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Gene
Protein
Transcript
Promoter
Expression
GO/PPI
PubMed
Cross reference
Gene Ontology information for BMP4 (
Homo sapiens
)
(Information is obtained from AmiGO)
ID
Term
Evidence
biological_process
GO:0000122
negative regulation of transcription from RNA polymerase II promoter
IDA
GO:0000186
activation of MAPKK activity
IDA
GO:0001525
angiogenesis
IEA
GO:0001541
ovarian follicle development
IEA
GO:0001568
blood vessel development
IEA
GO:0001649
osteoblast differentiation
IDA
GO:0001657
ureteric bud development
IDA
GO:0001658
branching involved in ureteric bud morphogenesis
IDA
GO:0001759
organ induction
IEA
GO:0001822
kidney development
IMP
GO:0001823
mesonephros development
IEP
GO:0001843
neural tube closure
IEA
GO:0001934
positive regulation of protein phosphorylation
IDA
GO:0001938
positive regulation of endothelial cell proliferation
IDA
GO:0001958
endochondral ossification
ISS
GO:0002043
blood vessel endothelial cell proliferation involved in sprouting angiogenesis
IDA
GO:0002062
chondrocyte differentiation
ISS
GO:0002244
hemopoietic progenitor cell differentiation
IDA
GO:0002320
lymphoid progenitor cell differentiation
IMP
GO:0003014
renal system process
IEA
GO:0003130
BMP signaling pathway involved in heart induction
IMP
GO:0003139
secondary heart field specification
IMP
GO:0003197
endocardial cushion development
TAS
GO:0003279
cardiac septum development
TAS
GO:0003337
mesenchymal to epithelial transition involved in metanephros morphogenesis
IDA
GO:0007224
smoothened signaling pathway
IEP
GO:0007281
germ cell development
IEA
GO:0007500
mesodermal cell fate determination
IEA
GO:0008285
negative regulation of cell proliferation
IDA
GO:0009612
response to mechanical stimulus
IEA
GO:0009791
post-embryonic development
IDA
GO:0009948
anterior/posterior axis specification
IEA
GO:0010159
specification of organ position
IEA
GO:0010595
positive regulation of endothelial cell migration
IDA
GO:0010862
positive regulation of pathway-restricted SMAD protein phosphorylation
IDA
GO:0010862
positive regulation of pathway-restricted SMAD protein phosphorylation
IMP
GO:0010942
positive regulation of cell death
IDA
GO:0014070
response to organic cyclic compound
IEA
GO:0021537
telencephalon development
IDA
GO:0021904
dorsal/ventral neural tube patterning
IEA
GO:0021978
telencephalon regionalization
IEA
GO:0021983
pituitary gland development
IEA
GO:0030218
erythrocyte differentiation
IEA
GO:0030501
positive regulation of bone mineralization
IDA
GO:0030509
BMP signaling pathway
IDA
GO:0030509
BMP signaling pathway
IMP
GO:0030513
positive regulation of BMP signaling pathway
ISS
GO:0032331
negative regulation of chondrocyte differentiation
IEA
GO:0032355
response to estradiol stimulus
IEA
GO:0032526
response to retinoic acid
IEA
GO:0032967
positive regulation of collagen biosynthetic process
IDA
GO:0033085
negative regulation of T cell differentiation in thymus
IMP
GO:0033088
negative regulation of immature T cell proliferation in thymus
IMP
GO:0034504
protein localization to nucleus
IDA
GO:0035116
embryonic hindlimb morphogenesis
IEA
GO:0035990
tendon cell differentiation
ISS
GO:0035993
deltoid tuberosity development
ISS
GO:0040007
growth
IEA
GO:0042326
negative regulation of phosphorylation
IDA
GO:0042475
odontogenesis of dentine-containing tooth
IEA
GO:0042476
odontogenesis
IGI
GO:0043065
positive regulation of apoptosis
IDA
GO:0043066
negative regulation of apoptosis
IDA
GO:0043401
steroid hormone mediated signaling pathway
IMP
GO:0043407
negative regulation of MAP kinase activity
IDA
GO:0043587
tongue morphogenesis
IEA
GO:0045603
positive regulation of endothelial cell differentiation
IEA
GO:0045662
negative regulation of myoblast differentiation
IDA
GO:0045666
positive regulation of neuron differentiation
IEA
GO:0045669
positive regulation of osteoblast differentiation
IDA
GO:0045778
positive regulation of ossification
IDA
GO:0045786
negative regulation of cell cycle
IDA
GO:0045839
negative regulation of mitosis
IDA
GO:0045843
negative regulation of striated muscle tissue development
IDA
GO:0045892
negative regulation of transcription, DNA-dependent
IDA
GO:0045893
positive regulation of transcription, DNA-dependent
IDA
GO:0045944
positive regulation of transcription from RNA polymerase II promoter
IDA
GO:0048286
lung alveolus development
IDA
GO:0048392
intermediate mesodermal cell differentiation
IDA
GO:0048593
camera-type eye morphogenesis
IEA
GO:0048598
embryonic morphogenesis
IEA
GO:0048661
positive regulation of smooth muscle cell proliferation
IDA
