| Entrez gene ID | | 1059 |
|
| Official gene symbol | | CENPB |
|
| Full name | | centromere protein B, 80kDa |
|
| Aliases | | ,-, |
|
| Gene summary | | This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies. [provided by RefSeq] |
|
| Location | | Chromosome: 20 Locus: 20p13 |
|
| Gene position | | 3767337 - 3764498 Map Viewer |
|
| Gene orientation | | minus |
|
| Gene size | | 2840 bp |
|
| Gene sequence |
| |
|
