Entrez gene ID | | 10380 |
Official gene symbol | | BPNT1 |
Full name | | 3'(2'), 5'-bisphosphate nucleotidase 1 |
Aliases | | ,PIP, |
Gene summary | | BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity. [provided by RefSeq] |
Location | | Chromosome: 1 Locus: 1q41 |
Gene position | | 220263191 - 220230824 Map Viewer |
Gene orientation | | minus |
Gene size | | 32368 bp |
Gene sequence |
| |
OMIM ID | | 604053 |
|