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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for CUL3 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000082 G1/S transition of mitotic cell cycle TAS GO:0000090 mitotic anaphase IMP GO:0000902 cell morphogenesis IEA GO:0000910 cytokinesis IMP GO:0001701 in utero embryonic development IEA GO:0001831 trophectodermal cellular morphogenesis IEA GO:0007050 cell cycle arrest TAS GO:0007369 gastrulation IEA GO:0008054 cyclin catabolic process IDA GO:0008284 positive regulation of cell proliferation TAS GO:0008629 induction of apoptosis by intracellular signals TAS GO:0016055 Wnt receptor signaling pathway IEA GO:0016477 cell migration IMP GO:0016567 protein ubiquitination IDA GO:0035024 negative regulation of Rho protein signal transduction IMP GO:0043149 stress fiber assembly IMP GO:0043161 proteasomal ubiquitin-dependent protein catabolic process IDA GO:0051322 anaphase IMP cellular_component GO:0005634 nucleus IEA GO:0005794 Golgi apparatus IEA GO:0005827 polar microtubule IDA GO:0031463 Cul3-RING ubiquitin ligase complex IDA molecular_function GO:0004842 ubiquitin-protein ligase activity IDA GO:0005515 protein binding IPI GO:0030332 cyclin binding IEA GO:0031625 ubiquitin protein ligase binding IEA

Protein-protein interaction details for CUL3 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID CCNE1 Two-hybrid physical 10500095 CAND1 Affinity Capture-Western physical 12609982 CAND1 Affinity Capture-MS physical 12609982 CCNE1 Affinity Capture-Western physical 10500095 CCNE1 Affinity Capture-Western physical 10500095 RBX1 Affinity Capture-MS physical 12481031 DCUN1D1 Reconstituted Complex physical 18826954 DCUN1D1 Affinity Capture-Western physical 18826954 KCTD5 Affinity Capture-Western physical 18573101 KCTD5 Reconstituted Complex physical 18573101 ABTB2 Reconstituted Complex physical 18429817 ABTB2 Affinity Capture-Western physical 18429817 ABTB2 Affinity Capture-Western physical 18429817 DNTT Affinity Capture-Western physical 18429817 DNTT Affinity Capture-Western physical 18429817 KEAP1 Affinity Capture-Western physical 18417180 KLHL12 Affinity Capture-Western physical 18303015 KLHL12 Affinity Capture-Western physical 18303015 ARHGDIB Affinity Capture-Western physical 18303015 KEAP1 Affinity Capture-Western physical 18251510 KEAP1 Reconstituted Complex physical 18251510 KEAP1 Affinity Capture-Western physical 17822677 COPS5 Affinity Capture-MS physical 19615732 COPS6 Affinity Capture-MS physical 19615732 KEAP1 Affinity Capture-Western physical 17439941 KEAP1 Affinity Capture-Western physical 17439941 CUL3 FRET physical 17192413 CUL3 Affinity Capture-Western physical 17192413 NEDD8 Affinity Capture-Western physical 17192413 CCNE1 Affinity Capture-Western physical 17192413 PMS1 Affinity Capture-Western physical 17148452 PGAM5 Affinity Capture-Western physical 17046835 KCTD11 Affinity Capture-Western physical 20081843 KCTD11 Biochemical Activity physical 20081843 SUMO2 Affinity Capture-MS physical 16620772 SUMO3 Affinity Capture-MS physical 16620772 NEDD8 Affinity Capture-MS physical 16620772 GABARAPL1 Affinity Capture-MS physical 20562859 GABARAPL2 Affinity Capture-MS physical 20562859 KBTBD7 Affinity Capture-MS physical 20562859 COPS3 Affinity Capture-MS physical 16036220 KEAP1 Affinity Capture-Western physical 15983046 GAN Affinity Capture-Western physical 15983046 ENC1 Affinity Capture-Western physical 15983046 KBTBD10 Affinity Capture-Western physical 15983046 KEAP1 Affinity Capture-Western physical 15601839 KEAP1 Reconstituted Complex physical 15601839 NFE2L2 Affinity Capture-Western