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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for RIPK2 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000187 activation of MAPK activity TAS GO:0001961 positive regulation of cytokine-mediated signaling pathway IEA GO:0002218 activation of innate immune response TAS GO:0002224 toll-like receptor signaling pathway TAS GO:0002250 adaptive immune response ISS GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS GO:0002827 positive regulation of T-helper 1 type immune response IEA GO:0006915 apoptosis TAS GO:0006916 anti-apoptosis TAS GO:0006954 inflammatory response TAS GO:0007165 signal transduction TAS GO:0007249 I-kappaB kinase/NF-kappaB cascade ISS GO:0007254 JNK cascade TAS GO:0008063 Toll signaling pathway TAS GO:0031398 positive regulation of protein ubiquitination IMP GO:0031663 lipopolysaccharide-mediated signaling pathway IEA GO:0032722 positive regulation of chemokine production IEA GO:0032729 positive regulation of interferon-gamma production IEA GO:0032743 positive regulation of interleukin-2 production IEA GO:0032755 positive regulation of interleukin-6 production IEA GO:0032760 positive regulation of tumor necrosis factor production IEA GO:0032874 positive regulation of stress-activated MAPK cascade IEA GO:0033091 positive regulation of immature T cell proliferation IEA GO:0034130 toll-like receptor 1 signaling pathway TAS GO:0034134 toll-like receptor 2 signaling pathway IDA GO:0034134 toll-like receptor 2 signaling pathway TAS GO:0034138 toll-like receptor 3 signaling pathway TAS GO:0034142 toll-like receptor 4 signaling pathway TAS GO:0042098 T cell proliferation IEA GO:0043065 positive regulation of apoptosis IEA GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade IDA GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade IEP GO:0043330 response to exogenous dsRNA IEA GO:0045087 innate immune response ISS GO:0045087 innate immune response TAS GO:0045627 positive regulation of T-helper 1 cell differentiation IEA GO:0046330 positive regulation of JNK cascade IEA GO:0046641 positive regulation of alpha-beta T cell proliferation IEA GO:0048011 nerve growth factor receptor signaling pathway TAS GO:0050830 defense response to Gram-positive bacterium IEA GO:0050852 T cell receptor signaling pathway ISS GO:0050852 T cell receptor signaling pathway TAS GO:0051092 positive regulation of NF-kappaB transcription factor activity TAS GO:0051403 stress-activated MAPK cascade TAS GO:0070374 positive regulation of ERK1 and ERK2 cascade IEA GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway TAS GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway IEA GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway IEA GO:0070555 response to interleukin-1 IEA GO:0070671 response to interleukin-12 IEA GO:0070673 response to interleukin-18 IEA GO:0071223 cellular response to lipoteichoic acid IEA GO:0071224 cellular response to peptidoglycan IEA cellular_component GO:0005622 intracellular IEA GO:0005737 cytoplasm IEA GO:0005829 cytosol TAS molecular_function GO:0000166 nucleotide binding IEA GO:0004674 protein serine/threonine kinase activity IEA GO:0004715 non-membrane spanning protein tyrosine kinase activity IEA GO:0004871 signal transducer activity TAS GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0030274 LIM domain binding IPI GO:0042803 protein homodimerization activity IDA GO:0050700 CARD domain binding IDA GO:0050700 CARD domain binding IPI

Protein-protein interaction details for RIPK2 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID UBE2I Two-hybrid physical 16189514 KCTD12 Affinity Capture-MS physical 17353931 PHB2 Affinity Capture-MS physical 17353931 RPS14 Affinity Capture-MS physical 17353931 RPL38 Affinity Capture-MS physical 17353931 CARD6 Affinity Capture-Western physical 12775719 CFLAR Affinity Capture-Western physical 9575181 TRAF5 Affinity Capture-Western physical 9642260 TRAF6 Affinity Capture-Western physical 9642260 BIRC2 Affinity Capture-Western physical 9642260 TNFRSF1A Affinity Capture-Western physical 9642260 CD40 Affinity Capture-Western physical 9642260 COP Affinity Capture-Western physical 11432859 TRAF1 Affinity Capture-Western physical 9705938 TRAF2 Affinity Capture-Western physical 9705938 BIRC2 Affinity Capture-Western physical 9705938 BIRC3 Affinity Capture-Western physical 9705938 CASP1 Affinity Capture-Western physical 9705938 NOD1 Affinity Capture-Western physical 10329646 IKBKG Affinity Capture-Western physical 10880512 NOD2 Affinity Capture-Western physical 11087742 UBC Affinity Capture-Western physical 18342009 BIRC2 Reconstituted Complex physical 19464198 BIRC3 Reconstituted Complex physical 19464198 BIRC3 Affinity Capture-Western physical 19464198 BIRC2 Affinity Capture-Western physical 19464198 BIRC2 Affinity Capture-Western physical 19464198 UBC Affinity Capture-Western physical 19464198 UBC Affinity Capture-Western physical 18079694 IKBKG Affinity Capture-Western physical 18079694 MAP3K7 Affinity Capture-Western physical 18079694 TAB1 Affinity Capture-Western physical 18079694 TAB2 Affinity Capture-Western physical 18079694 BIRC2 Reconstituted Complex physical 21931591 BIRC3 Reconstituted Complex physical 21931591 XIAP Reconstituted Complex physical 21931591 BIRC2 Affinity Capture-Western physical 21931591 BIRC3 Affinity Capture-Western physical 21931591 BIRC2 Biochemical Activity physical 21931591 BIRC3 Biochemical Activity physical 21931591 UBC Affinity Capture-Western physical 19592251 NOD2 Affinity Capture-Western physical 19592251 MAVS Affinity Capture-MS physical 21903422 TRAF2 Affinity Capture-MS physical 21903422 MAVS Reconstituted Complex physical 21903422 NOD2 Affinity Capture-Western physical 15620648 NOD2 Affinity Capture-Western physical 15620648 NOD2 Affinity Capture-Western physical 21123652 NOD2 Affinity Capture-Western physical 21123652 RIPK2 Biochemical Activity physical 21123652 UBC Affinity Capture-Western physical 21123652