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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for VHL (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA GO:0000902 cell morphogenesis NAS GO:0001525 angiogenesis IEA GO:0001666 response to hypoxia IEA GO:0006355 regulation of transcription, DNA-dependent IMP GO:0006508 proteolysis TAS GO:0006916 anti-apoptosis NAS GO:0006950 response to stress NAS GO:0008285 negative regulation of cell proliferation TAS GO:0016567 protein ubiquitination IEA GO:0016567 protein ubiquitination IMP GO:0030163 protein catabolic process IEA GO:0030182 neuron differentiation IEA GO:0030198 extracellular matrix organization IEA GO:0042069 regulation of catecholamine metabolic process IEA GO:0043534 blood vessel endothelial cell migration IEA GO:0045471 response to ethanol IEA GO:0045597 positive regulation of cell differentiation NAS GO:0045893 positive regulation of transcription, DNA-dependent IMP GO:0050821 protein stabilization NAS cellular_component GO:0005634 nucleus IEA GO:0005737 cytoplasm IEA GO:0005739 mitochondrion NAS GO:0005783 endoplasmic reticulum NAS GO:0005829 cytosol IEA GO:0016020 membrane IEA GO:0030891 VCB complex IEA molecular_function GO:0005515 protein binding IPI GO:0008134 transcription factor binding TAS

Protein-protein interaction details for VHL (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID FLNA Two-hybrid physical 8674032 FLNA Two-hybrid physical 12169691 VBP1 Two-hybrid physical 8674032 PHF17 Two-hybrid physical 12169691 CUL2 Affinity Capture-MS physical 17353931 CAB39 Affinity Capture-MS physical 17353931 TGFB1I1 Affinity Capture-MS physical 17353931 STK16 Affinity Capture-MS physical 17353931 PFAS Affinity Capture-MS physical 17353931 TCEB1 Affinity Capture-MS physical 17353931 PSMB1 Affinity Capture-MS physical 17353931 TCEB2 Affinity Capture-MS physical 17353931 RHOC Affinity Capture-MS physical 17353931 CNTF Affinity Capture-MS physical 17353931 TXN Affinity Capture-MS physical 17353931 APRT Affinity Capture-MS physical 17353931 CDK2 Affinity Capture-MS physical 17353931 PKD1L3 Affinity Capture-MS physical 17353931 FSCN1 Affinity Capture-MS physical 17353931 IARS Affinity Capture-MS physical 17353931 PSMB3 Affinity Capture-MS physical 17353931 RASGRP1 Affinity Capture-MS physical 17353931 RAB1B Affinity Capture-MS physical 17353931 RBX1 Affinity Capture-MS physical 17353931 NEDD8 Affinity Capture-MS physical 17353931 TAGLN2 Affinity Capture-MS physical 17353931 MOBKL3 Affinity Capture-MS physical 17353931 CCDC59 Affinity Capture-MS physical 17353931 JMJD1C Affinity Capture-MS physical 17353931 CDO1 Affinity Capture-MS physical 17353931 PAPSS2 Affinity Capture-MS physical 17353931 HIST1H2BC Affinity Capture-MS physical 17353931 CCDC82 Affinity Capture-MS physical 17353931 PSMD13 Affinity Capture-MS physical 17353931 TARS Affinity Capture-MS physical 17353931 TPT1 Affinity Capture-MS physical 17353931 RPA3 Affinity Capture-MS physical 17353931 KNTC1 Affinity Capture-MS physical 17353931 MCC Affinity Capture-MS physical 17353931 PCMT1 Affinity Capture-MS physical 17353931 CSTB Affinity Capture-MS physical 17353931 CSTF3 Affinity Capture-MS physical 17353931 HAS1 Affinity Capture-MS physical 17353931 RPS9 Affinity Capture-MS physical 17353931 