAS GO:0008286 insulin receptor signaling pathway IEA GO:0008286 insulin receptor signaling pathway ISS GO:0008286 insulin receptor signaling pathway TAS GO:0008543 fibroblast growth factor receptor signaling pathway TAS GO:0009636 response to toxin IEA GO:0016337 cell-cell adhesion IEA GO:0030182 neuron differentiation IEA GO:0031100 organ regeneration IEA GO:0031175 neuron projection development IEA GO:0031532 actin cytoskeleton reorganization IEA GO:0032868 response to insulin stimulus IEA GO:0035094 response to nicotine IEA GO:0035556 intracellular signal transduction IEA GO:0040008 regulation of growth IEA GO:0042542 response to hydrogen peroxide IEA GO:0045740 positive regulation of DNA replication IEA GO:0045740 positive regulation of DNA replication ISS GO:0045907 positive regulation of vasoconstriction IEA GO:0048011 nerve growth factor receptor signaling pathway TAS GO:0048661 positive regulation of smooth muscle cell proliferation IEA GO:0050900 leukocyte migration TAS GO:0051384 response to glucocorticoid stimulus IEA cellular_component GO:0005634 nucleus IEA GO:0005737 cytoplasm IEA GO:0005739 mitochondrion IEA GO:0005759 mitochondrial matrix IEA GO:0005829 cytosol TAS GO:0005886 plasma membrane IDA GO:0005886 plasma membrane IEA GO:0010008 endosome membrane IEA GO:0070435 Shc-EGFR complex IEA GO:0070435 Shc-EGFR complex ISS molecular_function GO:0001784 phosphotyrosine binding IEA GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity TAS GO:0005154 epidermal growth factor receptor binding IEA GO:0005154 epidermal growth factor receptor binding ISS GO:0005158 insulin receptor binding IPI GO:0005159 insulin-like growth factor receptor binding IPI GO:0005515 protein binding IPI GO:0005543 phospholipid binding TAS GO:0032403 protein complex binding IEA GO:0046875 ephrin receptor binding IPI GO:0051219 phosphoprotein binding IEA

Protein-protein interaction details for SHC1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID FLT1 Two-hybrid physical 10749680 DDR2 Two-hybrid physical 11884411 PTPN12 Two-hybrid physical 7929214 MAPKAPK2 Two-hybrid physical 15094067 CALCOCO2 Two-hybrid physical 16189514 EGFR Affinity Capture-MS physical 16729043 ERBB2 Affinity Capture-MS physical 16729043 ERBB3 Affinity Capture-MS physical 16729043 ERBB4 Affinity Capture-MS physical 16729043 PIK3R1 Reconstituted Complex physical 7537361 DOK1 Affinity Capture-Western physical 10822173 DOK2 Affinity Capture-Western physical 10822173 DOK1 Affinity Capture-Western physical 10822173 INPP5D Affinity Capture-Western physical 10822173 INPP5D Affinity Capture-Western physical 10822173 MAPKAPK2 Affinity Capture-Western physical 15094067 MAPKAPK2 Biochemical Activity physical 15094067 PLSCR1 Affinity Capture-Western physical 12871937 PLSCR1 Reconstituted Complex physical 12871937 LRP1 Affinity Capture-Western physical 12789267 LRP1 Reconstituted Complex physical 12789267 GRB2 Affinity Capture-MS physical 12577067 CDH5 Affinity Capture-Western physical 11950700 KDR Affinity Capture-Western physical 11950700 IL2RB Reconstituted Complex physical 10602027 ABL1 Affinity Capture-Western physical 10194451 INPP5D Affinity Capture-Western physical 10194451 INPPL1 Affinity Capture-Western physical 10194451 INPPL1 Affinity Capture-MS physical 10194451 CD22 Affinity Capture-Western physical 10748054 CD22 Affinity Capture-Western physical 10748054 IL4R