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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PSME3 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 10197 Official gene symbol PSME3 Full name proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) Aliases ,Ki,PA28-gamma,PA28G,REG-GAMMA, Gene summary The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Two transcript variants encoding different isoforms have been identified. [provided by RefSeq] Location Chromosome: 17   Locus: 17q21 Gene position 40985423 - 40995777  Map Viewer Gene orientation plus Gene size 10355 bp Gene sequence >PSME3:6259575..6269929:Length=10355 GGCGTGAGCGGCGAAAGCCGGGAGGGCGAGCGAGAGAGCAAGCAGGCAGCAGGCTGCCGG CGGGCGGGCGGACGGCACAGAGGGAGGGAGCGAGCGAGCAGTGAGTAAGCCAGCAAGGGC GGTCGGGTCCCGAGGTCAGCCGAGATTTCTCAGGTCCCTCCGGCCCCCTCCCTGGAGTCC ACAGCGCCTCCGGTGTCCAGAGGATCGGACACGGCCCGGCCCGGCCATGGCCTCGTTGCT GAAGGTGGATCAGGAAGTGAAGCTCAAGGTAGCGGCACCGGTCCGGCCTTTTTGCCCCTC GCTTTGATCCCCCAGCAGTCTGACCGGCTTCCTACTCCCCATGGCGTCTTTGTCTCCCTG GGGATACCAGCTCTGAGCTTCCGCTCGGCTCAGCCCAGCCCCCAACTCCCGGGGTCGGCT TCGCGGGAGAGGAAAATATAGGATGGCTTTCTGTACCGCGTCTGATGATGGAGAGTCCCG GGGACACCTCCGCGGACACGTGTTGGACTCAGGGCTTTAGGCCCGTGACAGCTGGTAATC CCCCAGCCCAACAACGTCCCTGGACACTGCCCCTGCCCTTGGCGGCTGGCCTGCCTAGTA TCATAGACTAGGTCTGGGTGGGGGTTGGCACGTTTGTGAGCTCACATCTTCCCTAACTAC CTGTCTTTTGTCTGCTTATCAAATTCAGACAGCTTCAGACACAGGAGGAAGGGAGGGAAG GGGGAGGACAGAGGAGACAGGCAGGTGCTGTCCTCAAAGCCCTGCGTTCTTCTGAGATGG AAAAATGGATCCTCAAAAAAATAAAGTATTTGCAGTCTGGGGGCCTCTCAGCTTCTTATT ACAGTTACAAGGTGAGGGAAAGACAGTTGGATTGGGATTCTCCATCCTGCTCTTACCTCT GTCCCCAGGTACTGAATTGCTCTCTTTGTTAATTTTAGGTTGATTCTTTCAGGGAGCGGA TCACAAGTGAGGTGAGTGAAATAAATAGAAAAATGGTTGTTGGTTGAGAATTTCCCAAAG AGGAGATACCTGGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGACCTTCCCACAGATATT AATTCAGCTGTATTTTCCCTCTTCCTTAGGCAGAAGACTTGGTGGCAAATTTTTTCCCAA AGAAGTTATTAGAACTTGATAGTTTTCTGAAGGTGAGAGACCCTATTCTTTCCTCAAATT CCCCAATTTTTTTGGCCCTGGTATTACTGTCAACTGGGATAAACTGTTGATTCTTCTTCT TTTTATTTTTTTAAACTGTAAAAGCACTTTCATTTCTTGCTCTTCAAATCAAATACTTCT TTGTTCAGCTTGAAAAGATTAATGTTTTGGGGTGGGTGTCTTTCAGGAACCAATCTTAAA CATCCATGACCTAACTCAGATCCACTCTGACATGAATCTCCCAGTCCCTGACCCCATTCT TCTCACCAATAGCCATGATGGACTGGATGGTGTAAGTGTCCTATATTTATCTTTGTGTTC TTGAGCAGTAGGTCCTCTGTCCTCTGTTTCCTTGTCAGTTTAAGATGTACAGAGGGAACA