IMPDH2 Affinity Capture-MS physical 17353931 ATXN2 Affinity Capture-MS physical 17353931 CHMP2B Affinity Capture-MS physical 17353931 MYL12A Affinity Capture-MS physical 17353931 PPIB Affinity Capture-MS physical 17353931 PIN1 Affinity Capture-MS physical 17353931 PSMC3 Two-hybrid physical 14556007 PSMC3 Affinity Capture-Western physical 14556007 PSMC3 Affinity Capture-Western physical 14556007 HIF1A Affinity Capture-Western physical 14556007 ZNF197 Two-hybrid physical 12682018 ZNF197 Reconstituted Complex physical 12682018 ZNF197 Affinity Capture-Western physical 12682018 HIF1A Affinity Capture-Western physical 12682018 TRIM28 Reconstituted Complex physical 12682018 HIF1AN Reconstituted Complex physical 11641274 HIF1A Reconstituted Complex physical 11641274 HIF1AN Reconstituted Complex physical 11641274 HDAC1 Reconstituted Complex physical 11641274 HDAC2 Reconstituted Complex physical 11641274 HDAC3 Reconstituted Complex physical 11641274 TCEB1 Reconstituted Complex physical 10587522 TCEB2 Reconstituted Complex physical 10587522 CUL2 Affinity Capture-Western physical 10587522 TCEB2 Affinity Capture-Western physical 10587522 FN1 Affinity Capture-Western physical 9651579 PHF17 Affinity Capture-Western physical 12169691 VBP1 Two-hybrid physical 12169691 TCEB1 Two-hybrid physical 8674032 VBP1 Affinity Capture-Western physical 8674032 HIF1A Reconstituted Complex physical 10944113 CUL2 Reconstituted Complex physical 11384984 CUL5 Reconstituted Complex physical 11384984 TCEB1 Co-crystal Structure physical 12004076 TCEB2 Co-crystal Structure physical 12004076 HIF1A Co-crystal Structure physical 12004076 HNRNPA2B1 Affinity Capture-Western physical 11517223 HIF1A Reconstituted Complex physical 11504942 HIF1A Affinity Capture-Western physical 11504942 USP33 Two-hybrid physical 11739384 USP33 Reconstituted Complex physical 11739384 USP33 Affinity Capture-Western physical 11739384 TCEB1 Reconstituted Complex physical 11739384 TCEB1 Affinity Capture-Western physical 19030229 TCEB2 Affinity Capture-Western physical 19030229 CUL2 Affinity Capture-Western physical 19030229 RIT1 Affinity Capture-Western physical 19030229 CUL2 Affinity Capture-Western physical 19030229 HIF1A Affinity Capture-Western physical 18985005 HIF1A Affinity Capture-Western physical 18985005 HIF1A Affinity Capture-Western physical 18694926 HIF1A Reconstituted Complex physical 18426857 NR4A1 Affinity Capture-Western physical 18305400 NR4A1 Affinity Capture-Western physical 18305400 NR4A1 Reconstituted Complex physical 18305400 HIF1A Reconstituted Complex physical 18305400 TCEB1 Affinity Capture-Western physical 18305400 POLR2A Affinity Capture-Western physical 18285459 SAP130 Affinity Capture-Western physical 18173839 CUL2 Affinity Capture-Western physical 18173839 TCEB2 Affinity Capture-Western physical 18173839 SAP130 Affinity Capture-Western physical 18173839 HIF1A Affinity Capture-Western physical 17981124 HIF1A Reconstituted Complex physical 17981124 HIF1A Affinity Capture-Western physical 17973296 EPAS1 Affinity Capture-Western physical 17967880 OSR1 Affinity Capture-Western physical 16511565 DGKZ Co-localization physical 17350623 DGKZ Affinity Capture-Western physical 17350623 DGKZ Affinity Capture-Western physical 17350623 HIF1A Reconstituted Complex physical 17558023 