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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for SMO (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA GO:0001570 vasculogenesis IBA GO:0001649 osteoblast differentiation IBA GO:0001701 in utero embryonic development IEA GO:0001708 cell fate specification IEA GO:0001755 neural crest cell migration IBA GO:0001947 heart looping ISS GO:0002052 positive regulation of neuroblast proliferation IBA GO:0002053 positive regulation of mesenchymal cell proliferation IBA GO:0003007 heart morphogenesis IBA GO:0003140 determination of left/right asymmetry in lateral mesoderm ISS GO:0007224 smoothened signaling pathway IEP GO:0007224 smoothened signaling pathway IMP GO:0007228 positive regulation of hh target transcription factor activity ISS GO:0007283 spermatogenesis IBA GO:0007368 determination of left/right symmetry IBA GO:0007371 ventral midline determination ISS GO:0007389 pattern specification process IEA GO:0007494 midgut development ISS GO:0008406 gonad development IBA GO:0009611 response to wounding IEA GO:0010002 cardioblast differentiation IBA GO:0010033 response to organic substance IEA GO:0010628 positive regulation of gene expression ISS GO:0010629 negative regulation of gene expression ISS GO:0021508 floor plate formation IBA GO:0021561 facial nerve development IBA GO:0021696 cerebellar cortex morphogenesis IBA GO:0021904 dorsal/ventral neural tube patterning IBA GO:0021910 smoothened signaling pathway involved in ventral spinal cord patterning IBA GO:0021938 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation IBA GO:0021953 central nervous system neuron differentiation IBA GO:0021984 adenohypophysis development IBA GO:0031017 exocrine pancreas development IBA GO:0031076 embryonic camera-type eye development IBA GO:0031102 neuron projection regeneration IBA GO:0032474 otolith morphogenesis IBA GO:0033687 osteoblast proliferation IEA GO:0034504 protein localization to nucleus IEA GO:0035264 multicellular organism growth IEA GO:0042475 odontogenesis of dentine-containing tooth IBA GO:0042693 muscle cell fate commitment IBA GO:0043066 negative regulation of apoptosis IBA GO:0043392 negative regulation of DNA binding ISS GO:0045880 positive regulation of smoothened signaling pathway IBA GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA GO:0048468 cell development IEA GO:0048557 embryonic digestive tract morphogenesis IBA GO:0048589 developmental growth IEA GO:0048663 neuron fate commitment IBA GO:0048702 embryonic neurocranium morphogenesis IBA GO:0048703 embryonic viscerocranium morphogenesis IBA GO:0048752 semicircular canal morphogenesis IBA GO:0048846 axon extension involved in axon guidance IBA GO:0048853 forebrain morphogenesis ISS GO:0050679 positive regulation of epithelial cell proliferation IBA GO:0050821 protein stabilization IEA GO:0060070 canonical Wnt receptor signaling pathway IBA GO:0060248 detection of cell density by contact stimulus involved in contact inhibition IMP GO:0060684 epithelial-mesenchymal cell signaling IEA GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway IBA GO:0061053 somite development ISS GO:0072001 renal system development IEP GO:0072285 mesenchymal to epithelial transition involved in metanephric renal vesicle formation ISS GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis ISS GO:2000826 regulation of heart morphogenesis ISS cellular_component GO:0005737 cytoplasm IBA GO:0005886 plasma membrane IBA GO:0005886 plasma membrane IDA GO:0005929 cilium IBA GO:0016021 integral to membrane IEA GO:0043025 neuronal cell body IBA molecular_function GO:0004871 signal transducer activity IEA GO:0004872 receptor activity IEA GO:0004930 G-protein coupled receptor activity IEA GO:0005515 protein binding IPI GO:0008144 drug binding IDA GO:0017147 Wnt-protein binding IBA GO:0030165 PDZ domain binding IBA GO:0042813 Wnt-activated receptor activity IBA

Protein-protein interaction details for SMO (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID PTCH1 Affinity Capture-Western physical 9811851 PTCH2 Affinity Capture-Western physical 9811851 BCL6 Affinity Capture-MS physical 16147992