Entrez gene ID | | 10540 |
Official gene symbol | | DCTN2 |
Full name | | dynactin 2 (p50) |
Aliases | | ,DCTN50,DYNAMITIN,RBP50, |
Gene summary | | This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. [provided by RefSeq] |
Location | | Chromosome: 12 Locus: 12q13.2-q13.3 |
Gene position | | 57940978 - 57924094 Map Viewer |
Gene orientation | | minus |
Gene size | | 16885 bp |
Gene sequence |
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OMIM ID | | 607376 |
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