HIF1A Reconstituted Complex physical 17558023 TCEB1 Reconstituted Complex physical 17558023 HIF1A Affinity Capture-Western physical 17558023 TCEB1 Affinity Capture-Western physical 17558023 SAT2 Reconstituted Complex physical 17558023 CUL2 Affinity Capture-Western physical 17439941 CYBA Affinity Capture-Western physical 17200123 PHF17 Affinity Capture-Western physical 14973063 PHF17 Reconstituted Complex physical 14973063 HIF1A Affinity Capture-Western physical 17047048 HIF1A Affinity Capture-Western physical 16611863 CUL2 Affinity Capture-Western physical 16611863 RBX1 Affinity Capture-Western physical 16325183 HIF1A Affinity Capture-Western physical 16278378 CUL2 Affinity Capture-Western physical 15966899 DNAJA3 Reconstituted Complex physical 15805242 DNAJA3 Affinity Capture-Western physical 15805242 HIF1A Affinity Capture-Western physical 15805242 IREB2 Affinity Capture-Western physical 15777842 HIF1A Reconstituted Complex physical 15721254 TP53 Affinity Capture-Western physical 16678111 TP53 Reconstituted Complex physical 16678111 TP53 Affinity Capture-Western physical 16678111 EP300 Affinity Capture-Western physical 16678111 KAT2B Affinity Capture-Western physical 16678111 ATM Affinity Capture-Western physical 16678111 USP20 Affinity Capture-Western physical 12056827 USP20 Two-hybrid physical 12056827 USP20 Reconstituted Complex physical 12056827 USP20 Biochemical Activity physical 12056827 HIF1A Co-crystal Structure physical 12050673 HIF1A Reconstituted Complex physical 12050673 CUL2 Affinity Capture-Western physical 12048197 RBX1 Affinity Capture-Western physical 12048197 TCEB3 Affinity Capture-Western physical 12048197 TCEB2 Affinity Capture-Western physical 12048197 TCEB2 Affinity Capture-Western physical 12048197 HIF1A Affinity Capture-Western physical 14691445 HIF1A Affinity Capture-Western physical 14600153 HIF1A Affinity Capture-Western physical 12925778 HIF1A Protein-peptide physical 12925778 POLR2G Two-hybrid physical 12912922 POLR2G Reconstituted Complex physical 12912922 POLR2G Affinity Capture-Western physical 12912922 HIF1A Affinity Capture-Western physical 12808024 HIF1A Reconstituted Complex physical 12606543 POLR2A Protein-peptide physical 12604794 POLR2A Affinity Capture-Western physical 12604794 EPAS1 Affinity Capture-Western physical 12604794 CUL2 Affinity Capture-Western physical 12604794 TCEB2 Affinity Capture-Western physical 12604794 TCEB1 Affinity Capture-Western physical 12604794 RBX1 Affinity Capture-Western physical 12604794 HIF3A Reconstituted Complex physical 12538644 HIF1A Reconstituted Complex physical 12538644 HIF3A Affinity Capture-Western physical 12538644 HIF1A Affinity Capture-Western physical 12464182 HIF1A Reconstituted Complex physical 18264140 CCT3 Affinity Capture-Western physical 11865071 CUL2 Affinity Capture-Western physical 11865071 HIF1A Affinity Capture-Western physical 11865071 HIF1A Protein-peptide physical 11566883 HIF1A Biochemical Activity physical 11566883 HIF1A Affinity Capture-Western physical 11331613 EPAS1 Affinity Capture-Western physical 11331613 HIF1A Affinity Capture-Western physical 11292861 HIF1A Reconstituted Complex physical 11292861 HIF1A Biochemical Activity physical 10973499 HIF1A Affinity Capture-Western physical 10973499 HIF1A Affinity Capture-Western