Database of mammalian genes
Home

Home Search Browse RAGs User guide FAQs Links Questions Contribute

Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for UBE4B (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID10277
Official gene symbolUBE4B
Full nameubiquitination factor E4B (UFD2 homolog, yeast)
Aliases,E4,HDNB1,KIAA0684,UBOX3,UFD2,
Gene summaryThe modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq]
LocationChromosome: 1   Locus: 1p36.3
Gene position10093016 - 10241297  Map Viewer
Gene orientationplus
Gene size148282 bp
Gene sequence
OMIM ID613565