Entrez gene ID | | 10451 |
Official gene symbol | | VAV3 |
Full name | | vav 3 guanine nucleotide exchange factor |
Aliases | | ,FLJ40431, |
Gene summary | | This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq] |
Location | | Chromosome: 1 Locus: 1p13.3 |
Gene position | | 108507545 - 108113782 Map Viewer |
Gene orientation | | minus |
Gene size | | 393764 bp |
Gene sequence |
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OMIM ID | | 605541 |
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