Database of mammalian genes
Home

Home Search Browse RAGs User guide FAQs Links Questions Contribute

Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for SH2B3 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID10019
Official gene symbolSH2B3
Full nameSH2B adaptor protein 3
Aliases,IDDM20,LNK,
Gene summaryThis gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus.
LocationChromosome: 12   Locus: 12q24
Gene position111843752 - 111889427  Map Viewer
Gene orientationplus
Gene size45676 bp
Gene sequence
OMIM ID605093