Affinity Capture-Western physical 10652211 PLCG2 Affinity Capture-Western physical 10623845 ITGB4 Far Western physical 11044453 INPPL1 Affinity Capture-Western physical 11349134 GRB2 Affinity Capture-Western physical 8491186 GRB2 Affinity Capture-Western physical 8491186 ERBB2 Affinity Capture-Western physical 10085134 ABL1 Affinity Capture-Western physical 8112292 GRB2 Affinity Capture-Western physical 8112292 GRB2 Affinity Capture-Western physical 8647288 PTK2 Affinity Capture-Western physical 11980671 EPHA2 Affinity Capture-Western physical 12400011 EPHA2 Reconstituted Complex physical 12400011 GRB2 Reconstituted Complex physical 8662733 GRB2 Affinity Capture-Western physical 8662733 GRB2 Affinity Capture-Western physical 8662733 PLCG1 Affinity Capture-Western physical 8662733 LRP1 Affinity Capture-Western physical 11854294 EGFR Affinity Capture-Western physical 9544989 CBLB Affinity Capture-Western physical 9614102 CEACAM1 Affinity Capture-Western physical 11694516 CSF3R Affinity Capture-Western physical 9824671 CSF3R Far Western physical 9824671 INPP5D Affinity Capture-Western physical 12024011 PRKCD Affinity Capture-Western physical 12024011 PRKCD Reconstituted Complex physical 12024011 IL4R Reconstituted Complex physical 11714803 ALK Affinity Capture-Western physical 11888936 FLT4 Reconstituted Complex physical 7970715 FLT4 Affinity Capture-Western physical 7970715 SOS1 Affinity Capture-Western physical 10675333 SOS2 Affinity Capture-Western physical 10675333 RET Affinity Capture-Western physical 9047384 RET Reconstituted Complex physical 9047384 CSF2RB Affinity Capture-Western physical 10704825 IL2RG Affinity Capture-Western physical 8643566 IGF1R Two-hybrid physical 8776723 PLCG2 Affinity Capture-Western physical 12135708 GAB2 Affinity Capture-Western physical 12135708 PTPN12 Affinity Capture-Western physical 8626541 PTPN12 Reconstituted Complex physical 8626541 SOS1 Affinity Capture-Western physical 10783152 SHCBP1 Two-hybrid physical 10086341 SHCBP1 Affinity Capture-Western physical 10086341 SHCBP1 Reconstituted Complex physical 10086341 IGF1R Affinity Capture-Western physical 16113100 DAG1 Reconstituted Complex physical 11724572 DAG1 Affinity Capture-Western physical 11724572 NTRK1 Two-hybrid physical 9856458 ZAP70 Affinity Capture-Western physical 9685404 ZAP70 Biochemical Activity physical 9685404 RET Affinity Capture-Western physical 8183561 NTRK1 Affinity Capture-Western physical 8183561 NTRK1 Two-hybrid physical 12446789 PAG1 Reconstituted Complex physical 10790433 GRB2 Affinity Capture-Western physical 9083103 GRB2 Affinity Capture-Western physical 9927207 FLT4 Affinity Capture-Western physical 9927207 KDR Affinity Capture-Western physical 10319320 EPOR Affinity Capture-Western physical 8400282 IRS1 Reconstituted Complex physical 7499194 VAV3 Affinity Capture-Western physical 11094073 CSK Reconstituted Complex physical 12048194 PTPN12 Reconstituted Complex physical 7929214 PTPN12 Affinity Capture-Western physical 7929214 PLSCR1 Affinity Capture-Western physical 12009895 AP2A2 Affinity Capture-Western physical 8617812 AP2A2 Reconstituted Complex physical 8617812 GRB2 Affinity Capture-Western physical 8294403 IL2RB Affinity Capture-Western physical 8294403 NTRK1 Reconstituted Complex physical 10092678 NTRK2 Reconstituted Complex physical 10092678 NTRK3 Reconstituted Complex physical 10092678 ESR1 Affinity