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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for CDK1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000075 cell cycle checkpoint TAS GO:0000082 G1/S transition of mitotic cell cycle TAS GO:0000083 regulation of transcription involved in G1/S phase of mitotic cell cycle TAS GO:0000086 G2/M transition of mitotic cell cycle TAS GO:0000165 MAPKKK cascade TAS GO:0000186 activation of MAPKK activity TAS GO:0000187 activation of MAPK activity TAS GO:0000226 microtubule cytoskeleton organization TAS GO:0000278 mitotic cell cycle TAS GO:0002224 toll-like receptor signaling pathway TAS GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS GO:0006260 DNA replication TAS GO:0006281 DNA repair TAS GO:0006461 protein complex assembly IEA GO:0006468 protein phosphorylation NAS GO:0006916 anti-apoptosis IDA GO:0007049 cell cycle IDA GO:0007067 mitosis IEA GO:0007095 mitotic cell cycle G2/M transition DNA damage checkpoint IEA GO:0007098 centrosome cycle TAS GO:0007173 epidermal growth factor receptor signaling pathway TAS GO:0007264 small GTPase mediated signal transduction TAS GO:0007265 Ras protein signal transduction TAS GO:0007344 pronuclear fusion TAS GO:0007411 axon guidance TAS GO:0007569 cell aging IEA GO:0008063 Toll signaling pathway TAS GO:0008286 insulin receptor signaling pathway TAS GO:0009636 response to toxin IEA GO:0010628 positive regulation of gene expression IEA GO:0014038 regulation of Schwann cell differentiation TAS GO:0014070 response to organic cyclic compound IEA GO:0014075 response to amine stimulus IEA GO:0014823 response to activity IEA GO:0016477 cell migration TAS GO:0030261 chromosome condensation IEA GO:0031100 organ regeneration IEA GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS GO:0033160 positive regulation of protein import into nucleus, translocation IEA GO:0034130 toll-like receptor 1 signaling pathway TAS GO:0034134 toll-like receptor 2 signaling pathway TAS GO:0034138 toll-like receptor 3 signaling pathway TAS GO:0034142 toll-like receptor 4 signaling pathway TAS GO:0034501 protein localization to kinetochore IDA GO:0042493 response to drug IEA GO:0045087 innate immune response TAS GO:0045471 response to ethanol IEA GO:0045740 positive regulation of DNA replication IEA GO:0045931 positive regulation of mitotic cell cycle IEA GO:0045995 regulation of embryonic development TAS GO:0046686 response to cadmium ion IEA GO:0046688 response to copper ion IEA GO:0048011 nerve growth factor receptor signaling pathway TAS GO:0048678 response to axon injury IEA GO:0051301 cell division IEA GO:0051403 stress-activated MAPK cascade TAS GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS GO:0055015 ventricular cardiac muscle cell development IEA GO:0060045 positive regulation of cardiac muscle cell proliferation IEA GO:0070301 cellular response to hydrogen peroxide IEA cellular_component GO:0005634 nucleus IDA GO:0005654 nucleoplasm TAS GO:0005737 cytoplasm IEA GO:0005739 mitochondrion TAS GO:0005829 cytosol TAS GO:0005876 spindle microtubule IDA GO:0030496 midbody IDA molecular_function GO:0000166 nucleotide binding IEA GO:0004672 protein kinase activity NAS GO:0004674 protein serine/threonine kinase activity IEA GO:0004693 cyclin-dependent protein kinase activity IDA GO:0004693 cyclin-dependent protein kinase activity TAS GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity IDA GO:0016772 transferase activity, transferring phosphorus-containing groups IEA GO:0030332 cyclin binding IEA GO:0030544 Hsp70 protein binding IEA GO:0035173 histone kinase activity IEA

Protein-protein interaction details for CDK1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID FANCG Reconstituted Complex physical 15367677 GADD45A Reconstituted Complex physical 10362260 GADD45A Affinity Capture-Western physical 10747892 GADD45A Reconstituted Complex physical 10747892 FANCA Affinity Capture-MS physical 15082718 FANCC Two-hybrid physical 14499622 GADD45A Affinity Capture-Western physical 10973963 GADD45A Affinity Capture-Western physical 10973963 DAB2 Affinity Capture-Western physical 12881709 DAB2 Biochemical Activity physical 12881709 FEN1 Reconstituted Complex physical 12853968 CCNA2 Affinity Capture-Western physical 12853968 NSFL1C Biochemical Activity physical 