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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for NXF1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID10482
Official gene symbolNXF1
Full namenuclear RNA export factor 1
Aliases,DKFZp667O0311,MEX67,TAP,
Gene summaryThis gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
LocationChromosome: 11   Locus: 11q12-q13
Gene position62572964 - 62559598  Map Viewer
Gene orientationminus
Gene size13367 bp
Gene sequence
OMIM ID602647