Entrez gene ID | | 10019 |
Official gene symbol | | SH2B3 |
Full name | | SH2B adaptor protein 3 |
Aliases | | ,IDDM20,LNK, |
Gene summary | | This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. |
Location | | Chromosome: 12 Locus: 12q24 |
Gene position | | 111843752 - 111889427 Map Viewer |
Gene orientation | | plus |
Gene size | | 45676 bp |
Gene sequence |
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OMIM ID | | 605093 |
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