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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CDK4 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 1019 Official gene symbol CDK4 Full name cyclin-dependent kinase 4 Aliases ,CMM3,MGC14458,PSK-J3, Gene summary The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq] Location Chromosome: 12   Locus: 12q14 Gene position 58146164 - 58142003  Map Viewer Gene orientation minus Gene size 4162 bp Gene sequence >CDK4:complement(20285309..20289470):Length=4162 GCCCTCCCAGTTTCCGCGCGCCTCTTTGGCAGCTGGTCACATGGTGAGGGTGGGGGTGAG GGGGCCTCTCTAGCTTGCGGCCTGTGTCTATGGTCGGGCCCTCTGCGTCCAGCTGCTCCG GACCGAGCTCGGGTGTATGGGGCCGTAGGAACCGGCTCCGGGGCCCCGATAACGGGCCGC CCCCACAGCACCCCGGGCTGGCGTGAGGTAAGTGCAGTCCCTTCCCAGGAATGAGAACCA GTGCCCGCCCCCCTCACAGCTTTCCACGCGTTCGTTTCGCGAGCTGGTTATGGAAGGGTC GCTCAAGGGCGGGAAGTGGGGCCTTTGTGGTCATGGGAAAGTATAATTTTAGGGACTGAG GTGTAGGATCTTCGATGCAAGGCATGTGTCATGTGTGATCTTTGTGCGGGGCGCGATTGT CCCAAAGGAAAAAGCGTTTTCTATTGCAGGGCCTCACGTGGCTGGAGGGGTTGGTATTGA GTCATTGTGTTATCTCTGGGGCCGGCCCCAAGGAAGACTGGGAGCGGGGGATGGGATGCT GGTGGTGTTCTTTGCGCTTTTTTTTTGGGAGTCCCTTTGTTGCTGCAGGCTCATACCATC CTAACTCTGTAAGCGACTTTTGGTGATAGGAGTCTGTGATTGTAGGGTCTCCCTTGATCT GAGAATGGCTACCTCTCGATATGAGCCAGTGGCTGAAATTGGTGTCGGTGCCTATGGGAC AGTGTACAAGGCCCGTGATCCCCACAGTGGCCACTTTGTGGCCCTCAAGAGTGTGAGAGT CCCCAATGGAGGAGGAGGTGGAGGAGGCCTTCCCATCAGCACAGTTCGTGAGGTGGCTTT ACTGAGGCGACTGGAGGCTTTTGAGCATCCCAATGTTGTCCGGTGAGAAGGTGGTGGAGG GTTGGGCGTGGGGAGTAAAGGGAAAAGACAGCCTATAGGTGGGGTGTGATGATCTGTAGA GAAGTGGGGACCCTGAGGAAATAATGAGAGGCCATGTTGGGTTAAAGGGGATTGAAAAGT GAGCATTTACTCTGGTCAGGCTGATGGACGTCTGTGCCACATCCCGAACTGACCGGGAGA TCAAGGTAACCCTGGTGTTTGAGCATGTAGACCAGGACCTAAGGACATATCTGGACAAGG CACCCCCACCAGGCTTGCCAGCCGAAACGATCAAGGTGAGTGGGGTTGGTAGGCATTGAG AGGTGGATTGGGACCTTTGTAGTAGAACCTTCTGGGATTTCAGGTATGGTGCCTAGTTTC CAGTGCATCTGTACCTCCCCTTTGAAACTAGGATCTGATGCGCCAGTTTCTAAGAGGCCT AGATTTCCTTCATGCCAATTGCATCGTTCACCGAGATCTGAAGCCAGAGAACATTCTGGT GACAAGTGGTGGAACAGTCAAGCTGGCTGACTTTGGCCTGGCCAGAATCTACAGCTACCA GATGGCACTTACACCCGTGGTCAGTAGAAAGATGGTACCAAAATGGGTTCTGGTTGGGAG TAGGAGAGTGATTGCCCGTAGCAATTGAGAAGTCATGTGCTTCATGTGTTCAGTCAAGCA AGTTGTGTTTCATGGTAACCCATGGGGTCCCCATCCATTCTTCCTATTCCCTTTAGGTTG TTACACTCTGGTACCGAGCTCCCGAAGTTCTTCTGCAGTCCACATATGCAACACCTGTGG ACATGTGGAGTGTTGGCTGTATCTTTGCAGAGATGTTTCGTCGAAAGTATGGGACCCACA TACCCTGGACTACCTTGAATTCCCCAAATCGCTTGTTCATAAACCACATCCATACCTTGC CCATTCTTTTTTTTTGAGACCAGGGCTTGCTGTGTTGCCCAGGCTGGATTGCAATGGCAT