Entrez gene ID | | 1002 |
Official gene symbol | | CDH4 |
Full name | | cadherin 4, type 1, R-cadherin (retinal) |
Aliases | | ,CAD4,FLJ22202,FLJ40547,MGC126700,MGC138355,RCAD, |
Gene summary | | This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. [provided by RefSeq] |
Location | | Chromosome: 20 Locus: 20q13.3 |
Gene position | | 59827559 - 60512299 Map Viewer |
Gene orientation | | plus |
Gene size | | 684741 bp |
Gene sequence |
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OMIM ID | | 603006 |
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