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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CDK6 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID1021
Official gene symbolCDK6
Full namecyclin-dependent kinase 6
Aliases,MGC59692,PLSTIRE,
Gene summaryThe protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq]
LocationChromosome: 7   Locus: 7q21-q22
Gene position92465941 - 92234235  Map Viewer
Gene orientationminus
Gene size231707 bp
Gene sequence
OMIM ID603368