GATCACAGCTCACTGCAGCTTCAACCTCCTGGGCTCAAGTGATCCTCCCATCTCAGCTTC CCAACTAGCTGACACTACAGGCACGCACCTCCATGCTTGGCTAGTTTGTTAATATTTTTA TAGAGATGGGGTCTCAGTATATTGCCCAGGCTGGTCTTGAACTCTTGCACTCAAGCAATC CTCCCACCCCTACCTCCCAAAGTAGCATAAGCTACTGCATCTGGCCCCATTCTTTTACTT GCGTACTACTAACTTGCCCATAGCAGAAAGCTCTGAAATGTTCTGGAATTAGGAACTTCA TATCCCTTTATTCTCTTTATTTTTTATTTATTTATTTATTTATTTATTTATTTATTTATT TATTTATTGAGATAAGGTTTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCCCAATTACA GCTCACTGTAGCCTCTACCTCCTGGGCTAAAGCAATCCTCCCATCTCAGCCTCTTGAGTA GCTGAGACTACAGGTGCACGCCACCATGACTGGCTTTTTTTTTTTTTAGATGGAGTCTTG CTCTGTCGCCAGGCTGGAGTGCAGTAGTGCGATCTCTGCTCACTGCAACCTCCACCTCCC AGATTCAAGCAATTCTCTTGACTCAGCCTCCCAAGTAGCTGGGACCACAGGTGCACGCCA CCATGCTCAGCTAATTTTTGTACTTTTAGTAATGACAGGGTTTCACCATGTTGGCCAGGA TGGTCTCGATCTCTTGACCTCATGATCCACCCACATCAGACTCCCAAAGTGCTAGGATTA CAGGCGTGAGCCGCTGCACCTGGCATTTCTTTTTTTTTAAAAAAAGAGACAAGGTCTTGC TTGCCCAGGCTGATCTAGAACTCCTGGGCTCAAGCAGTCCTCTCACCTCAGCATCCCAAA GTGCTGGAATTGTTGGCCTTTATTCCCTATACTTCCTATTTTGAGCCACTAAGCAGTAAC CATTCAACTAAGATATCTTTGAAAATGACTGCTACCTTATATCCCTTCTCACCTTAGGCC TCTCTTCTGTGGAAACTCTGAAGCCGACCAGTTGGGCAAAATCTTTGAGTAAGTGACCAA CATGGGAGAAAAAGATTTTCTATTCTGAGTCCTCTTTCTGCTGAACCCAGGATGGCAACT GGCTCTGCCCATGGGGATGGGAACTGGAGGACCCTCCTGACCAGAGTTCTCCTGTCCCCC ACAGCCTGATTGGGCTGCCTCCAGAGGATGACTGGCCTCGAGATGTATCCCTGCCCCGTG GAGCCTTTCCCCCCAGAGGGCCCCGCCCAGTGCAGTCGGTGGTACCTGAGATGGAGGAGT CGGGAGCACAGCTGCTGCTGGTACTGGAGATGGCTGTGGGCACAGGGAAAGAAATAGAGA CTGGGGAAAGAAATAGAGCAGTATGCAGGGCCCTGGCCACTGTGGTTAATGAAACTTGGT TGGTAGATGGGCTGTAGTTTTTATTACAGCTGCAAATAGCCACCCACAGAGAAGGATATA GAAGAGAACCCATCCTGGCTGGGCACGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGA GGCCAAGGTGGGCGTATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTG AAACCTCGTCTCTACTAAAAGTACAAAAATAAGCCGGGGGTGGTGGCACACGCCTGTAAT CTCAGCTACTTGGGAGGCTGAGATAGGAGAATCACTTCAACTCAGGAGGCGGAGGTTGCA GTGAGCTGAGATCATACCATTGCACTCCAGCCTGGGTGATAGAGCGAGACTCCGTCTCAA AAAAAAAAAAAAAGAAAAAAGAAGAAAGCTCATCCCAGGTATTGTTGTGGGTGGGCAGAA GTCTGTTTTCTTCATGGTTTTCTGACCTTTGCCTCTCCCCTCAGGAAATGCTGACTTTTA ACCCACACAAGCGAATCTCTGCCTTTCGAGCTCTGCAGCACTCTTATCTACATAAGGATG AAGGTAATCCGGAGTGAGCAATGGAGTGGCTGCCATGGAAGGAAGAAAAGCTGCCATTTC CCTTCTGGACACTGAGAGGGCAATCTTTGCCTTTATCTCTGAGGCTATGGAGGGTCCTCC TCCATCTTTCTACAGAGATTACTTTGCTGCCTTAATGACATTCCCCTCCCACCTCTCCTT TTGAGGCTTCTCCTTCTCCTTCCCATTTCTCTACACTAAGGGGTATGTTCCCTCTTGTCC CTTTCCCTACCTTTATATTTGGGGTCCTTTTTTATACAGGAAAAACAAAACAAAGAAATA ATGGTCTTTTTTTTTTTTTTAA OMIM ID 123829