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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for BTRC (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000209 protein polyubiquitination IEA GO:0000278 mitotic cell cycle TAS GO:0006470 protein dephosphorylation IEA GO:0006511 ubiquitin-dependent protein catabolic process IDA GO:0007165 signal transduction TAS GO:0016032 viral reproduction TAS GO:0016055 Wnt receptor signaling pathway IEA GO:0016567 protein ubiquitination IDA GO:0030163 protein catabolic process IEA GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS GO:0031648 protein destabilization IMP GO:0033598 mammary gland epithelial cell proliferation IEA GO:0042753 positive regulation of circadian rhythm IEA GO:0043122 regulation of I-kappaB kinase/NF-kappaB cascade IEA GO:0044419 interspecies interaction between organisms IEA GO:0045862 positive regulation of proteolysis IMP GO:0045892 negative regulation of transcription, DNA-dependent IMP GO:0045893 positive regulation of transcription, DNA-dependent IEA GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS GO:0051726 regulation of cell cycle IEA GO:0060444 branching involved in mammary gland duct morphogenesis IEA GO:0061136 regulation of proteasomal protein catabolic process IEA GO:0071407 cellular response to organic cyclic compound IEA cellular_component GO:0005634 nucleus IEA GO:0005737 cytoplasm IEA GO:0005829 cytosol TAS GO:0019005 SCF ubiquitin ligase complex IDA molecular_function GO:0004842 ubiquitin-protein ligase activity IDA GO:0004842 ubiquitin-protein ligase activity IEA GO:0005515 protein binding IPI GO:0008013 beta-catenin binding IEA GO:0016874 ligase activity IEA GO:0045309 protein phosphorylated amino acid binding IEA

Protein-protein interaction details for BTRC (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID TRIM9 Two-hybrid physical 16189514 TBK1 Affinity Capture-MS physical 14743216 SMAD4 Two-hybrid physical 14988407 SMAD4 Affinity Capture-Western physical 14988407 SMAD3 Affinity Capture-Western physical 14988407 DLG1 Reconstituted Complex physical 12902344 DLG1 Affinity Capture-Western physical 12902344 DLG1 Affinity Capture-Western physical 12902344 CUL1 Affinity Capture-Western physical 12609982 SKP1 Affinity Capture-Western physical 12609982 IKBKB Affinity Capture-Western physical 11158290 NFKB1 Affinity Capture-Western physical 11158290 NFKBIB Affinity Capture-Western physical 10514424 BTRC Affinity Capture-Western physical 10644755 SKP1 Affinity Capture-Western physical 10644755 CUL1 Affinity Capture-Western physical 10644755 FBXW11 Affinity Capture-Western physical 10644755 FBXW11 Affinity Capture-Western physical 10644755 NFKBIA Affinity Capture-Western physical 10644755 UBE2R2 Reconstituted Complex physical 12037680 CDC34 Reconstituted Complex physical 12037680 NFKBIA Reconstituted Complex physical 9990853 NFKBIA Affinity Capture-Western physical 9990853 RELA Affinity Capture-Western physical 9990853 NFKBIA Affinity Capture-Western physical 9990853 RELA Affinity Capture-Western physical 9990853 JUP Affinity Capture-Western physical 10803460 SKP1 Reconstituted Complex physical 10918611 NFKB2 Affinity Capture-Western physical 11994270 CD4 Affinity Capture-Western physical 9660940 SKP1 Two-hybrid physical 9660940 CUL1 Affinity Capture-Western physical 10531035 SKP1 Affinity Capture-Western physical 10531035 UBE2D2 Biochemical Activity physical 10531035 CDC34 Biochemical Activity physical 10531035 SKP1 Two-hybrid physical 10531035 SKP1 Reconstituted Complex physical 10531035 HIPK2 Affinity Capture-Western physical 18765672 NFKB2 Affinity Capture-Western physical 18617892 PTTG1 Affinity Capture-Western physical 18460583 C13orf34 Affinity Capture-Western