GO:0048663
neuron fate commitment
IEA
GO:0048701
embryonic cranial skeleton morphogenesis
IEA
GO:0048715
negative regulation of oligodendrocyte differentiation
IEA
GO:0048745
smooth muscle tissue development
ISS
GO:0048754
branching morphogenesis of a tube
IDA
GO:0050680
negative regulation of epithelial cell proliferation
IEA
GO:0050918
positive chemotaxis
IDA
GO:0051150
regulation of smooth muscle cell differentiation
IEA
GO:0051384
response to glucocorticoid stimulus
IEA
GO:0055020
positive regulation of cardiac muscle fiber development
IMP
GO:0060041
retina development in camera-type eye
IEA
GO:0060113
inner ear receptor cell differentiation
IEA
GO:0060197
cloacal septation
IEA
GO:0060235
lens induction in camera-type eye
IEA
GO:0060272
embryonic skeletal joint morphogenesis
IEA
GO:0060363
cranial suture morphogenesis
IEA
GO:0060391
positive regulation of SMAD protein import into nucleus
IDA
GO:0060393
regulation of pathway-restricted SMAD protein phosphorylation
IDA
GO:0060395
SMAD protein signal transduction
IDA
GO:0060425
lung morphogenesis
IDA
GO:0060429
epithelium development
IEA
GO:0060433
bronchus development
IDA
GO:0060438
trachea development
IDA
GO:0060440
trachea formation
IEA
GO:0060441
epithelial tube branching involved in lung morphogenesis
IDA
GO:0060449
bud elongation involved in lung branching
IEA
GO:0060502
epithelial cell proliferation involved in lung morphogenesis
IDA
GO:0060503
bud dilation involved in lung branching
IDA
GO:0060512
prostate gland morphogenesis
IEA
GO:0060548
negative regulation of cell death
IDA
GO:0060592
mammary gland formation
IEA
GO:0060684
epithelial-mesenchymal cell signaling
IEA
GO:0060686
negative regulation of prostatic bud formation
IEA
GO:0060687
regulation of branching involved in prostate gland morphogenesis
IEA
GO:0061036
positive regulation of cartilage development
IDA
GO:0061047
positive regulation of branching involved in lung morphogenesis
ISS
GO:0061149
BMP signaling pathway involved in ureter morphogenesis
ISS
GO:0061151
BMP signaling pathway involved in renal system segmentation
ISS
GO:0061155
pulmonary artery endothelial tube morphogenesis
IDA
GO:0070244
negative regulation of thymocyte apoptosis
IMP
GO:0070374
positive regulation of ERK1 and ERK2 cascade
IEA
GO:0071363
cellular response to growth factor stimulus
IEA
GO:0071549
cellular response to dexamethasone stimulus
IEA
GO:0071893
BMP signaling pathway involved in nephric duct formation
IDA
GO:0072001
renal system development
IEP
GO:0072015
glomerular visceral epithelial cell development
IEA
GO:0072097
negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway
IDA
GO:0072101
specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway
IDA
GO:0072104
glomerular capillary formation
ISS
GO:0072125
negative regulation of glomerular mesangial cell proliferation
IDA
GO:0072138
mesenchymal cell proliferation involved in ureteric bud development
IEA
GO:0072192
ureter epithelial cell differentiation
ISS
GO:0072193
ureter smooth muscle cell differentiation
ISS
GO:0072200
negative regulation of mesenchymal cell proliferation involved in ureter development
IDA
GO:0072205
metanephric collecting duct development
ISS
GO:0090184
positive regulation of kidney development
IDA
GO:0090190
positive regulation of branching involved in ureteric bud morphogenesis
IEA
GO:0090191
negative regulation of branching involved in ureteric bud morphogenesis
IDA
GO:0090194
negative regulation of glomerulus development
IDA
GO:2000005
negative regulation of metanephric S-shaped body morphogenesis
IDA
GO:2000007
negative regulation of metanephric comma-shaped body morphogenesis
IDA
GO:2000137
negative regulation of cell proliferation involved in heart morphogenesis
IMP
cellular_component
GO:0005576
extracellular region
ISS
GO:0005578
proteinaceous extracellular matrix
IEA
GO:0005615
extracellular space
ISS
GO:0005737
cytoplasm
IEA
GO:0031988
membrane-bounded vesicle
IEA
molecular_function
GO:0005125
cytokine activity
IDA
GO:0005515
protein binding
IPI
GO:0008083
growth factor activity
IEA
GO:0008201
heparin binding
IEA
GO:0042056
chemoattractant activity
IDA
GO:0042803
protein homodimerization activity
IEA
GO:0070700
BMP receptor binding
IDA
Protein-protein interaction details for BMP4 (
Homo sapiens
)
(Information is obtained from BioGRID)
Interacting human protein
Experiment
Type
PubMed ID
SOSTDC1
Affinity Capture-Western
physical
15020244
BMPR2
Affinity Capture-Western
physical
7644468
BMPR1A
Reconstituted Complex
physical
8006002
BMPR1B
Reconstituted Complex
physical
8006002
TWSG1
Reconstituted Complex
physical
11260715