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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for TYK2 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0006468 protein phosphorylation TAS GO:0007243 intracellular protein kinase cascade IEA GO:0019221 cytokine-mediated signaling pathway TAS GO:0060337 type I interferon-mediated signaling pathway TAS GO:0060338 regulation of type I interferon-mediated signaling pathway TAS cellular_component GO:0005634 nucleus IDA GO:0005737 cytoplasm IDA GO:0005829 cytosol TAS GO:0005856 cytoskeleton IEA GO:0016020 membrane IEA molecular_function GO:0000166 nucleotide binding IEA GO:0004713 protein tyrosine kinase activity IEA GO:0004713 protein tyrosine kinase activity TAS GO:0004715 non-membrane spanning protein tyrosine kinase activity IEA GO:0005131 growth hormone receptor binding IPI GO:0005524 ATP binding IEA GO:0016772 transferase activity, transferring phosphorus-containing groups IEA

Protein-protein interaction details for TYK2 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID GNB2L1 Affinity Capture-Western physical 12960323 GNB2L1 Reconstituted Complex physical 12960323 STAT1 Biochemical Activity physical 12960323 PRMT5 Reconstituted Complex physical 10531356 XRCC5 Affinity Capture-Western physical 10673353 XRCC5 Affinity Capture-Western physical 10673353 VAV1 Affinity Capture-Western physical 10673353 IFNAR1 Reconstituted Complex physical 9733772 CRKL Affinity Capture-Western physical 9374471 JAK1 Affinity Capture-Western physical 7589562 TYK2 Affinity Capture-Western physical 7589562 ELP2 Affinity Capture-Western physical 10954736 IL13RA1 Affinity Capture-Western physical 10409622 LYN Reconstituted Complex physical 9633884 CBL Affinity Capture-Western physical 8780698 PTPN6 Affinity Capture-Western physical 7629131 PTPN6 Biochemical Activity physical 7629131 PLAUR Affinity Capture-Western physical 9417082 IL6ST Affinity Capture-Western physical 9388212 FYN Affinity Capture-Western physical 9196040 FYN Reconstituted Complex physical 9196040 PTPN1 Affinity Capture-Western physical 11694501 STAM2 Affinity Capture-Western physical 10899310 GHR Affinity Capture-Western physical 10502458 IRS2 Reconstituted Complex physical 8550573 IFNAR1 Affinity Capture-Western physical 18474601 IFNAR1 Affinity Capture-Western physical 15337770 IFNAR1 Affinity Capture-Western physical 15356134 DNM2 Two-hybrid physical 21900206 TK1 Two-hybrid physical 21900206 SOCS1 Affinity Capture-Western physical 21757742 UBC Affinity Capture-Western physical 21757742 KLF10 Affinity Capture-Western physical 21471442 KLF10 Affinity Capture-Western physical 21471442