12810701 CCNE1 Affinity Capture-Western physical 9891079 CCNB1 Affinity Capture-Western physical 9891079 CCNA1 Affinity Capture-Western physical 8565853 CCNE1 Co-purification physical 1388288 CCNE1 Affinity Capture-Western physical 1388288 LYN Affinity Capture-Western physical 8051175 LYN Affinity Capture-Western physical 8051175 LYN Biochemical Activity physical 8051175 LATS1 Two-hybrid physical 9988268 LATS1 Affinity Capture-Western physical 9988268 CDKN3 Two-hybrid physical 8127873 CDKN3 Affinity Capture-Western physical 8127873 CNOT7 Affinity Capture-Western physical 10602502 TP53 Biochemical Activity physical 10884347 CUX1 Biochemical Activity physical 11584018 LYN Affinity Capture-Western physical 8910336 FYN Affinity Capture-Western physical 8910336 MKI67 Biochemical Activity physical 10502411 TSC1 Reconstituted Complex physical 14551205 TP53 Affinity Capture-Western physical 11327730 CCNB1 Affinity Capture-Western physical 10973963 SPAG5 Biochemical Activity physical 11549262 BCL2 Affinity Capture-Western physical 11774038 BCL2 Affinity Capture-Western physical 11326318 LZTS1 Affinity Capture-Western physical 11504921 BRCA1 Reconstituted Complex physical 9244350 FANCC Affinity Capture-Western physical 9242535 CCNB1 Affinity Capture-Western physical 2570636 SFN Affinity Capture-Western physical 10524633 PRKCB Affinity Capture-Western physical 11901153 ZBTB16 Affinity Capture-Western physical 10497277 CDKN3 Two-hybrid physical 8242750 CDKN3 Affinity Capture-Western physical 8242750 CDC25C Reconstituted Complex physical 10864927 GADD45A Reconstituted Complex physical 12124778 GADD45B Reconstituted Complex physical 12124778 GADD45G Reconstituted Complex physical 12124778 CCNF Affinity Capture-Western physical 10716937 CCNB1 Affinity Capture-Western physical 10716937 MAP4 Biochemical Activity physical 7876309 UBC Affinity Capture-MS physical 18655026 UBC Affinity Capture-Western physical 18655026 CIITA Biochemical Activity physical 18245089 CCNA2 Affinity Capture-Western physical 17679094 CCNB1 Affinity Capture-Western physical 17679094 CDKN1A Affinity Capture-Western physical 17679094 HSPA4 Affinity Capture-Western physical 9247342 HSPA4 Affinity Capture-Western physical 9247342 HIST1H1A Biochemical Activity physical 9247342 CCNB1 Reconstituted Complex physical 9247342 CCNB1 Affinity Capture-Western physical 16784539 USP19 Affinity Capture-MS physical 19615732 USP32 Affinity Capture-MS physical 19615732 USP45 Affinity Capture-MS physical 19615732 UIMC1 Affinity Capture-MS physical 19615732 HMGB1 Biochemical Activity physical 2013279 HMGB1 Reconstituted Complex physical 2013279 CCNA1 Reconstituted Complex physical 1628647 CDCA2 Biochemical Activity physical 16998479 DLGAP5 Affinity Capture-Western physical 15145941 MGMT Affinity Capture-Western physical 16226712 CCNB1 Affinity Capture-Western physical 16159883 TSPYL2 Biochemical Activity physical 11395479 FOXM1 Affinity Capture-Western physical 15024056 FOXM1 Biochemical Activity physical 15024056 MLL5 Biochemical Activity physical 20439461 FANCA Affinity Capture-Western physical 15367677 FANCG Biochemical Activity physical 15367677 CCNA2 Biochemical Activity physical 19483727 EZH2 Biochemical Activity physical 20935635 UBC Affinity Capture-MS physical 16196087 CCNB1 Affinity Capture-Western physical 20228808 RYK Affinity Capture-MS physical 21875946 CSNK2A1 Biochemical Activity physical 1400350 ARID4A Biochemical Activity physical 21148318 EZH2 Affinity Capture-Western physical 21135039 EZH2 Affinity Capture-Western physical 21135039 EZH2 Biochemical Activity physical 21135039 HIST1H1D Biochemical Activity physical 21131960 EZH2 Affinity Capture-Western physical 21131960 EZH2 Biochemical Activity physical 21131960 EZH2 Biochemical Activity physical 21123648 CCNB1 Affinity Capture-Western physical 20367638 PPP2R1B Affinity Capture-Western physical 17540176 PPP2R1A Affinity Capture-Western physical 17540176 PPP2R1A Affinity Capture-MS physical 17540176 PPP2R1B Affinity Capture-MS physical 17540176 HDAC5 Affinity Capture-MS physical 21081666 RUNX1 Biochemical Activity physical 21059642 UHRF2 Far Western physical 21952639 CDKN1A Affinity Capture-Western physical 11559705 KAT5 Biochemical Activity physical 12468530 UBC Affinity Capture-MS physical 18781797 UBC Affinity Capture-MS physical 21987572