physical 18378770 C13orf34 Reconstituted Complex physical 18378770 PDCD4 Affinity Capture-Western physical 18296647 TP63 Affinity Capture-Western physical 17965458 TP63 Affinity Capture-Western physical 17965458 TP63 Reconstituted Complex physical 17965458 TP63 Biochemical Activity physical 17965458 UBA1 Reconstituted Complex physical 17965458 UBE2D3 Reconstituted Complex physical 17965458 EPOR Affinity Capture-Western physical 17327410 PHLPP1 Affinity Capture-Western physical 19797085 PHLPP1 Affinity Capture-Western physical 19797085 FAM123B Reconstituted Complex physical 17510365 GH1 Reconstituted Complex physical 17500058 GHR Reconstituted Complex physical 17500058 APC Affinity Capture-MS physical 19615732 CDC25A Affinity Capture-MS physical 19615732 CDC34 Affinity Capture-MS physical 19615732 HIVEP1 Affinity Capture-MS physical 19615732 HIVEP2 Affinity Capture-MS physical 19615732 IGHM Affinity Capture-MS physical 19615732 NRD1 Affinity Capture-MS physical 19615732 PRKACA Affinity Capture-MS physical 19615732 SERPINB4 Affinity Capture-MS physical 19615732 CUL1 Affinity Capture-MS physical 19615732 OGT Affinity Capture-MS physical 19615732 FBXW11 Affinity Capture-MS physical 19615732 KEAP1 Affinity Capture-MS physical 19615732 TUBGCP3 Affinity Capture-MS physical 19615732 NUDC Affinity Capture-MS physical 19615732 TUBGCP2 Affinity Capture-MS physical 19615732 CLPX Affinity Capture-MS physical 19615732 FBXW11 Affinity Capture-MS physical 19615732 SUN2 Affinity Capture-MS physical 19615732 COPS4 Affinity Capture-MS physical 19615732 USP47 Affinity Capture-MS physical 19615732 C13orf34 Affinity Capture-MS physical 19615732 GPRASP2 Affinity Capture-MS physical 19615732 KRT79 Affinity Capture-MS physical 19615732 CLSPN Affinity Capture-Western physical 16885022 CLSPN Affinity Capture-Western physical 16885021 SMAD4 Affinity Capture-Western physical 16865698 SMAD4 Affinity Capture-Western physical 16865698 CTNNB1 Affinity Capture-Western physical 16798748 CTNNB1 Affinity Capture-Western physical 16798748 EP300 Affinity Capture-Western physical 19297328 NFKB2 Protein-peptide physical 16303288 NFKB2 Affinity Capture-Western physical 16303288 ATF4 Affinity Capture-Western physical 16219772 CUL1 Affinity Capture-Western physical 15966899 PER1 Reconstituted Complex physical 15917222 PER1 Affinity Capture-Western physical 15917222 SMAD4 Affinity Capture-Western physical 15855639 CDC25A Affinity Capture-Western physical 15798217 SNAI1 Affinity Capture-Western physical 15647282 CLSPN Affinity Capture-Western physical 16885022 FBXO5 Reconstituted Complex physical 15469984 SNAI1 Affinity Capture-Western physical 15448698 SMAD4 Affinity Capture-Western physical 15314162 GLI3 Affinity Capture-Western physical 16705181 NFKB2 Affinity Capture-Western physical 15140882 WEE1 Affinity Capture-Western physical 15070733 SKP1 Affinity Capture-Western physical 15070733 CDC25A Affinity Capture-Western physical 14681206 CDC25A Reconstituted Complex physical 14681206 CTNNB1 Affinity Capture-Western physical 14516475 SKP1 Co-crystal Structure physical 12820959 NFKB1 Affinity Capture-Western physical 12482991 NFKB1 Reconstituted Complex physical 12482991 TNF Affinity Capture-MS physical 15485837 SNRNP70 Affinity Capture-Western physical 11850407 SNRNP70 Affinity Capture-Western physical 11850407 CUL1 Affinity Capture-Western physical 11850407 CUL1 Affinity Capture-Western physical 11483504 SKP1 Affinity Capture-Western physical 11483504 ATF4 Two-hybrid physical 11238952 ATF4 Affinity Capture-Western physical 11238952 CUL1 Affinity Capture-Western physical 10713156 NEDD8 Affinity Capture-Western physical 10713156 SKP1 Affinity Capture-Western physical 10514433 SKP1 Affinity Capture-Western