Entrez gene ID | | 10267 |
Official gene symbol | | RAMP1 |
Full name | | receptor (G protein-coupled) activity modifying protein 1 |
Aliases | | ,-, |
Gene summary | | The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. [provided by RefSeq] |
Location | | Chromosome: 2 Locus: 2q36-q37.1 |
Gene position | | 238768187 - 238820756 Map Viewer |
Gene orientation | | plus |
Gene size | | 52570 bp |
Gene sequence |
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