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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CDKN2B (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 1030 Official gene symbol CDKN2B Full name cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) Aliases ,CDK4I,INK4B,MTS2,P15,TP15,p15INK4b, Gene summary This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq] Location Chromosome: 9   Locus: 9p21 Gene position 22009312 - 22002902  Map Viewer Gene orientation minus Gene size 6411 bp Gene sequence >CDKN2B:complement(21992902..21999312):Length=6411 GGCTCCCCACTCTGCCAGAGCGAGGCGGGGCAGTGAGGACTCCGCGACGCGTCCGCACCC TGCGGCCAGAGCGGCTTTGAGCTCGGCTGCGTCCGCGCTAGGCGCTTTTTCCCAGAAGCA ATCCAGGCGCGCCCGCTGGTTCTTGAGCGCCAGGAAAAGCCCGGAGCTAACGACCGGCCG CTCGGCCACTGCACGGGGCCCCAAGCCGCAGAAGGACGACGGGAGGGTAATGAAGCTGAG CCCAGGTCTCCTAGGAAGGAGAGAGTGCGCCGGAGCAGCGTGGGAAAGAAGGGAAGAGTG TCGTTAAGTTTACGGCCAACGGTGGATTATCCGGGCCGCTGCGCGTCTGGGGGCTGCGGA ATGCGCGAGGAGAACAAGGGCATGCCCAGTGGGGGCGGCAGCGATGAGGGTCTGGCCAGC GCCGCGGCGCGGGGACTAGTGGAGAAGGTGCGACAGCTCCTGGAAGCCGGCGCGGATCCC AACGGAGTCAACCGTTTCGGGAGGCGCGCGATCCAGGTAGCTGGGGCCCCAGGGCCTCGC CGGCAGGGGGCGCGCGAACGCGGGGCGCGGCCTCGGCGGATCGGGGCTGGAACCTAGATC GCCGATGTAGATTTGTACAGGAGTCTCCGTTGGCCGGAGGTGTGCATTCCACGCGTAAAA CAGGCTTTTACCCAGCAAAAATCCTAAAGAGAGACATTGAAAAACCCACTGTTTAAGCTT TTTTTAGTGGTTTTTGTTCTGCCATCTCATGATCAGAGATGCAAGGAATAGACTGAATTG GGGAGAAAAGGAGAAAAGGAAAGCTTATTTAGGGAAGAAGATTATCTTGTCTGTCTGCTT TCAACGATAAAGATAAGTAAAGTATAAGTTACGCATTCTAGATTGGATTTAAGGAATTCT ACAAAATCATAGTACATGGAAAAAATCAATGTAAACTTCTAAGCTACTATATGAAATCTG TTGTATTGTTTTCTCATAGAGGTTAATTGAGAATGAGACGGGATTCCTCAACCACAGTAC TTAGTTCCTTTTATGTTAGCAGTGTCTTATGAGTGATGCATAAGAGAAAAAATATATAGT TCTATAGGTTTCTCATTCTTTAATTATCATACTCAGTGCCCAGATTACAAAAATATTCCT GCAGCAACTGTTAGGTCCTTTTTGAATGGCAAAGGATCTTCATAAATAATGCATCTTTAT CTTCATTGTTAAAATACACTTATTCAATGTTTAAGTACGAATCCTGCTTTAATTAGTACT GATATTTTTTATTTCTTTTACAATCTCGGACAACTCTTTTGTACTTTACCGTTGGCTAGT GGTCATATTCAGTACTCACCTCACTATCACCCTCTAAAACTAAGCTAATATTAAGGGATC TTGTTAATAGTATAGATTTTAAAGAAGTGTTCATTTCTTTTGAATTCTTAGAATAATGGT ATAACAAATGAGGGATTTTTAAAGGAGCAAAAATATTGTAAAGTGCATCTTAAAAACTTA AAATTTTATTAATAATTATAAAAACAAGTTATATATGTAATTCACCATTTTCTGAAATAC TAACAGCAGCTATTTTCCCCTTTTTTTCTATGTAAAATATCCTTACATCACTAGTAGATA TAACTTATCACGGTTTTTAAGAGATGAAATGAACATTTCTAATATTAATGAAACAAGCCA ACAAAACATGAGAAGTATACTGCCTTTCAATTAAATGGTATATTTTAAAGTGCATAAACC