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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for SF3A1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID10291
Official gene symbolSF3A1
Full namesplicing factor 3a, subunit 1, 120kDa
Aliases,PRP21,PRPF21,SAP114,SF3A120,
Gene summaryThis gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family; named for the SURP (also called SWAP or Suppressor-of-White-APricot) motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]
LocationChromosome: 22   Locus: 22q12.2
Gene position30752913 - 30727977  Map Viewer
Gene orientationminus
Gene size24937 bp
Gene sequence
OMIM ID605595