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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for TP63 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA GO:0001501 skeletal system development IEA GO:0001736 establishment of planar polarity IEA GO:0002053 positive regulation of mesenchymal cell proliferation IEA GO:0002064 epithelial cell development IEA GO:0006351 transcription, DNA-dependent IBA GO:0006915 apoptosis IDA GO:0006915 apoptosis IEA GO:0006916 anti-apoptosis IBA GO:0006917 induction of apoptosis IEA GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IBA GO:0007389 pattern specification process IEA GO:0007499 ectoderm and mesoderm interaction IEA GO:0007569 cell aging IEA GO:0009887 organ morphogenesis IEA GO:0009954 proximal/distal pattern formation IEA GO:0010165 response to X-ray IBA GO:0010259 multicellular organismal aging IEA GO:0010332 response to gamma radiation IBA GO:0030326 embryonic limb morphogenesis IEA GO:0030850 prostate gland development IEA GO:0030859 polarized epithelial cell differentiation IEA GO:0031069 hair follicle morphogenesis IEA GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint IBA GO:0034644 cellular response to UV IBA GO:0035121 tail morphogenesis IEA GO:0042475 odontogenesis of dentine-containing tooth IEA GO:0042771 DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis IBA GO:0043523 regulation of neuron apoptosis IBA GO:0043589 skin morphogenesis IEA GO:0043616 keratinocyte proliferation IEA GO:0045617 negative regulation of keratinocyte differentiation IEA GO:0045747 positive regulation of Notch signaling pathway IDA GO:0045892 negative regulation of transcription, DNA-dependent IDA GO:0045893 positive regulation of transcription, DNA-dependent IDA GO:0045893 positive regulation of transcription, DNA-dependent NAS GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA GO:0048485 sympathetic nervous system development IEA GO:0048646 anatomical structure formation involved in morphogenesis IEA GO:0048745 smooth muscle tissue development IEA GO:0048807 female genitalia morphogenesis IEA GO:0051289 protein homotetramerization IPI GO:0060157 urinary bladder development IEA GO:0060197 cloacal septation IEA GO:0060513 prostatic bud formation IEA GO:0060529 squamous basal epithelial stem cell differentiation involved in prostate gland acinus development IEA cellular_component GO:0000785 chromatin IBA GO:0005634 nucleus IDA GO:0005634 nucleus IEA GO:0005634 nucleus NAS GO:0005667 transcription factor complex IBA GO:0005730 nucleolus IDA GO:0005737 cytoplasm IDA GO:0005794 Golgi apparatus IDA GO:0005829 cytosol IBA GO:0030425 dendrite IBA molecular_function GO:0002039 p53 binding IBA GO:0003677 DNA binding IEA GO:0003677 DNA binding NAS GO:0003682 chromatin binding IBA GO:0003684 damaged DNA binding IBA GO:0003690 double-stranded DNA binding IBA GO:0003700 sequence-specific DNA binding transcription factor activity IBA GO:0003700 sequence-specific DNA binding transcription factor activity IEA GO:0005515 protein binding IPI GO:0042802 identical protein binding IPI GO:0043565 sequence-specific DNA binding IBA GO:0044212 transcription regulatory region DNA binding IEA GO:0046872 metal ion binding IEA

Protein-protein interaction details for TP63 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID HNRNPAB Two-hybrid physical 12692135 GNB2L1 Two-hybrid physical 12692135 HNRNPAB Two-hybrid physical 12692135 SFRS15 Two-hybrid physical 12692135 HNRNPAB Reconstituted Complex physical 12692135 YAP1 Reconstituted Complex physical 11278685 HIPK2 Two-hybrid physical 11925430 BTRC Affinity Capture-Western physical 17965458 BTRC Affinity Capture-Western physical 17965458 BTRC Reconstituted Complex physical 17965458 UBC Affinity Capture-Western physical 17965458 BTRC Biochemical Activity physical 17965458 ADH5 Affinity Capture-Western physical 20308539 AGBL2 Affinity Capture-Western physical 20308539 ASPM Affinity Capture-Western physical 20308539 BRD8 Affinity Capture-Western physical 20308539 NPRL3 Affinity Capture-Western physical 20308539 C4orf41 Affinity Capture-Western physical 20308539 CDT1 Affinity Capture-Western physical 20308539 DAB2IP Affinity Capture-Western physical 20308539 DDX23 Affinity Capture-Western physical 20308539 DNAJB6 Affinity Capture-Western physical 20308539 DPH1 Affinity Capture-Western physical 20308539 EIF2C1 Affinity Capture-Western physical 20308539 EIF2C2 Affinity Capture-Western physical 20308539 GAS8 Affinity Capture-Western physical 20308539 IGF2BP1 Affinity Capture-Western physical 20308539 LOC613037 Affinity Capture-Western physical 20308539 JPH1 Affinity Capture-Western physical 20308539 MTHFSD Affinity Capture-Western physical 20308539 MYL9 Affinity Capture-Western physical 20308539 N4BP2 Affinity Capture-Western physical 20308539 PIWIL1 Affinity Capture-Western physical 20308539 RNF38 Affinity Capture-Western physical 20308539 SMARCD2 Affinity Capture-Western physical 20308539 TRMT11 Affinity Capture-Western physical 20308539 UBC Affinity Capture-Western physical 15846104 EMX1 Two-hybrid physical 20211142 ITCH Affinity Capture-Western physical 16908849 UBC Affinity Capture-Western physical 16908849 MDM2 Reconstituted Complex physical 21088494 MDM4 Reconstituted Complex physical 21088494 MDM2 Reconstituted Complex physical 21088494 MDM4 Reconstituted Complex physical 21088494 WWP1 Affinity Capture-Western physical 20951678 WWP1 Biochemical Activity physical 20951678 RELA Affinity Capture-Western physical 22020940 RELA Affinity Capture-Western physical 22020940