CATAACAAATAACTCGATTTTAGACATTTAGTTACCAAAAATTGTCTTATAATTGACTTT AAATATGACAGCAAATGTTTTCATAATGTTCATGTACACAAATGGCTGCTACAGGATTAC TCCTGCAAAACATCATTTTTTCTAAGTTATGCATCATCCTGATTGACTGCTAACATCCAA GCTCTATTTATTTATTTATTTATTTTATTTTTTTTGAGATGAGGCCTCACTCTGTCGGAC AGGCTGGAGTGCAGTGGCACAATCTCAGCTCACTGCAACCTCTTCCAGGATGCAAGCGAT TCTCCTGCCTCAGCCTCCTGAGTTGCTGGGACTACAGGCACGCCCCACCATGCCCAGCTA ATTTTTTATTTTTTGTAGTAGAGACGGGATTTCACCATGTTGGCCAGGCTGGTCTCGAAC TCCTGACCTCAGGTGATCTGCCTGCTATGGCCTCCCAAAGTGCTGGGATTACAGGCATAA GCCACTGGGCCTGGCCCAAGCTCTTTTTATATAGCAAAATATTTACTGTTTAACATTTTT AAATCTTAGCTATTATAAAATCCTGTAGTATACAAATATAGTTAGTTTTATATTACATTA AAAATATTATAGTCTAAATTTAAAATGATGAACTGTTAAGGAAAAATCATTTATTATAAT TTTATAAGATTTTGCATGATTTAATTTACTTTTCCCTTCTAATCTCCAACTTTGGCTCAA ATTATCACACTACAAGCCAGTTATGAGCTCAGACACATGACAAACAAAAGCCTTCCGCAC GGGATTTGCTATGAGAACTAAATAAATTAAAAAAAAAAGAAAGAAAAAAACTTAGTTGTT TATTTTCTCCCCTAAACCATTACTCCCAACTTCTAACAAACAGTAGTTGACTACCTAATA AATATTTGTAGACCTGGATTATGGAGGAGGGGTCAGCAAGGCAAATAATTTAAAACTTTA AAAGCCGAATAAATTTAACTCTGCCCCTAAATCATTTAACAAAATAGATTCCCATGTTCC AATGGAAATCAAGATTTGTTTTTCCATAATGATGATCATCACTTTACCATCAACTTTCTT GTCTCTGCACGTTTAGAGAATAAAATGGCATTTAATTTGTACTGAGTATAACCTGAAGGT GGGGTGGGAAAGTGGATTGCATCAGCAAATGAAGAAACACCAGACATCAGAGACCTGAAC ACCTCTGCACTGGGTGAAAACTTTGCAATTAGGTGTTTCTTTAAATGGCTCCACCTGCCT TGCCCCGGCCGGCATCTCCCATACCTGCCCCCACCCTGGCTCTGACCACTCTGCTCTCTC TGGCAGGTCATGATGATGGGCAGCGCCCGCGTGGCGGAGCTGCTGCTGCTCCACGGCGCG GAGCCCAACTGCGCAGACCCTGCCACTCTCACCCGACCGGTGCATGATGCTGCCCGGGAG GGCTTCCTGGACACGCTGGTGGTGCTGCACCGGGCCGGGGCGCGGCTGGACGTGCGCGAT GCCTGGGGTCGTCTGCCCGTGGACTTGGCCGAGGAGCGGGGCCACCGCGACGTTGCAGGG TACCTGCGCACAGCCACGGGGGACTGACGCCAGGTTCCCCAGCCGCCCACAACGACTTTA TTTTCTTACCCAATTTCCCACCCCCACCCACCTAATTCGATGAAGGCTGCCAACGGGGAG CGGCGGAAAGCCTGTAAGCCTGCAAGCCTGTCTGAGACTCACAGGAAGGAGGAGCCGACC GGGAATAACCTTCCATACATTTTTTTCTTTGTCTTATCTGGCCCTCGACACTCACCATGA AGCGAAACACAGAGAAGCGGATTTCCAGGGATATTTAGGAGTGTGTGACATTCCAGGGGT CGTTTGCTTTTCAGGGTTTTCTGAGGGAAAGTGCATATGAAATCCTTGACTGGACCTGGT GGCTACGAATCTTCCGATGGATGAATCTCCCACTCCAGCGCTGAGTGGGAGAAGGCAGTG ATTAGCACTTGGGTGACGGCAGTCGATGCGTTCACTCCAATGTCTGCTGAGGAGTTATGG TGAACCCACAACTTAGGCCCTAGCGGCAGAAAGGAAAACCTGAAGACTGAGGACAAAGTG GAGGAGGGCCGAGGTGGGCTTCAGTAAGTCCCCGGCGGCGCTTTAGTTTGAGCGCATGGC AAGTCACATGCGTAAACGACACTCTCTGGAAGCCCTGGAGACCCTCGCCCAACTCCACCA GATAGCAGAGGGGTAAGAGAGGATGTGCAAGCGACGACAGATGCTAAAATCCCTGGATCA CGACGCTGCAGAGCACCTTTGCACAGGATGCTGGCCTTTGCTCTTACTACACTGAGGAGA