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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for BMP4 (Homo sapiens)
(Information is obtained from AmiGO)
IDTermEvidence
biological_process
GO:0000122negative regulation of transcription from RNA polymerase II promoterIDA
GO:0000186activation of MAPKK activityIDA
GO:0001525angiogenesisIEA
GO:0001541ovarian follicle developmentIEA
GO:0001568blood vessel developmentIEA
GO:0001649osteoblast differentiationIDA
GO:0001657ureteric bud developmentIDA
GO:0001658branching involved in ureteric bud morphogenesisIDA
GO:0001759organ inductionIEA
GO:0001822kidney developmentIMP
GO:0001823mesonephros developmentIEP
GO:0001843neural tube closureIEA
GO:0001934positive regulation of protein phosphorylationIDA
GO:0001938positive regulation of endothelial cell proliferationIDA
GO:0001958endochondral ossificationISS
GO:0002043blood vessel endothelial cell proliferation involved in sprouting angiogenesisIDA
GO:0002062chondrocyte differentiationISS
GO:0002244hemopoietic progenitor cell differentiationIDA
GO:0002320lymphoid progenitor cell differentiationIMP
GO:0003014renal system processIEA
GO:0003130BMP signaling pathway involved in heart inductionIMP
GO:0003139secondary heart field specificationIMP
GO:0003197endocardial cushion developmentTAS
GO:0003279cardiac septum developmentTAS
GO:0003337mesenchymal to epithelial transition involved in metanephros morphogenesisIDA
GO:0007224smoothened signaling pathwayIEP
GO:0007281germ cell developmentIEA
GO:0007500mesodermal cell fate determinationIEA
GO:0008285negative regulation of cell proliferationIDA
GO:0009612response to mechanical stimulusIEA
GO:0009791post-embryonic developmentIDA
GO:0009948anterior/posterior axis specificationIEA
GO:0010159specification of organ positionIEA
GO:0010595positive regulation of endothelial cell migrationIDA
GO:0010862positive regulation of pathway-restricted SMAD protein phosphorylationIDA
GO:0010862positive regulation of pathway-restricted SMAD protein phosphorylationIMP
GO:0010942positive regulation of cell deathIDA
GO:0014070response to organic cyclic compoundIEA
GO:0021537telencephalon developmentIDA
GO:0021904dorsal/ventral neural tube patterningIEA
GO:0021978telencephalon regionalizationIEA
GO:0021983pituitary gland developmentIEA
GO:0030218erythrocyte differentiationIEA
GO:0030501positive regulation of bone mineralizationIDA
GO:0030509BMP signaling pathwayIDA
GO:0030509BMP signaling pathwayIMP
GO:0030513positive regulation of BMP signaling pathwayISS
GO:0032331negative regulation of chondrocyte differentiationIEA
GO:0032355response to estradiol stimulusIEA
GO:0032526response to retinoic acidIEA
GO:0032967positive regulation of collagen biosynthetic processIDA
GO:0033085negative regulation of T cell differentiation in thymusIMP
GO:0033088negative regulation of immature T cell proliferation in thymusIMP
GO:0034504protein localization to nucleusIDA
GO:0035116embryonic hindlimb morphogenesisIEA
GO:0035990tendon cell differentiationISS
GO:0035993deltoid tuberosity developmentISS
GO:0040007growthIEA
GO:0042326negative regulation of phosphorylationIDA
GO:0042475odontogenesis of dentine-containing toothIEA
GO:0042476odontogenesisIGI
GO:0043065positive regulation of apoptosisIDA
GO:0043066negative regulation of apoptosisIDA
GO:0043401steroid hormone mediated signaling pathwayIMP
GO:0043407negative regulation of MAP kinase activityIDA
GO:0043587tongue morphogenesisIEA
GO:0045603positive regulation of endothelial cell differentiationIEA
GO:0045662negative regulation of myoblast differentiationIDA
GO:0045666positive regulation of neuron differentiationIEA
GO:0045669positive regulation of osteoblast differentiationIDA
GO:0045778positive regulation of ossificationIDA
GO:0045786negative regulation of cell cycleIDA
GO:0045839negative regulation of mitosisIDA
GO:0045843negative regulation of striated muscle tissue developmentIDA
GO:0045892negative regulation of transcription, DNA-dependentIDA
GO:0045893positive regulation of transcription, DNA-dependentIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0048286lung alveolus developmentIDA
GO:0048392intermediate mesodermal cell differentiationIDA
GO:0048593camera-type eye morphogenesisIEA
GO:0048598embryonic morphogenesisIEA
GO:0048661positive regulation of smooth muscle cell proliferationIDA
GO:0048663neuron fate commitmentIEA