physical 10514433 SKP1 Two-hybrid physical 10514433 CTNNB1 Affinity Capture-Western physical 10228155 AXIN1 Affinity Capture-Western physical 10228155 CTNNB1 Affinity Capture-Western physical 10228155 AXIN1 Affinity Capture-Western physical 10228155 CTNNB1 Reconstituted Complex physical 10228155 SKP1 Affinity Capture-Western physical 10228155 GSK3B Affinity Capture-Western physical 10228155 APC Affinity Capture-Western physical 10228155 NFKBIA Affinity Capture-Western physical 10066435 NFKBIA Affinity Capture-Western physical 10066435 CUL1 Affinity Capture-Western physical 10066435 NFKBIA Affinity Capture-Western physical 10075690 NFKBIA Two-hybrid physical 10075690 HEY2 Affinity Capture-Western physical 17217622 CASP3 Affinity Capture-Western physical 17217622 NFKBIA Affinity Capture-Western physical 9859996 MYC Affinity Capture-Western physical 20852628 MYC Biochemical Activity physical 20852628 RASA1 Phenotypic Suppression genetic 12151397 TP53 Reconstituted Complex physical 21521785 CDC25B Affinity Capture-Western physical 21807946 CDC25B Biochemical Activity physical 21807946 CLU Affinity Capture-Western physical 20068069 UBC Affinity Capture-MS physical 16196087 YAP1 Affinity Capture-Western physical 20048001 YAP1 Affinity Capture-Western physical 20048001 TP53 Affinity Capture-Western physical 19196987 CTNNB1 Two-hybrid physical 10074433 SKP1 Two-hybrid physical 10074433 CTNNB1 Affinity Capture-Western physical 10074433 APC Affinity Capture-Western physical 10074433 CTNNB1 Reconstituted Complex physical 10074433 IKBKB Affinity Capture-Western physical 19656241 IKBKG Affinity Capture-Western physical 19656241 IFNAR1 Affinity Capture-Western physical 18056411 CUL1 Affinity Capture-Western physical 18056411 BST2 Affinity Capture-Western physical 20980512 NFKBIA Biochemical Activity physical 20353940 DEPDC6 Affinity Capture-Western physical 22017877 DEPDC6 Affinity Capture-Western physical 22017877 DEPDC6 Biochemical Activity physical 22017877 SP1 Reconstituted Complex physical 19372209 PSMD4 Biochemical Activity physical 19240029 NFKBIA Biochemical Activity physical 19933270 SKP1 Affinity Capture-Western physical 19933270 NFKBIA Affinity Capture-Western physical 19933270 NFKBIA Reconstituted Complex physical 19933270 UBE2D1 Affinity Capture-Western physical 20378537 CDC34 Affinity Capture-Western physical 20378537 BMI1 Affinity Capture-Western physical 21430439 BMI1 Affinity Capture-Western physical 21430439 SNAI1 Affinity Capture-Western physical 19955572 IKBKB Affinity Capture-Western physical 20797629 MDM2 Affinity Capture-Western physical 20708156 MDM2 Affinity Capture-Western physical 20708156 MDM2 Reconstituted Complex physical 20708156 FBXW8 Affinity Capture-Western physical 21946088 IFNAR1 Affinity Capture-Western physical 21173164 NFKBIA Affinity Capture-Western physical 22022389 NFKBIA Affinity Capture-Western physical 20797629 IKBKB Affinity Capture-Western physical 20797629 NFKBIA Affinity Capture-Western physical 20797629 HNRNPU Affinity Capture-Western physical 20797629 MAPK14 Affinity Capture-Western physical 20797629 CSNK2B Affinity Capture-Western physical 20797629 DBN1 Two-hybrid physical 21900206 RASSF1 Two-hybrid physical 21900206 YAP1 Two-hybrid physical 21900206 ZC3H12A Two-hybrid physical 21900206 KIAA0947 Two-hybrid physical 21900206 PCDH8 Two-hybrid physical 21900206 KDR Reconstituted Complex physical 21402774 KDR Affinity Capture-Western physical 21402774 CUL1 Affinity Capture-Western physical 17318178 NEDD8 Affinity Capture-Western physical 17318178 NEDD8 Affinity Capture-Western physical 17318178 CUL1 Affinity Capture-Western physical 21249194 UBC Affinity Capture-MS physical 21987572 NFKBIA Affinity Capture-Western physical 20558726