GTGGGATTTGGATCTGGGAACTAGGACTCTGTTACAGACATGATGACTCTAGTATAGTTC TTTTATTTCTTATTTATTTATTTATTTTTGAGAAAGGGTGTCACTTTTTTTGCCCAAGCT GGAGTGTAGTGGCGGGAATGCTGCTCACTGCAGCCTTGACCTCCCGAACTCAAGCGATCC TTCCTCCTCAGCCTCGCAGGTAGCTGGGACTACAGGAGTCCACCACCATGCCCACTGATT TTTGTATTTTTTGTAGAGATGGGGTTTCACCATGTTGCCCAGGCCGGTCTCAAACTCCTG AGCTCAAGTAATCCACCCGCCTCAGCGTCCCAAAGTGCTGGGATTACAGGCGTGAGTCAC TGCACGGGGACTCCAGTATATTCCTTTTAGACCCTCAGTTTCATTTACGACGTGAAGTGA ATGTGCTAATGCTACTGTCAGTGTTAGAGTGAGTTTCAAATAAAAGAGAACTAGCTTAGG CCAGGCACCTTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGACGTGGACGGATC ATGAGGTCAGGAGATCAAGACCATCCTGGCTAACACCGTGAAACCCTGTCTCTACTGAAA ATACAAAAAATTAACTGGGTGTGGTTGTGGGCCCCTGTAGTCCCAGCTACTTCGGAGGCT GAGGCAGGAGAATGGCATGAACCCAGGAGGCGGAGCTTGCAGTGAGCTGAGATTGCGCCA CTGTACTCCAGCCTGGGCGACAGAGCGAGACTCTGTCTCAAAAAAAAAAAAAGAGAACTA GCTTCATCAGGTTACCTGGTTTTTCCCATGGCTCTGAACAAGACTTTGCTTATATTTGTT TGCATGTCTTGAGTAGTGTTATGGGATATGCAGTTCTCGCTATGTAACTGCAATTGCTAT CTTTGCTTTGCATCTCTAACACCTAGTCCTTATCAGTCATGTGTCCACATGCTACTATAA CACTGATGATACCGTATTGTTGTCTGTAGTACTGCCTCATTGTTGAACTTGTACATCTGG AAGGCAGGAACTATCTTTTTTTTTTTTTTTTTTTCCTTGAGACAGAGTCTCACTCTGTTG CCTAGGCTGGGTGCAGTGGCGCGATCTCAGCTTACTGTAACCTCCGCCTCCCGGGTTCAA GTGATTCTCCCACCTCAGCCTCCCACGTAGCTGAGATTACAGGTGCACACCACCACGCCC AGCCAATTTTTTTATTTTTAGTGGAGACAGGGTTTCACCATGTTGTCCAGACTGGTCTCG AACTCCTGACCTCAGGTGATCCGCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGCCA TGAGCCATCGTGCTCGGCCGGCAGGAGCTATCTTAATCTTTGTATTCCCAGCACCTAGTG TTGATCCTGGTCCCTAGCAATTGCTGAATACATGTTTGTTAACTGAATAATGTGTTCCTT TGTGGAACCAGCAGATTTGTACGTATTCCCTTAATTATCTTCCCTGCTTTGATTGGTTCT TTTTTCCTATTCTTTATAATACTTAATGTATTGTGTTTCTGGAAAGATTGGTCTTCCCAA CTAGAGCGTAATTTGCTTTGTGGTAAGAACCTTTTCTTTCTTTCTCTGAGGGGGAACCCA GTCTCACTCTGTCACCCAGGTTGGAGTGCAGTGGCTTAATCTCAGCTCACTGCAACCTCA AACTCCTGGGTTCAAGTGATCCTCCTACCTCAGCCTCCCAGGTAGCTGGGACTACAGGTA CATGTGCCATCACATTCAGCTAGTTTTTGTATTTTTTGTGGAGACAGGGTTTCCCTATGT TGCCCAGGCTGGTCTCAAGCTCCTGAGCTCAAGCGATCTGTGTGCCTTGGCCTCCCAAAG TGCTGGGATTACAGGTGTGAGCCATGGCGCCCAGCCCAAGAACCTTTTCTTTATTTCCTT TTTTTTTTTTTTGAGGTGGAGTTTCACTCTTGTCACATAGGCTGGAGTGCAGTGGCACAA TCTCGGCTCACTGCAACCTCTACCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTTCC GAGTAGATGGGATTACAGGTGCCTGCCACCACACCCGGCTAATTTTTTTTATTTTTATTT TTTGGAGATGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGTGCAATCTCGGCTC ACTACAACCTCTGCTTCCTGGGTTCAAGCAGTTCTCTGCATCAGCCTCCCAAGTAGCTGG