GATTCCCGCGGGTTCCGCAGGCAGACTACACAGGATGAGGTGGTGGAGTGGAGTGAGAGC AATTGTAACGGTTAACTGTAACGTTTTCTTTCACACACACACACACACACACACACACAC ATGCTAGGATGCGGAAATCCCCTTATGACTTGCTACTTTTTGATTTTGTGATATTTTGTA CTTTTTAGTTGTTCAGCAACTGTCTTATTTAATGGGGAGATTTTAAGTAACATAACTAGT GGCTCTCAGTTAAAATGTGAGGAAGAACTACAGCTCTTAAATGTAGCAATGGCACTGTTG CAAACTCAGTGCAAACGCCTAGATTGCTTTCTTCTTAACCTATTTATTTCTTTGTTAAAT TTTTCTGATTGTTTCCTTTATAGAGTGTCTCAGGGTGCAGAGGTCAGACTAAGAAATATT CCAAATGTCTTTTAGAAGATAGATGCACTTATGCAGTAAATTATCTTGGGATAGTTCCCA AAAGATTGCTGAAAAAGTAGATTGAGTATAAAAACTTGAAAATATATGATGGCTCGTGGG ATGTCCTACTATCACTGAACAAACTAAAGGTGCACTGCTTTGGGATTTAATTTCCAGGGT TGCTTGATCATTATATCATTGGAACAACTGATACTTCACTACTTTAATAAAGAATTAACA GAGATTGAACTCCAAGAGGTGGGTAATTTGGTTTAAAAATACATGTTCATGGGTTTACCA CTAACTCCTGAGAAATGTTAAAGGTTCACAGGGGTTCCCTTCTCTCAATGTTTGTAATAA TTGCTCATAAGCAATACCAGCAATTCATAAAAACTGCTTACTTATGCCATAGAAAATTAA ACACAAAGTGTATACATGTATTATGCTTCTAAATGCTCATTCTACCAGATACACATTTAA AAGAGAAAAAAGGAACAGAAACAAGTCATTTGAGAGTGGAGACTTATAAGAAGGAGTACA TTTGAGTTGAATACACAAATCTTTACTTCTCTACCAATTCCTATTCCCAAAATGAACATA TTACTGGGGAAAGTTAGTTGAGAATCAGAGCATATGTTATTGGGGAAAGGATATGTTTAT TGACACATAATCTGTACCAGGTATGCATTAAAATATATTTGTTAATTTAATATTTAAACC TGAGAGATAGGTATTGTTTCCCAGATGAGGACAATGAGGCAAAGAAATATCAAGTAACTT GCCAAAGGTTACAAGATATTCATTCCATGGATGCACAAAGAAGTGCATCTAGTTCCACAG CTGATTATGGTTGTCTTGCTTTTCTTCCCATTGCACCAGCTTGTCCTCCAAAATCATGAA TGATACACATGAAGATAACTTTTTTTAAAAAAAAGCAGAAATACACAATGATCTCCCTTG TAAGCTCCTAAGGTGGCTTTTCTTTCTCTAACTTCTAGTAAATATAAACGGTTTGTTTGA AAACTATTTTAAAATGTCAACAATATGGAGAATAACCCCCCCCAACACACCTATAAAAAC CCAAATTTTTGGAACAAAGATAATGGAACCTCCATTTTCAAACTGAAGCACAGGGACAGA AAATATATTTCTAGTTATCACTTAAGCACTCAATCATTAGAGGCTACAAGAATAATATTT TTAAAGTTACAGTATTTTACAATTATTAGAAAACATTCTATATAAAAGAAGTCAGTTGAT ACTTTAAAATCTCCCATTTGGTTTATAAAATCCCTTAATTTGACCTCTATATCTTAAATT CCAAGATGTTTAAATTTGCTAGTTGCATTATACTGGGTCATGAAAAATTATCCCTTGAAA TAGATATGAAACATGTTACTTCATTTCTGGTTTAAATAACTTGTGGAATCTTTCCTAATG ACAACCTGATATTAAGGGAAACTAAAGAAAATGTTATTGTGGATCCCACAGTACTATATT ACACTGTTTTTTTTGTTTGTTTTGTTAGTTTTTTTTATTTAAAGCAAACCTCAAACATTA TTGGGTATCAATTACCACCTGGTTGTATTGAAATAGTAACTTATCAATGCCATGTAAAAA TTAATTCCATTTTCGAAGCCACCTGGCAGACAGGTTTAGCTGTTTCATCAGCAGCCTAAT ATATACTGTTAAATTTGTTAAGGATTTCACTTTGAAGGATACATGCAAAACATATAGTTA CTATTTTCATGAGTCCTGCTTCTAGCTCCATTGTGGAATACAGAAAATTAAATATACCTG TTAAGTTCGTATCTAAACCTAAGACATTACCAAGGTTTGTACAAATTCTACTACCTGACA TTTATTCCAAGAAGATCTGGAAAGTTAAATAAATTTATAAATTTAATAACA OMIM ID 600431