Entrez gene ID | | 10125 |
Official gene symbol | | RASGRP1 |
Full name | | RAS guanyl releasing protein 1 (calcium and DAG-regulated) |
Aliases | | ,CALDAG-GEFI,CALDAG-GEFII,MGC129998,MGC129999,RASGRP,V,hRasGRP1, |
Gene summary | | This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq] |
Location | | Chromosome: 15 Locus: 15q14 |
Gene position | | 38857007 - 38780302 Map Viewer |
Gene orientation | | minus |
Gene size | | 76706 bp |
Gene sequence |
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OMIM ID | | 603962 |