GATTATAGGTGCTTGCCACCACGCCCAGCTAATTTTTGTATTTTTAGTGGAGATGAGGTT TCACTGTCTTGGCCAGGCTGGTCTTGAACTCCTGACCTTGTGATCCACCTACCTTGGCCT CTTAAAGTGCTGGGATTACAGGCATGAACCACCGCGCCTGGCTAACTTTTTGTATTTTTA GTAGAGATGGGGTTTCACTATGTTGGCTAGGCTGGTCTCAAACTTCTGATCTCAGGTGAT CTGTCCACCTCGGCCCCCCAAATTGCTGGGATTACAGGCATGAGCCACCGCGCCTTGCCT CCAATAACCTTTCTTAAAGCTTTGTATGTACTTAGGAAATTGTGCAGAAATTAATAACAT AAGCTATGAGGCTGAGGAAGGGATTAAACTTGCTTGAAGGGTATCTTGTGATGGAGATGT GGGTGTCAAAACTAGGCTCATCCCTGCCTCTTTGTATCCTTAGCCCACTTATAAGAAGCG AAGGTTGGATGAGTGTGAAGAAGCCTTCCAAGGTAAGAGGCACCCTTACCTCACCTCCCC TCACCCCATCCCTGACTTGCAACCCTGAGAAGCAGGATGGATCTAGTGTTCTCCTGACCA GGAGGCAAGATCTAATCTTACTTCCCAGAGGTAGCATTCCCAGCTCCTCCAAACGTGCTT GTTATTGAGTGCTCTAAACCTGGTTTTCCAATAAACAGAGGATTTAAGACTTTTGTTATG TTTTAGACGCTCATCTGTAGTTCTTTTTTTCCATACATTCTCGTTGATTCTAATAGTGGT GTCATGGTAGGATTGTGACAAAGGCAGAGGTCATAGCATCTGATAGGTATAGGGAAAATG AGAGAGAGGCAGGGGATGCTGTGTCCTTCCCTCTTCCCTGATCATTTGACCTTCACATCT CTGCCAGGAACCAAGGTGTTTGTGATGCCCAATGGGATGCTGAAAAGCAACCAGCAGCTG GTGGACATTATTGAGAAAGTGAAACCTGAGATCCGGCTGTTGATTGAGAAATGTAACACG GTGAGGCACAGGCTGGTGACCTATGGGCCGGCCCCAAGTACCCCACCTGAAGTGCAAAAA ACAGTGGATGTACGGGTGGTATGGGAATTGGCAGACTAGGTTTTTTTGAGTTTTTTTTTT GAGATGGGGTCTCGCTCCATCACCCAGGTTGGAGTGCAGTGGCGCCATCTCGGCTCACTG CAACCTCTGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGAT TACAGGTACCTGCCAACACACCCAGCTACTTTTTGTATTTTTAGTAGAGACGGGGTTTCA CCATTTTGGCCATGGTTAGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCACCCG CTTCGGGGTCCCAAATTGCTGGGATTACCGGCATGAGCCACCATGCCTGGCCAGACTAGG TATTTTGACTTCTGTGTTCCTGGCATCTGGCTCCAGCCGTCTGAATTGTGTACTTCATGG CTTCAGCCTTCAGGCAAAGGTCCTCATATATGTTTTGACCTCCAGGTCAAAATGTGGGTA CAGCTCCTGATTCCCAGGATAGAAGATGGAAACAACTTTGGGGTGTCCATTCAGGTAATG TACTTGAATTACATACTGGGAAGAGTGGCTTGGGAGATACTCTCATCTCCCCTGCGTTAC CTTTTTTTCCTTTTTCTTTGGGGCTGCTGTGGATGACATGGAAGTGGCTTTTGATGCACC TGTTGTTTGTTTGTTTTAGGAGGAAACAGTTGCAGAGCTAAGAACTGTTGAGAGTGAAGC TGCATCTTATCTGGACCAGATTTCTAGGTAGGGCTGCTTGGGCTTGGCCGAGGCGTTGGG GGCTGATGAGGTGGTGGGCACCATCAAGGGTCTCCTGCATCTTCCTCCTCTTCTCTCTCT TTCCAGATATTATATTACAAGAGCCAAATTGGTTTCTAAAATAGCTAAATATCCCCATGT GGTAAGTAAGGGGTTTGTGGCCTGAGGGTGGAGGTGGCAGGATAGTGAAGAGTGACTGTT ACTGGGAAGGAGCTGTCTGGAAACAATTGGGCTTTGGGGACTAGCTTTTTCCTGTACCCT CCTTGCAGGAGGACTATCGCCGCACCGTGACAGAGATTGATGAGAAAGAATATATCAGCC TTCGGCTCATCATATCAGAGCTGAGGAATCAATATGTGAGTAATCTCAGTCCTTGTCCAT