physical 15601839 KEAP1 Affinity Capture-Western physical 15601839 RBX1 Affinity Capture-Western physical 15601839 KEAP1 Affinity Capture-Western physical 15572695 RBX1 Affinity Capture-MS physical 15448697 KEAP1 Affinity Capture-Western physical 15367669 NFE2L2 Affinity Capture-Western physical 15367669 NFE2L2 Affinity Capture-Western physical 15367669 KEAP1 Affinity Capture-Western physical 15282312 KEAP1 Affinity Capture-Western physical 15282312 KLHL12 Affinity Capture-Western physical 16547521 BMI1 Affinity Capture-Western physical 15897469 H2AFY Affinity Capture-Western physical 15897469 RBX1 Affinity Capture-Western physical 11861641 KLHL20 Affinity Capture-Western physical 20389280 DAPK1 Affinity Capture-Western physical 20389280 KEAP1 Affinity Capture-Western physical 16790436 ARHGEF12 Two-hybrid physical 21670212 ARHGEF12 Affinity Capture-Western physical 21670212 ARHGEF12 Reconstituted Complex physical 21670212 ARHGEF12 Biochemical Activity physical 21670212 COMMD1 Affinity Capture-Western physical 21778237 COMMD1 Reconstituted Complex physical 21778237 COMMD1 Reconstituted Complex physical 21778237 NFE2L2 Affinity Capture-Western physical 16785233 DNMT3B Affinity Capture-Western physical 20847044 SPOP Reconstituted Complex physical 21577200 RBX1 Affinity Capture-Western physical 20027226 KEAP1 Affinity Capture-Western physical 20027226 RBX1 Affinity Capture-Western physical 20027226 NCOA3 Biochemical Activity physical 21577200 IKBKB Affinity Capture-Western physical 19818716 KEAP1 Affinity Capture-Western physical 19818716 RBX1 Affinity Capture-Western physical 19818716 KCTD11 Affinity Capture-Western physical 21237243 KEAP1 Affinity Capture-Western physical 20865015 KEAP1 Affinity Capture-Western physical 20865015 RBX1 Affinity Capture-Western physical 20865015 BCL2 Affinity Capture-Western physical 20865015 RBX1 Affinity Capture-Western physical 20865015 KLHDC5 Two-hybrid physical 19261606 PDIA2 Two-hybrid physical 19261606 SPOP Two-hybrid physical 19261606 KATNA1 Affinity Capture-Western physical 19261606 KATNA1 Affinity Capture-Western physical 19261606 KLHDC5 Affinity Capture-Western physical 19261606 KEAP1 Reconstituted Complex physical 20599909 KEAP1 Affinity Capture-Western physical 20599909 RHOA Affinity Capture-Western physical 19782033 RHOA Biochemical Activity physical 19782033 KLHL21 Affinity Capture-Western physical 19995937 KLHL9 Affinity Capture-Western physical 19995937 KLHL13 Affinity Capture-Western physical 19995937 KLHL21 Affinity Capture-Western physical 19995937 NSFL1C Affinity Capture-Western physical 18775313 FAF2 Affinity Capture-Western physical 18775313 FAF1 Affinity Capture-Western physical 18775313 UBXN7 Affinity Capture-Western physical 18775313 UBXN1 Affinity Capture-Western physical 18775313 UBXN7 Affinity Capture-MS physical 18775313 NEDD8 Affinity Capture-MS physical 18274552 FAF1 Affinity Capture-MS physical 18775313 UBXN1 Affinity Capture-MS physical 18775313 HSF2 Two-hybrid physical 19768582 HSF2 Two-hybrid physical 19768582 HSF2 Reconstituted Complex physical 19768582 HSF2 Affinity Capture-Western physical 19768582 KEAP1 Affinity Capture-Western physical 20864537 KEAP1 Co-localization physical 20421418 SQSTM1 Co-localization physical 20421418 KEAP1 Affinity Capture-Western physical 20421418 NCOA3 Affinity Capture-Western physical 22147914 UBC Affinity Capture-MS physical 22118674 NFE2L2 Biochemical Activity physical 22215675 KEAP1 Affinity Capture-Western physical 20534351 CAND1 Affinity Capture-MS physical 21249194 CAND1 Affinity Capture-Western physical 21249194 UBC Affinity Capture-MS physical 21987572