GO:0048701embryonic cranial skeleton morphogenesisIEA
GO:0048715negative regulation of oligodendrocyte differentiationIEA
GO:0048745smooth muscle tissue developmentISS
GO:0048754branching morphogenesis of a tubeIDA
GO:0050680negative regulation of epithelial cell proliferationIEA
GO:0050918positive chemotaxisIDA
GO:0051150regulation of smooth muscle cell differentiationIEA
GO:0051384response to glucocorticoid stimulusIEA
GO:0055020positive regulation of cardiac muscle fiber developmentIMP
GO:0060041retina development in camera-type eyeIEA
GO:0060113inner ear receptor cell differentiationIEA
GO:0060197cloacal septationIEA
GO:0060235lens induction in camera-type eyeIEA
GO:0060272embryonic skeletal joint morphogenesisIEA
GO:0060363cranial suture morphogenesisIEA
GO:0060391positive regulation of SMAD protein import into nucleusIDA
GO:0060393regulation of pathway-restricted SMAD protein phosphorylationIDA
GO:0060395SMAD protein signal transductionIDA
GO:0060425lung morphogenesisIDA
GO:0060429epithelium developmentIEA
GO:0060433bronchus developmentIDA
GO:0060438trachea developmentIDA
GO:0060440trachea formationIEA
GO:0060441epithelial tube branching involved in lung morphogenesisIDA
GO:0060449bud elongation involved in lung branchingIEA
GO:0060502epithelial cell proliferation involved in lung morphogenesisIDA
GO:0060503bud dilation involved in lung branchingIDA
GO:0060512prostate gland morphogenesisIEA
GO:0060548negative regulation of cell deathIDA
GO:0060592mammary gland formationIEA
GO:0060684epithelial-mesenchymal cell signalingIEA
GO:0060686negative regulation of prostatic bud formationIEA
GO:0060687regulation of branching involved in prostate gland morphogenesisIEA
GO:0061036positive regulation of cartilage developmentIDA
GO:0061047positive regulation of branching involved in lung morphogenesisISS
GO:0061149BMP signaling pathway involved in ureter morphogenesisISS
GO:0061151BMP signaling pathway involved in renal system segmentationISS
GO:0061155pulmonary artery endothelial tube morphogenesisIDA
GO:0070244negative regulation of thymocyte apoptosisIMP
GO:0070374positive regulation of ERK1 and ERK2 cascadeIEA
GO:0071363cellular response to growth factor stimulusIEA
GO:0071549cellular response to dexamethasone stimulusIEA
GO:0071893BMP signaling pathway involved in nephric duct formationIDA
GO:0072001renal system developmentIEP
GO:0072015glomerular visceral epithelial cell developmentIEA
GO:0072097negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathwayIDA
GO:0072101specification of ureteric bud anterior/posterior symmetry by BMP signaling pathwayIDA
GO:0072104glomerular capillary formationISS
GO:0072125negative regulation of glomerular mesangial cell proliferationIDA
GO:0072138mesenchymal cell proliferation involved in ureteric bud developmentIEA
GO:0072192ureter epithelial cell differentiationISS
GO:0072193ureter smooth muscle cell differentiationISS
GO:0072200negative regulation of mesenchymal cell proliferation involved in ureter developmentIDA
GO:0072205metanephric collecting duct developmentISS
GO:0090184positive regulation of kidney developmentIDA
GO:0090190positive regulation of branching involved in ureteric bud morphogenesisIEA
GO:0090191negative regulation of branching involved in ureteric bud morphogenesisIDA
GO:0090194negative regulation of glomerulus developmentIDA
GO:2000005negative regulation of metanephric S-shaped body morphogenesisIDA
GO:2000007negative regulation of metanephric comma-shaped body morphogenesisIDA
GO:2000137negative regulation of cell proliferation involved in heart morphogenesisIMP
cellular_component
GO:0005576extracellular regionISS
GO:0005578proteinaceous extracellular matrixIEA
GO:0005615extracellular spaceISS
GO:0005737cytoplasmIEA
GO:0031988membrane-bounded vesicleIEA
molecular_function
GO:0005125cytokine activityIDA
GO:0005515protein bindingIPI
GO:0008083growth factor activityIEA
GO:0008201heparin bindingIEA
GO:0042056chemoattractant activityIDA
GO:0042803protein homodimerization activityIEA
GO:0070700BMP receptor bindingIDA

Protein-protein interaction details for BMP4 (Homo sapiens)
(Information is obtained from BioGRID)
Interacting human proteinExperimentTypePubMed ID
SOSTDC1Affinity Capture-Westernphysical15020244
BMPR2Affinity Capture-Westernphysical7644468
BMPR1AReconstituted Complexphysical8006002
BMPR1BReconstituted Complexphysical8006002
TWSG1Reconstituted Complexphysical11260715