AGTTGCTGTGGCTTCTCTTAGTTCTGTTGAGAGTATTGTTAAAATTCTCTGAAGGGCTGA GATGAGGGTCTGAGGTAAAATGAATAGACCAAATTCTATTCATCACCTGAGTGTTGAGAA CCATGAAGTCATCTAGCAGGGTATCTCTCTTTTTTCTACCTGAGTGGAGGGGTGTGCAGT ACAATATGGTTAAGATATAGGTGTCAGAGTCAGACAGACTTAGGTTTGCAACCAGGCTCT ACCTGTGTTGTGTGACCTCGAGCAAATTGTTCAAGCTTAAACTTCAATTTCTTCTTTAAA ATGGGACTGGGCTGGGCGCAGTGGCTAATGCCTGTAATCCCACCACTTTGGGAGGCCAAG CCGGGTGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGATCAACATGGCGAAAGCTC GTCTCTACTAAAAATACAAAATTAGCCGGGCCTGGTGGCACATGTCTGTAATCCCAGCTA CTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGTTGGAGGTTGCGGTGAGCCA AGATTGCTCCATTGCACTCCAGCCTGGGCAACAAGAGCGAAACTCCATCTCAAAAAAAAA ATAAAAATAGGCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCACTTGAGGT CAGGAGTTCGAGACCAGCCTTACCAACATGGAAAAACCCCATCTTTACTAAAAAAAAAAA AAAAAAATTTAGCCGGGCGTGGCGGCACATGCCTTTAATCGTAGCTACTGAGGAGGCTGA GGCGGGAGAATTGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATTGCGCCACT GGACTCCAGCCTGGGCAACAAGAGCGAAACTCCGCCTCAAATAAAAATAAATAAAATAAA ATAAAATGGGACTGAAGAGGCCGGGTGTGGTGGATCACACCTGTAATGCCAGCACTGTGG GAGGCTGAGGCAGGTGGATCACATGAGGTCAGGAGTTTTTGACCAGCCTGGCCAACATGG TGAAACCCCATCTCTACTGAAAATACAAAAAATTAGCTGGGCATGGTTGGCGGACCCCTG TAATCCCACCTAATCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAAGAGGTGTAGGT TGCAGTGAGCCGAGATCGTGCCACTGTACTCCAGCCTGGGCAACAAGAGCAAAACTCCGT CTCAAAAAAAGAAAACAAAACTGAAGAGTACCTACTGCACAAAATTCATTCGCTTTTTTA AAATAAGTGAGATAACACATTGAAGGACCTGGTACAATTCTTACTATGTTAAGTGCACAA TACATGTTAGTTGTTATTAGACACTTGGGGCCTTGGAAATACCCATTTATACCCAGTTGA AGTATAAGAGAGGTGGTGCTGCCACCCTGAATGCAGGCTCAAGTGAGATTAAAATTACAG TAAGTTGGCCGGGTGCAGTGGCTCACGCCTGTAACCCCAGCGCTTTGGGAGGCCGAGGCG GGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACATGGTGAAACCCCATCTG TACTAAAAATAAAAAAAATTAGCCGGGTGTGGTGGCAGGCGCCTGTAGTCCCAGCTACTC AGGTGGCTGAGGCAGGAGAATGGCATGAACCTGGGAGGCGGAGGTTGCAGTCAGCCGAGA TCGCGCCATTGCACTCCAGCCTGAGCGATAGAGCAAGACCGTGTCTCAAAAAAAAAAAAA AAAAAAAATACAGTAAGTCTTCACTTAATGTTGTCCATAGGTTCTTAGAAACTGCGACTT TAAAAATGATGTATATCAAAACCAAGTTTTTTTTTCATTAACATTGTAACAAAATGACAT CGAACAAAATGATGTTATTTGAAACCAGGTTATTTGAGGACCTTCTGTACTTGATTTGCT TACCTGCTGTACTTTAATTTCCTTCAAGTCGCAGTTGCTAAGAACCTATTGATGACATTA AGGACTTACCGTATGCAGATGATTGCTTGGGGATTTGTGAAGGGGTCTCTCATTTTCTTG ATGAGGTAAGGGTTGTACAGATATGTGATTCCCCTGATCCCTCTTCTCTCAGGTCACTCT