Entrez gene ID | | 10063 |
Official gene symbol | | COX17 |
Full name | | COX17 cytochrome c oxidase assembly homolog (S. cerevisiae) |
Aliases | | ,MGC104397,MGC117386, |
Gene summary | | Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13. [provided by RefSeq] |
Location | | Chromosome: 3 Locus: 3q13.33 |
Gene position | | 119396243 - 119388372 Map Viewer |
Gene orientation | | minus |
Gene size | | 7872 bp |
Gene sequence |
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OMIM ID | | 604813 |
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