physical 10973499 HIF1A Reconstituted Complex physical 10878807 HIF1A Reconstituted Complex physical 10878807 EPAS1 Affinity Capture-Western physical 10878807 HIF1A Affinity Capture-Western physical 10823831 EPAS1 Affinity Capture-Western physical 10823831 CUL2 Affinity Capture-Western physical 10823831 TCEB2 Affinity Capture-Western physical 10823831 TCEB1 Affinity Capture-Western physical 10823831 HIF1A Reconstituted Complex physical 10823831 EPAS1 Reconstituted Complex physical 10823831 UBC Reconstituted Complex physical 10421634 UBC Affinity Capture-Western physical 10421634 CUL2 Reconstituted Complex physical 10421634 TCEB1 Reconstituted Complex physical 10421634 CUL2 Affinity Capture-Western physical 10421634 MCM7 Reconstituted Complex physical 21658608 MCM7 Affinity Capture-Western physical 21658608 PRKCI Biochemical Activity physical 11574546 DVL2 Biochemical Activity physical 20639871 MYBBP1A Far Western physical 21386990 MYBBP1A Affinity Capture-MS physical 21386990 CUL2 Affinity Capture-Western physical 17132228 HIF1A Affinity Capture-Western physical 17132228 HIF1A Affinity Capture-Western physical 21332579 HIF1A Affinity Capture-Western physical 20049704 CUL2 Affinity Capture-Western physical 20049704 TCEB2 Affinity Capture-Western physical 20049704 UBC Affinity Capture-Western physical 20844582 HIF1A Affinity Capture-Western physical 20724477 NEDD8 Affinity Capture-Western physical 15060148 NEDD8 Affinity Capture-Western physical 15060148 CUL2 Affinity Capture-Western physical 15060148 HIF1A Biochemical Activity physical 15060148 TCEB1 Affinity Capture-Western physical 15060148 TCEB2 Affinity Capture-Western physical 15060148 FN1 Affinity Capture-Western physical 15060148 UBXN7 Affinity Capture-MS physical 18775313 HIF1A Affinity Capture-MS physical 19940151 ADRB2 Affinity Capture-Western physical 19584355 SPRY2 Affinity Capture-Western physical 22006925 HIF1A Reconstituted Complex physical 21335603 ANKRD40 Affinity Capture-MS physical 21942715 CDKN2A Affinity Capture-MS physical 21942715 STUB1 Affinity Capture-MS physical 21942715 C16orf61 Affinity Capture-MS physical 21942715 CUL2 Affinity Capture-MS physical 21942715 DDX17 Affinity Capture-MS physical 21942715 DDX3X Affinity Capture-MS physical 21942715 DDX3Y Affinity Capture-MS physical 21942715 DDX5 Affinity Capture-MS physical 21942715 DNAJA1 Affinity Capture-MS physical 21942715 DNAJA2 Affinity Capture-MS physical 21942715 DNAJA3 Affinity Capture-MS physical 21942715 TCEB2 Affinity Capture-MS physical 21942715 TCEB1 Affinity Capture-MS physical 21942715 EPHA4 Affinity Capture-MS physical 21942715 GRWD1 Affinity Capture-MS physical 21942715 GLT25D1 Affinity Capture-MS physical 21942715 HNRPDL Affinity Capture-MS physical 21942715 HNRNPH1 Affinity Capture-MS physical 21942715 HNRNPH2 Affinity Capture-MS physical 21942715 HNRPLL Affinity Capture-MS physical 21942715 HNRNPC Affinity Capture-MS physical 21942715 HNRNPD Affinity Capture-MS physical 21942715 HNRNPL Affinity Capture-MS physical 21942715 HNRNPM Affinity Capture-MS physical 21942715 HNRNPR Affinity Capture-MS physical 21942715 EIF5A Affinity Capture-MS physical 21942715 EIF5A2 Affinity Capture-MS physical 21942715 NKRF Affinity Capture-MS physical 21942715 TP53 Affinity Capture-MS physical 21942715 RALYL