ACATGACATGATCCTGAAAAATATCGAGAAGATCAAACGGCCCCGGAGCAGCAATGCAGA GACTCTGTACTGAGGCCAGGGCCAGGGCCAGGGGACTCTGTGAGTCTGGCTCAAGACCGA CATTGCCTTGGTTTGTTACATGACTATCGTGATGGGGAAACTGGCTGGAAATAGTAATCA CACCTCTCTGTTTTTAGTTAGAGTCTAATGAAACTCTCATCTAGTTCTGTGATGTGTTTA CCTCTTTTTTCAGGCCTCAGGAACTCTTCTATTTCCTTCCCTAATACCCCACACCCAACC TGTCGTAATTTCTGGAGAACTCCAGGTTTGTGTGTGCAGGATGTTGGCACAAAAATACCT GTGTTTTCATTCTCCCCCTCTCTCCCTCCTGTGTCTTGCGCTTTATGTTTTCTTCCGTTT GATAATTAGTTGGTTAAAAGCTGAGGGAACCGGAAGGAAAGTGCTAGGTGTTTTTTAGGA ACTAGGGTGGCGGGGGGACGAACTTCTCTTCCTCACATGAGGTTACTGTTTCTTTCCTCT GTGGGGCATTGGATCCTCCCACAGTTGCCCTGGTGATGACTTAGGGCTTCCCATCTGTGT ACATCCCACTTTGAATCTTGATCGTGACAAGAAATACCTTAGGCCTTCAGTCAATTCCGA AGCTCCTTCAGTTGTTTTTATAATGGGCGTTTTCACATGCACATATGTGTATGCATGTAT ACGCCCATACAGACATGCACACACAGACTCCTACTCCATTAGCTAACATACCCTCCCTCT CCACAACCCCTGTCACATACCTTTCAGGAGGTGACAGTTGTCTTAGTTGTCATCTACCCA GACAAACGTCCTGGGCCCGTCCTCCCTCCTGATACTGTAGCCTCTTGGTACCCAGGGTGA GTTGGTGGAGAACAGAGAGATGAGAAGCAGAGGGCTTGGGGAAAGCCTGTTCCTCTCTGA CTCAGCCCTTTTTGGCATTATTGCAAGAGCTTGACTCCTGGTTGCCTTTTCCCAGCCAGT TTTCAGTTGGGGTGAAGGTTTCTGCAAGTGTGAGGTCCAGATGCTGCTGCTCATGTTGGG CTTTCCTTTTGGGAACTATTTCTCTTTATTTATAGTGTCGGGCTTCCGGGGAAAGCAATC ATTGGTGTGTATGTGTATGTGCATGCACACACGTGCATATACACATTTGTGTATGTGGAA ATGTGCTGGGCAAGTCAAAACTATAGAAGAGTTGCCTCCTGTCTCTCGAATCTTCCAGAG ATATCACTTAATTGTTAACAGCTTTTGTGTTAATCCCCTTCAGCCCCTAGCTCTTTTATT CTACCACGGCTGGAGAGTTGATACCTGCAGTCAGCCTGCCAGTGACTCTTAGTGTCTGTT TCTGACTTATTTTTCCTGTCTCTGTCTTCCAACCCCCAATAATATTTCCACCGGGGATGC ATCATTTTTACTCCCAATATTCTGTAGAGAGGGAGTCAGGATGCTGTCTTCCCACGAATA GTACTCAGTAACAAACCAATTGCATTTTAGTTGGGCAGTGCTCCCACCCACCCTCCAGAT CCCTTCCAGCTAAAACCCTTCCCCCTTCCCTCCATGTGTTTCTCAGTTTCCCGTTTCGTT TGTTGGACTGTTCCACTGCCCCTCCTCCTCACCCTATCACCCATGGATCGTAATGTAAAA TTCTTTTACCATGTCAAGAAATTATTAAAAATACAGGTACTTTGACCTCTTTCTAAAGCC GCAGACCCTGGTGCAATGCTCTGGTGGCTAGGGATGTACTCATGCTCATATGTGTGCACG CTTGGACACCCACCTCCATGGACACCTAGCCACCCTGTTGTGTGTCCTTATGCCAGTTGA GCTGAATCTTTTCCCCAGTATAGTGGAAAGACTGAGGCTTCTGCCTACTGAGCAAGGTTG GGTGCTTCATTTGTGTTCAGTCTGAATTATGGGAAAGTTAGCTCTTCCCAGACCTAAGCT GCCTTCTCTCCCTACTTTCAGAAGATCCTAGTTCCTTCCTTCCCGAGTGATACCCATGAA CTGCCAGTAGAGGCTGCTATCGTTCCATGTGTAAGGAATGAACTGGTTCAAGGCGCGTCC TACCCAGTCATTTTCTTTACCTTATACTAATTCTTCCTGAATAATGTCTTCAGTTTCTTG AGGAGACTCCTAGTTTTGGTTTTCAAATTACTTGGAGGGCTGCCTAGGAATCTATCTCCC TCTGAAATAAAGTTTCCTCATCTTCCACCTTGCAA OMIM ID 605129