Capture-Western physical 11773443 ESR1 Reconstituted Complex physical 11773443 GRB2 Affinity Capture-Western physical 12441060 APP Reconstituted Complex physical 11877420 APP Affinity Capture-Western physical 11877420 GRB2 Affinity Capture-Western physical 10477741 GRB2 Affinity Capture-Western physical 11302736 NGFR Affinity Capture-Western physical 7541035 GAB2 Affinity Capture-Western physical 11782427 ERBB2 Affinity Capture-Western physical 9710588 LYN Affinity Capture-Western physical 7650013 SOS1 Affinity Capture-Western physical 10570290 GRB2 Affinity Capture-Western physical 10570290 GRB2 Affinity Capture-Western physical 10570290 CBL Affinity Capture-Western physical 10570290 CBL Affinity Capture-Western physical 9461587 INPP5D Affinity Capture-Western physical 8643691 INPP5D Affinity Capture-Western physical 8643691 EPS8 Affinity Capture-Western physical 7791787 EPS8 Reconstituted Complex physical 7791787 GRB2 Affinity Capture-Western physical 11505033 PDGFRB Affinity Capture-Western physical 8195171 GRB2 Affinity Capture-Western physical 8195171 PDGFRB Affinity Capture-Western physical 8195171 CRKL Affinity Capture-Western physical 9344843 SOS1 Affinity Capture-Western physical 9344843 RAPGEF1 Affinity Capture-Western physical 9344843 MAPK1 Affinity Capture-Western physical 10996427 STAT5A Affinity Capture-Western physical 10996427 STAT5B Affinity Capture-Western physical 10996427 GRB2 Affinity Capture-Western physical 11964172 GRB2 Affinity Capture-Western physical 10080542 GRB2 Reconstituted Complex physical 7524086 GH1 Biochemical Activity physical 7535773 JAK2 Reconstituted Complex physical 7535773 GHR Reconstituted Complex physical 7535773 GRB2 Co-fractionation physical 7535773 FLT4 Affinity Capture-Western physical 8662748 FLT4 Reconstituted Complex physical 8662748 MET Affinity Capture-Western physical 9660480 PIK3C2B Reconstituted Complex physical 11533253 CALD1 Affinity Capture-Western physical 10559276 INPP5D Affinity Capture-Western physical 10900203 MST1R Affinity Capture-Western physical 8918464 GRB2 Affinity Capture-Western physical 9045692 INPPL1 Affinity Capture-Western physical 9660833 NTRK1 Two-hybrid physical 10708759 DDR2 Affinity Capture-Western physical 11884411 GRB2 Affinity Capture-Western physical 7514169 DDR1 Reconstituted Complex physical 9659899 IL6ST Affinity Capture-Western physical 9126968 JAK2 Reconstituted Complex physical 9126968 IL6ST Reconstituted Complex physical 9126968 GRB2 Reconstituted Complex physical 9126968 INSR Two-hybrid physical 10803466 FCGR2B Affinity Capture-Western physical 8940017 IGF1R Two-hybrid physical 7559507 HIF1A Affinity Capture-Western physical 12114320 GRB2 Reconstituted Complex physical 15812354 CSF3R PCA physical 17001306 UBC Affinity Capture-Western physical 21264241 UBC Affinity Capture-Western physical 21264241 EGFR Affinity Capture-MS physical 19531499 EGFR Reconstituted Complex physical 19531499 HMOX2 Two-hybrid physical 21900206 OSGEP Two-hybrid physical 21900206 CBLC Two-hybrid physical 21900206 NUDT21 Two-hybrid physical 21900206 MRPL44 Two-hybrid physical 21900206 ILK Two-hybrid physical 21900206 FAM118B Two-hybrid physical 21900206 SUV39H2 Two-hybrid physical 21900206 DUSP23 Two-hybrid physical 21900206 MAPK6 Two-hybrid physical 21900206 PRKRA Two-hybrid physical 21900206 GEMIN7 Two-hybrid physical 21900206 C11orf58 Two-hybrid physical 21900206