Affinity Capture-MS physical 21942715 RBBP4 Affinity Capture-MS physical 21942715 RBBP7 Affinity Capture-MS physical 21942715 RPL12 Affinity Capture-MS physical 21942715 RPL14 Affinity Capture-MS physical 21942715 RPL18A Affinity Capture-MS physical 21942715 HNRNPA2B1 Affinity Capture-MS physical 21942715 HNRNPA3 Affinity Capture-MS physical 21942715 RPS11 Affinity Capture-MS physical 21942715 RPS14 Affinity Capture-MS physical 21942715 RPS17 Affinity Capture-MS physical 21942715 RPS27L Affinity Capture-MS physical 21942715 RPS27 Affinity Capture-MS physical 21942715 RPS2 Affinity Capture-MS physical 21942715 RPS3A Affinity Capture-MS physical 21942715 RPS3 Affinity Capture-MS physical 21942715 RPSA Affinity Capture-MS physical 21942715 SNRNP70 Affinity Capture-MS physical 21942715 TUBA1A Affinity Capture-MS physical 21942715 TUBA3C Affinity Capture-MS physical 21942715 TUBA3E Affinity Capture-MS physical 21942715 TUBA4A Affinity Capture-MS physical 21942715 TCP1 Affinity Capture-MS physical 21942715 CCT2 Affinity Capture-MS physical 21942715 CCT4 Affinity Capture-MS physical 21942715 CCT5 Affinity Capture-MS physical 21942715 CCT3 Affinity Capture-MS physical 21942715 CCT7 Affinity Capture-MS physical 21942715 CCT8 Affinity Capture-MS physical 21942715 CCT6A Affinity Capture-MS physical 21942715 TRAFD1 Affinity Capture-MS physical 21942715 UBR5 Affinity Capture-MS physical 21942715 CDKN2A Affinity Capture-Western physical 21942715 PRMT3 Affinity Capture-Western physical 21942715 TP53 Affinity Capture-Western physical 21942715 ACTB Affinity Capture-MS physical 21942715 BSG Affinity Capture-MS physical 21942715 COL4A1 Affinity Capture-MS physical 21942715 COL4A2 Affinity Capture-MS physical 21942715 COL4A3 Affinity Capture-MS physical 21942715 COL4A5 Affinity Capture-MS physical 21942715 COL4A6 Affinity Capture-MS physical 21942715 COL6A1 Affinity Capture-MS physical 21942715 CRTAP Affinity Capture-MS physical 21942715 FASTKD3 Affinity Capture-MS physical 21942715 FN1 Affinity Capture-MS physical 21942715 GRN Affinity Capture-MS physical 21942715 HNRNPK Affinity Capture-MS physical 21942715 HNRNPU Affinity Capture-MS physical 21942715 HSPA8 Affinity Capture-MS physical 21942715 MIF Affinity Capture-MS physical 21942715 IVNS1ABP Affinity Capture-MS physical 21942715 LEPRE1 Affinity Capture-MS physical 21942715 PARP1 Affinity Capture-MS physical 21942715 PLOD2 Affinity Capture-MS physical 21942715 PLOD3 Affinity Capture-MS physical 21942715 PPM1B Affinity Capture-MS physical 21942715 RPL10A Affinity Capture-MS physical 21942715 RPL30 Affinity Capture-MS physical 21942715 RPL7A Affinity Capture-MS physical 21942715 RPLP0 Affinity Capture-MS physical 21942715 HNRNPA1 Affinity Capture-MS physical 21942715 HNRNPAB Affinity Capture-MS physical 21942715 RPS15A Affinity Capture-MS physical 21942715 RPS5 Affinity Capture-MS physical 21942715 STK38 Affinity Capture-MS physical 21942715 TUBA3D Affinity Capture-MS physical 21942715 TUBB2C Affinity Capture-MS physical 21942715 VHL Affinity Capture-MS physical 21942715 XRCC5 Affinity Capture-MS physical 21942715 SKP2 Affinity Capture-Western physical 21358672 SKP2 Affinity Capture-Western physical 21358672 SKP2 Reconstituted Complex physical 21358672 HIF1A Reconstituted Complex physical 21358672