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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for SIAH2 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0006511 ubiquitin-dependent protein catabolic process IEA GO:0007049 cell cycle IEA GO:0007264 small GTPase mediated signal transduction TAS GO:0007275 multicellular organismal development IEA GO:0007411 axon guidance TAS GO:0043066 negative regulation of apoptosis IMP GO:0043154 negative regulation of caspase activity IMP GO:0044257 cellular protein catabolic process IGI GO:0090090 negative regulation of canonical Wnt receptor signaling pathway IGI cellular_component GO:0005634 nucleus IEA GO:0005737 cytoplasm IEA GO:0005829 cytosol IDA GO:0005829 cytosol TAS molecular_function GO:0003714 transcription corepressor activity TAS GO:0004842 ubiquitin-protein ligase activity IEA GO:0005515 protein binding IPI GO:0008270 zinc ion binding IEA GO:0016874 ligase activity IEA GO:0046872 metal ion binding IEA

Protein-protein interaction details for SIAH2 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID PEG10 Two-hybrid physical 12810624 RBBP8 Reconstituted Complex physical 14654780 PEG10 Reconstituted Complex physical 12810624 TRAF2 Reconstituted Complex physical 12411493 PEG3 Affinity Capture-Western physical 10681424 PEG3 Two-hybrid physical 10681424 SYP Two-hybrid physical 11786535 SYP Reconstituted Complex physical 11786535 UBE2L6 Co-fractionation physical 11786535 VAV1 Two-hybrid physical 10207103 VAV1 Reconstituted Complex physical 10207103 VAV1 Affinity Capture-Western physical 10207103 AKAP1 Affinity Capture-Western physical 18323779 PIAS1 Two-hybrid physical 17533377 PIAS2 Two-hybrid physical 17533377 UBE2I Two-hybrid physical 17533377 PIAS1 Reconstituted Complex physical 17533377 PIAS3 Reconstituted Complex physical 17533377 PIAS1 Affinity Capture-Western physical 17533377 PIAS1 Biochemical Activity physical 17533377 SNCAIP Biochemical Activity physical 16174773 DLST Reconstituted Complex physical 15466852 DLST Affinity Capture-Western physical 15466852 DLST Affinity Capture-Western physical 15466852 SNCA Biochemical Activity physical 15064394 EGLN2 Affinity Capture-Western physical 16958618 EGLN1 Affinity Capture-Western physical 16958618 EGLN3 Affinity Capture-Western physical 16958618 PLCE1 Affinity Capture-Western physical 17998205 PLCE1 Reconstituted Complex physical 17998205 PLCE1 Affinity Capture-Western physical 17998205 USP13 Affinity Capture-Western physical 21659512 USP13 Reconstituted Complex physical 21659512 SPRY2 Reconstituted Complex physical 16888801 HIPK2 Reconstituted Complex physical 19043406 HIPK2 Affinity Capture-Western physical 19043406 HIPK2 Affinity Capture-Western physical 19043406 UBC Affinity Capture-Western physical 19043406 UBC Affinity Capture-Western physical 19043406 HIPK2 Biochemical Activity physical 19043406 HDAC3 Affinity Capture-Western physical 20691163 SKI Affinity Capture-Western physical 20691163 SNCA Biochemical Activity physical 18070888 SNCA Affinity Capture-Western physical 18070888 SNCA Biochemical Activity physical 19224863 PSMD4 Biochemical Activity physical 19240029 TINF2 Affinity Capture-Western physical 22064479 TINF2 Affinity Capture-Western physical 22064479 TINF2 Biochemical Activity physical 22064479 TINF2 Two-hybrid physical 22064479 SNCA Biochemical Activity physical 22065755